Immunization to a syngeneic sarcoma by a monoclonal auto-anti-idiotypic antibody.

abstract：:The hydroxyl radical (OH) is a key oxidant involved in the removal of air pollutants and greenhouse gases from the atmosphere. The ratio of Northern Hemispheric to Southern Hemispheric (NH/SH) OH concentration is important for our understanding of emission estimates of atmospheric species such as nitrogen oxides and m...

journal_title：Nature

authors： Patra PK,Krol MC,Montzka SA,Arnold T,Atlas EL,Lintner BR,Stephens BB,Xiang B,Elkins JW,Fraser PJ,Ghosh A,Hintsa EJ,Hurst DF,Ishijima K,Krummel PB,Miller BR,Miyazaki K,Moore FL,Mühle J,O'Doherty S,Prinn RG,Steele

更新日期：2014-09-11 00:00:00

abstract：:Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that ...

journal_title：Nature

authors： Price MP,Lewin GR,McIlwrath SL,Cheng C,Xie J,Heppenstall PA,Stucky CL,Mannsfeldt AG,Brennan TJ,Drummond HA,Qiao J,Benson CJ,Tarr DE,Hrstka RF,Yang B,Williamson RA,Welsh MJ

更新日期：2000-10-26 00:00:00

abstract：:During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression1, but the gene regulatory network that co...

journal_title：Nature

authors： Hamazaki N,Kyogoku H,Araki H,Miura F,Horikawa C,Hamada N,Shimamoto S,Hikabe O,Nakashima K,Kitajima TS,Ito T,Leitch HG,Hayashi K

更新日期：2021-01-01 00:00:00

abstract：:DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (P...

journal_title：Nature

authors： Calo E,Flynn RA,Martin L,Spitale RC,Chang HY,Wysocka J

更新日期：2015-02-12 00:00:00

abstract：:Ordinarily, photons do not interact with one another. However, atoms can be used to mediate photonic interactions1,2, raising the prospect of forming synthetic materials3 and quantum information systems4-7 from photons. One promising approach combines highly excited Rydberg atoms8-12 with the enhanced light-matter cou...

journal_title：Nature

authors： Clark LW,Jia N,Schine N,Baum C,Georgakopoulos A,Simon J

更新日期：2019-07-01 00:00:00

abstract：:The Kyoto Protocol permits countries to meet part of their emission reduction obligations by cutting back on gases other than CO2 (ref. 1). This approach requires a definition of trade-offs among the radiatively active gases. The Intergovernmental Panel on Climate Change has suggested global warming potentials for thi...

journal_title：Nature

authors： Manne AS,Richels RG

更新日期：2001-04-05 00:00:00

abstract：:Macroscopic mechanical objects and electromagnetic degrees of freedom can couple to each other through radiation pressure. Optomechanical systems in which this coupling is sufficiently strong are predicted to show quantum effects and are a topic of considerable interest. Devices in this regime would offer new types of...

journal_title：Nature

authors： Thompson JD,Zwickl BM,Jayich AM,Marquardt F,Girvin SM,Harris JG

更新日期：2008-03-06 00:00:00

abstract：:Scientific fraud, much in the news recently, is not a new phenomenon. What follows is a personal account of a particular case. ...

journal_title：Nature

authors： Rossiter EJ

更新日期：1992-06-11 00:00:00

abstract：:Haemoglobin is the prototype of an allosteric protein in which cooperative behaviour depends on interaction between unlike subunits. Here we present haematological and biochemical evidence that electrostatic interactions are an important determinant of haemoglobin assembly. Individuals heterozygous for positively char...

journal_title：Nature

authors： Bunn HF,McDonald MJ

更新日期：1983-12-01 00:00:00

abstract：:Mistranslation arising from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences. Throughout evolution, two editing checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bacteria and mice,...

journal_title：Nature

authors： Guo M,Chong YE,Shapiro R,Beebe K,Yang XL,Schimmel P

更新日期：2009-12-10 00:00:00

abstract：:Thomas et al. argue, contrary to Sala et al. that climate change poses an equal or greater threat to global biodiversity than land-use change. We contest this claim, however, on the grounds that Thomas et al. incorrectly apply species-area relationships. ...

journal_title：Nature

authors： Buckley LB,Roughgarden J

更新日期：2004-07-01 00:00:00

abstract：:A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-depende...

journal_title：Nature

authors： Slot JW,Moxley R,Geuze HJ,James DE

更新日期：1990-07-26 00:00:00

abstract：:Deoxygenated sickle haemoglobin polymerizes into long 210-A diameter fibres that distort and decrease the deformability of red blood cells, and cause sickle cell disease. The fibres consist of seven intertwined double strands. They can form birefringent nematic liquid crystals (tactoids) and spherulites. Rheologically...

journal_title：Nature

authors： Samuel RE,Salmon ED,Briehl RW

更新日期：1990-06-28 00:00:00

abstract：:Global efforts to mitigate climate change are guided by projections of future temperatures. But the eventual equilibrium global mean temperature associated with a given stabilization level of atmospheric greenhouse gas concentrations remains uncertain, complicating the setting of stabilization targets to avoid potenti...

journal_title：Nature

authors： Allen MR,Frame DJ,Huntingford C,Jones CD,Lowe JA,Meinshausen M,Meinshausen N

更新日期：2009-04-30 00:00:00

abstract：:Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...

journal_title：Nature

authors： Joshi PK,Esko T,Mattsson H,Eklund N,Gandin I,Nutile T,Jackson AU,Schurmann C,Smith AV,Zhang W,Okada Y,Stančáková A,Faul JD,Zhao W,Bartz TM,Concas MP,Franceschini N,Enroth S,Vitart V,Trompet S,Guo X,Chasman DI,

更新日期：2015-07-23 00:00:00

abstract：:Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cells. Once activated, they proliferate vigorously, generating effector cells that can migrate to B-cell areas or to inflamed tissues. A fraction of primed T lymphocytes persists as circulating memory ce...

journal_title：Nature

authors： Sallusto F,Lenig D,Förster R,Lipp M,Lanzavecchia A

更新日期：1999-10-14 00:00:00

abstract：: ...

journal_title：Nature

authors： Smallman M

更新日期：2019-03-01 00:00:00

abstract：:Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of GHS-R strongly suggests that an endogenous ligand for the receptor does exist and...

journal_title：Nature

authors： Kojima M,Hosoda H,Date Y,Nakazato M,Matsuo H,Kangawa K

更新日期：1999-12-09 00:00:00

abstract：:Mice express a collection of superantigens, which bind to class II major histocompatibility proteins and interact with T cells bearing particular V beta chains as part of their alpha beta receptors. These superantigens have been suggested to be encoded by exogenous or endogenous mouse mammary tumour viruses. One such ...

journal_title：Nature

authors： Choi Y,Kappler JW,Marrack P

更新日期：1991-03-21 00:00:00

abstract：:The Haldane model on a honeycomb lattice is a paradigmatic example of a Hamiltonian featuring topologically distinct phases of matter. It describes a mechanism through which a quantum Hall effect can appear as an intrinsic property of a band structure, rather than being caused by an external magnetic field. Although p...

journal_title：Nature

authors： Jotzu G,Messer M,Desbuquois R,Lebrat M,Uehlinger T,Greif D,Esslinger T

更新日期：2014-11-13 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:The recent decades-long decline in East African rainfall suggests that multidecadal variability is an important component of the climate of this vulnerable region. Prior work based on analysing the instrumental record implicates both Indian and Pacific ocean sea surface temperatures (SSTs) as possible drivers of East ...

journal_title：Nature

authors： Tierney JE,Smerdon JE,Anchukaitis KJ,Seager R

更新日期：2013-01-17 00:00:00

abstract：:Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its mai...

journal_title：Nature

authors： Scita G,Di Fiore PP

更新日期：2010-01-28 00:00:00

abstract：:Recurring outbursts associated with matter flowing onto compact stellar remnants (such as black holes, neutron stars and white dwarfs) in close binary systems provide a way of constraining the poorly understood accretion process. The light curves of these outbursts are shaped by the efficiency of angular-momentum (and...

journal_title：Nature

authors： Tetarenko BE,Lasota JP,Heinke CO,Dubus G,Sivakoff GR

更新日期：2018-02-01 00:00:00

abstract：:The macronutrient phosphorus is thought to limit primary productivity in the oceans on geological timescales. Although there has been a sustained effort to reconstruct the dynamics of the phosphorus cycle over the past 3.5 billion years, it remains uncertain whether phosphorus limitation persisted throughout Earth's h...

journal_title：Nature

authors： Reinhard CT,Planavsky NJ,Gill BC,Ozaki K,Robbins LJ,Lyons TW,Fischer WW,Wang C,Cole DB,Konhauser KO

更新日期：2017-01-19 00:00:00

abstract：:Long-term depletion of the stratospheric ozone layer contributes to an increase in terrestrial solar ultraviolet-B radiation. This has deleterious effects on living organisms, such as DNA damage. When exposed to elevated ultraviolet-B radiation (UV-B; 280-315 nm), plants display a wide variety of physiological and mor...

journal_title：Nature

authors： Ries G,Heller W,Puchta H,Sandermann H,Seidlitz HK,Hohn B

更新日期：2000-07-06 00:00:00

abstract：:Most stars become white dwarfs after they have exhausted their nuclear fuel (the Sun will be one such). Between one-quarter and one-half of white dwarfs have elements heavier than helium in their atmospheres, even though these elements ought to sink rapidly into the stellar interiors (unless they are occasionally repl...

journal_title：Nature

authors： Vanderburg A,Johnson JA,Rappaport S,Bieryla A,Irwin J,Lewis JA,Kipping D,Brown WR,Dufour P,Ciardi DR,Angus R,Schaefer L,Latham DW,Charbonneau D,Beichman C,Eastman J,McCrady N,Wittenmyer RA,Wright JT

更新日期：2015-10-22 00:00:00

abstract：:A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...

journal_title：Nature

authors： Dodds AW,Ren XD,Willis AC,Law SK

更新日期：1996-01-11 00:00:00

abstract：:Planetary aurorae are formed by energetic charged particles streaming along the planet's magnetic field lines into the upper atmosphere from the surrounding space environment. Earth's main auroral oval is formed through interactions with the solar wind, whereas that at Jupiter is formed through interactions with plasm...

journal_title：Nature

authors： Stallard T,Miller S,Melin H,Lystrup M,Cowley SW,Bunce EJ,Achilleos N,Dougherty M

更新日期：2008-06-19 00:00:00

abstract：:The success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatin-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks, which unwind and bend the duplex to facilitate the binding of proteins that contain one or more high-mobility group (HMG) domains. ...

journal_title：Nature

authors： Takahara PM,Rosenzweig AC,Frederick CA,Lippard SJ

更新日期：1995-10-19 00:00:00