The endocytic matrix.

abstract：:Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide v...

journal_title：Nature

authors： Schliwa M,Woehlke G

更新日期：2003-04-17 00:00:00

abstract：:Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...

journal_title：Nature

authors： Trainor CD,Evans T,Felsenfeld G,Boguski MS

更新日期：1990-01-04 00:00:00

abstract：:Bacterial adhesion pili are designed to bind specifically and maintain attachment of bacteria to target cells. Uropathogenic P-pili are sufficiently mechanically resilient to resist the cleansing action of urine flow that removes most other bacteria. P-pili are 68 A in diameter and approximately 1 micron long, and are...

journal_title：Nature

authors： Bullitt E,Makowski L

更新日期：1995-01-12 00:00:00

abstract：:Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...

journal_title：Nature

authors： Endo M,Muramatsu H,Hayashi T,Kim YA,Terrones M,Dresselhaus MS

更新日期：2005-02-03 00:00:00

abstract：:It has long been thought that mature oligodendrocytes in the adult mammalian central nervous system (CNS) are post-mitotic and are unable to proliferate in response to injury. The implications of this have been profound, because it has been suggested that this failure of oligodendrocytes to undergo mitosis is perhaps ...

journal_title：Nature

authors： Ludwin SK

更新日期：1984-03-15 00:00:00

abstract：:Quantum electrodynamics (resulting from the merger of quantum mechanics and relativity theory) has provided a clear understanding of phenomena ranging from particle physics to cosmology and from astrophysics to quantum chemistry. The ideas underlying quantum electrodynamics also influence the theory of condensed matte...

journal_title：Nature

authors： Novoselov KS,Geim AK,Morozov SV,Jiang D,Katsnelson MI,Grigorieva IV,Dubonos SV,Firsov AA

更新日期：2005-11-10 00:00:00

abstract：:Germinal centres are specialized structures wherein B lymphocytes undergo clonal expansion, class switch recombination, antibody gene diversification and affinity maturation. Three to four antigen-specific B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-centre centroblas...

journal_title：Nature

authors： Schwickert TA,Lindquist RL,Shakhar G,Livshits G,Skokos D,Kosco-Vilbois MH,Dustin ML,Nussenzweig MC

更新日期：2007-03-01 00:00:00

abstract：:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...

journal_title：Nature

authors： Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

更新日期：2008-04-03 00:00:00

abstract：:The protein TFIIB is a general transcription initiation factor that interacts with a promoter complex (D.DNA) containing the TATA-binding subunit (TFIID tau, or TBP) of TFIID to facilitate subsequent interaction with RNA polymerase II (ref. 2) through the associated TFIIF (ref. 3). The potential bridging function of T...

journal_title：Nature

authors： Hisatake K,Roeder RG,Horikoshi M

更新日期：1993-06-24 00:00:00

abstract：:The conventional treatment of dental caries involves mechanical removal of the affected part and filling of the hole with a resin or metal alloy. But this method is not ideal for tiny early lesions because a disproportionate amount of healthy tooth must be removed to make the alloy or resin stick. Here we describe a d...

journal_title：Nature

authors： Yamagishi K,Onuma K,Suzuki T,Okada F,Tagami J,Otsuki M,Senawangse P

更新日期：2005-02-24 00:00:00

abstract：:The Redfield ratio of 106 carbon:16 nitrogen:1 phosphorus in marine phytoplankton is one of the foundations of ocean biogeochemistry, with applications in algal physiology, palaeoclimatology and global climate change. However, this ratio varies substantially in response to changes in algal nutrient status and taxonomi...

journal_title：Nature

authors： Sañudo-Wilhelmy SA,Tovar-Sanchez A,Fu FX,Capone DG,Carpenter EJ,Hutchins DA

更新日期：2004-12-16 00:00:00

abstract：:The fruit, which mediates the maturation and dispersal of seeds, is a complex structure unique to flowering plants. Seed dispersal in plants such as Arabidopsis occurs by a process called fruit dehiscence, or pod shatter. Few studies have focused on identifying genes that regulate this process, in spite of the agronom...

journal_title：Nature

authors： Liljegren SJ,Ditta GS,Eshed Y,Savidge B,Bowman JL,Yanofsky MF

更新日期：2000-04-13 00:00:00

abstract：:Methane-oxidizing bacteria (methanotrophs) require large quantities of copper for the membrane-bound (particulate) methane monooxygenase. Certain methanotrophs are also able to switch to using the iron-containing soluble methane monooxygenase to catalyse methane oxidation, with this switchover regulated by copper. Met...

journal_title：Nature

authors： Vita N,Platsaki S,Baslé A,Allen SJ,Paterson NG,Crombie AT,Murrell JC,Waldron KJ,Dennison C

更新日期：2015-09-03 00:00:00

abstract：:Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smoking. One likely target for these effects is the hippocampus, a centr...

journal_title：Nature

authors： Gray R,Rajan AS,Radcliffe KA,Yakehiro M,Dani JA

更新日期：1996-10-24 00:00:00

abstract：:Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP...

journal_title：Nature

authors： Ray Chaudhuri A,Callen E,Ding X,Gogola E,Duarte AA,Lee JE,Wong N,Lafarga V,Calvo JA,Panzarino NJ,John S,Day A,Crespo AV,Shen B,Starnes LM,de Ruiter JR,Daniel JA,Konstantinopoulos PA,Cortez D,Cantor SB,Fernandez-Ca

更新日期：2016-07-21 00:00:00

abstract：:The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent development. Concomitantly, epiblast cells tran...

journal_title：Nature

authors： Shahbazi MN,Scialdone A,Skorupska N,Weberling A,Recher G,Zhu M,Jedrusik A,Devito LG,Noli L,Macaulay IC,Buecker C,Khalaf Y,Ilic D,Voet T,Marioni JC,Zernicka-Goetz M

更新日期：2017-12-14 00:00:00

abstract：:Little is known about virus-host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the alphavirus genus (family Togaviridae), results in lytic infection in most vertebrate cell lines, but persistent productive...

journal_title：Nature

authors： Levine B,Huang Q,Isaacs JT,Reed JC,Griffin DE,Hardwick JM

更新日期：1993-02-25 00:00:00

abstract：:alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...

journal_title：Nature

authors： Freeman JA

更新日期：1977-09-15 00:00:00

abstract：:The angle between the spin of a star and the orbital planes of its planets traces the history of the planetary system. Exoplanets orbiting close to cool stars are expected to be on circular, aligned orbits because of strong tidal interactions with the stellar convective envelope. Spin-orbit alignment can be measured w...

journal_title：Nature

authors： Bourrier V,Lovis C,Beust H,Ehrenreich D,Henry GW,Astudillo-Defru N,Allart R,Bonfils X,Ségransan D,Delfosse X,Cegla HM,Wyttenbach A,Heng K,Lavie B,Pepe F

更新日期：2018-01-25 00:00:00

abstract：:The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...

journal_title：Nature

authors： Boriack-Sjodin PA,Margarit SM,Bar-Sagi D,Kuriyan J

更新日期：1998-07-23 00:00:00

abstract：:Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...

journal_title：Nature

authors： Sugimoto Y,Pou P,Abe M,Jelinek P,Pérez R,Morita S,Custance O

更新日期：2007-03-01 00:00:00

abstract：:Originally described by Lugaresi et al. in 1986 (ref. 1), fatal familial insomnia (FFI) is a rare inherited neurological disease characterized by the subacute progression of intractable insomnia and other autonomic abnormalities, cerebellar and pyramidal signs, myoclonus and dementia; neuropathologically, the major fe...

journal_title：Nature

authors： Tateishi J,Brown P,Kitamoto T,Hoque ZM,Roos R,Wollman R,Cervenáková L,Gajdusek DC

更新日期：1995-08-03 00:00:00

abstract：:Nucleosomes cover most of the genome and are thought to be displaced by transcription factors in regions that direct gene expression. However, the modes of interaction between transcription factors and nucleosomal DNA remain largely unknown. Here we systematically explore interactions between the nucleosome and 220 tr...

journal_title：Nature

authors： Zhu F,Farnung L,Kaasinen E,Sahu B,Yin Y,Wei B,Dodonova SO,Nitta KR,Morgunova E,Taipale M,Cramer P,Taipale J

更新日期：2018-10-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Tall AR,Jelic S

更新日期：2019-02-01 00:00:00

abstract：:Sheep learn to recognize the odours of their lambs within two hours of giving birth, and this learning involves synaptic changes within the olfactory bulb. Specifically, mitral cells become increasingly responsive to the learned odour, which stimulates release of both glutamate and GABA (gamma-aminobutyric acid) neuro...

journal_title：Nature

authors： Kendrick KM,Guevara-Guzman R,Zorrilla J,Hinton MR,Broad KD,Mimmack M,Ohkura S

更新日期：1997-08-14 00:00:00

abstract：:We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness...

journal_title：Nature

authors： Le Chatelier E,Nielsen T,Qin J,Prifti E,Hildebrand F,Falony G,Almeida M,Arumugam M,Batto JM,Kennedy S,Leonard P,Li J,Burgdorf K,Grarup N,Jørgensen T,Brandslund I,Nielsen HB,Juncker AS,Bertalan M,Levenez F,Pons N,

更新日期：2013-08-29 00:00:00

abstract：:Piezoelectric materials, which convert mechanical to electrical energy (and vice versa), are crucial in medical imaging, telecommunication and ultrasonic devices. A new generation of single-crystal materials, such as Pb(Zn1/3Nb2/3)O3-PbTiO3 (PZN-PT) and Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT), exhibit a piezoelectric effect ...

journal_title：Nature

authors： Fu H,Cohen RE

更新日期：2000-01-20 00:00:00

abstract：:Hydrodynamic flow in classical and quantum fluids can be either laminar or turbulent. Vorticity in turbulent flow is often modelled with vortex filaments. While this represents an idealization in classical fluids, vortices are topologically stable quantized objects in superfluids. Superfluid turbulence is therefore th...

journal_title：Nature

authors： Finne AP,Araki T,Blaauwgeers R,Eltsov VB,Kopnin NB,Krusius M,Skrbek L,Tsubota M,Volovik GE

更新日期：2003-08-28 00:00:00

abstract：:Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...

journal_title：Nature

authors： Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba

更新日期：2009-08-13 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN-1) is a predisposition to hyperplasia of the parathyroid glands, and to hyperplasia or tumours of the anterior pituitary and the endocrine pancreas, and is inherited as an autosomal dominant trait. Here we map the MEN-1 locus to chromosome 11 by family studies, and demonstrate ...

journal_title：Nature

authors： Larsson C,Skogseid B,Oberg K,Nakamura Y,Nordenskjöld M

更新日期：1988-03-03 00:00:00