The interaction landscape between transcription factors and the nucleosome.

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...

journal_title：Nature

authors： Li W,Shuai L,Wan H,Dong M,Wang M,Sang L,Feng C,Luo GZ,Li T,Li X,Wang L,Zheng QY,Sheng C,Wu HJ,Liu Z,Liu L,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2012-10-18 00:00:00

abstract：:The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an i...

journal_title：Nature

authors： Khaminets A,Heinrich T,Mari M,Grumati P,Huebner AK,Akutsu M,Liebmann L,Stolz A,Nietzsche S,Koch N,Mauthe M,Katona I,Qualmann B,Weis J,Reggiori F,Kurth I,Hübner CA,Dikic I

更新日期：2015-06-18 00:00:00

abstract：:Change history: In this Letter, the received date should be 20 December 2017, instead of 27 April 2018. This has been corrected online. ...

journal_title：Nature

authors： Humphreys PC,Kalb N,Morits JPJ,Schouten RN,Vermeulen RFL,Twitchen DJ,Markham M,Hanson R

更新日期：2018-10-01 00:00:00

abstract：:Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...

journal_title：Nature

authors： King IF,Yandava CN,Mabb AM,Hsiao JS,Huang HS,Pearson BL,Calabrese JM,Starmer J,Parker JS,Magnuson T,Chamberlain SJ,Philpot BD,Zylka MJ

更新日期：2013-09-05 00:00:00

abstract：:Where continental plates break apart, slip along multiple normal faults provides the required space for the Earth's crust to thin and subside. After initial rifting, however, the displacement on normal faults observed at the sea floor seems not to match the inferred extension. Here we show that crustal thinning can be...

journal_title：Nature

authors： Lavier LL,Manatschal G

更新日期：2006-03-16 00:00:00

abstract：:The cyanobacterium Prochlorococcus is the dominant oxygenic phototroph in the tropical and subtropical regions of the world's oceans. It can grow at a range of depths over which light intensities can vary by up to 4 orders of magnitude. This broad depth distribution has been hypothesized to stem from the coexistence o...

journal_title：Nature

authors： Moore LR,Rocap G,Chisholm SW

更新日期：1998-06-04 00:00:00

abstract：:Nearly all protocols requiring shared quantum information--such as quantum teleportation or key distribution--rely on entanglement between distant parties. However, entanglement is difficult to characterize experimentally. All existing techniques for doing so, including entanglement witnesses or Bell inequalities, dis...

journal_title：Nature

authors： Walborn SP,Souto Ribeiro PH,Davidovich L,Mintert F,Buchleitner A

更新日期：2006-04-20 00:00:00

abstract：:Mechanotransduction has an important role in physiology. Biological processes including sensing touch and sound waves require as-yet-unidentified cation channels that detect pressure. Mouse Piezo1 (MmPiezo1) and MmPiezo2 (also called Fam38a and Fam38b, respectively) induce mechanically activated cationic currents in c...

journal_title：Nature

authors： Coste B,Xiao B,Santos JS,Syeda R,Grandl J,Spencer KS,Kim SE,Schmidt M,Mathur J,Dubin AE,Montal M,Patapoutian A

更新日期：2012-02-19 00:00:00

abstract：:Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...

journal_title：Nature

authors： Sicardy B,Widemann T,Lellouch E,Veillet C,Cuillandre JC,Colas F,Roques F,Beisker W,Kretlow M,Lagrange AM,Gendron E,Lacombe F,Lecacheux J,Birnbaum C,Fienga A,Leyrat C,Maury A,Raynaud E,Renner S,Schultheis M,Brooks

更新日期：2003-07-10 00:00:00

abstract：:The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...

journal_title：Nature

authors： Ortega P,Lehner F,Swingedouw D,Masson-Delmotte V,Raible CC,Casado M,Yiou P

更新日期：2015-07-02 00:00:00

abstract：:A large impact by a comet or meteorite releases an enormous amount of energy, which evaporates, melts and fractures the surrounding rocks. Distinctive features of such impacts are 'shatter cones', deformed rocks characterized by hierarchical striated features. Although such features have been used for decades as unequ...

journal_title：Nature

authors： Sagy A,Reches Z,Fineberg J

更新日期：2002-07-18 00:00:00

abstract：:The guinea-pig (Cavia porcellus), traditionally classified as a New World hystricomorph rodent, often shows anomalous morphological and molecular features in comparison with other eutherian mammals. For example, its insulin differs from that of other mammals in anabolic and growth-promoting activities and in its capab...

journal_title：Nature

authors： Graur D,Hide WA,Li WH

更新日期：1991-06-20 00:00:00

abstract：:Vertebrate and invertebrate digestive systems show extensive similarities in their development, cellular makeup and genetic control. The Drosophila midgut is typical: enterocytes make up the majority of the intestinal epithelial monolayer, but are interspersed with hormone-producing enteroendocrine cells. Human (and m...

journal_title：Nature

authors： Ohlstein B,Spradling A

更新日期：2006-01-26 00:00:00

abstract：:'Hot Jupiter' extrasolar planets are expected to be tidally locked because they are close (<0.05 astronomical units, where 1 au is the average Sun-Earth distance) to their parent stars, resulting in permanent daysides and nightsides. By observing systems where the planet and star periodically eclipse each other, sever...

journal_title：Nature

authors： Knutson HA,Charbonneau D,Allen LE,Fortney JJ,Agol E,Cowan NB,Showman AP,Cooper CS,Megeath ST

更新日期：2007-05-10 00:00:00

abstract：:The recent decades-long decline in East African rainfall suggests that multidecadal variability is an important component of the climate of this vulnerable region. Prior work based on analysing the instrumental record implicates both Indian and Pacific ocean sea surface temperatures (SSTs) as possible drivers of East ...

journal_title：Nature

authors： Tierney JE,Smerdon JE,Anchukaitis KJ,Seager R

更新日期：2013-01-17 00:00:00

abstract：:Apoptosis in the immune system is a fundamental process regulating lymphocyte maturation, receptor repertoire selection and homeostasis. Thus, death by apoptosis is as essential for the function of lymphocytes as growth and differentiation. This article focuses on death receptor-associated apoptosis and the role of CD...

journal_title：Nature

authors： Krammer PH

更新日期：2000-10-12 00:00:00

abstract：:A statute banning nuclear weapons research in Cambridge, Massachusetts, is scheduled for a referendum vote in November 1983. If passed, the act would require the city to fine or imprison violators after the ban takes effect in October 1985, and could have an impact on work done at Harvard University and the Massachus...

journal_title：Nature

authors： David P

更新日期：1983-09-15 00:00:00

abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...

journal_title：Nature

authors： Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ

更新日期：2020-03-01 00:00:00

abstract：:Water striders Gerridae are insects of characteristic length 1 cm and weight 10 dynes that reside on the surface of ponds, rivers, and the open ocean. Their weight is supported by the surface tension force generated by curvature of the free surface, and they propel themselves by driving their central pair of hydrophob...

journal_title：Nature

authors： Hu DL,Chan B,Bush JW

更新日期：2003-08-07 00:00:00

abstract：:Sensory experiences exert a powerful influence on the function and future performance of neuronal circuits in the mammalian neocortex. Restructuring of synaptic connections is believed to be one mechanism by which cortical circuits store information about the sensory world. Excitatory synaptic structures, such as dend...

journal_title：Nature

authors： Hofer SB,Mrsic-Flogel TD,Bonhoeffer T,Hübener M

更新日期：2009-01-15 00:00:00

abstract：:Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...

journal_title：Nature

authors： Cooper DM,Mons N,Karpen JW

更新日期：1995-03-30 00:00:00

abstract：:Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease. Numerous studies have dem...

journal_title：Nature

authors： Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M

更新日期：2014-02-27 00:00:00

abstract：:Pinocytosis and membrane ruffling are among the earliest and most dramatic cellular responses to stimulation by growth factors or other mitogens. The small Ras-related G proteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to stimulate pinocytosis when microinjected into Xe...

journal_title：Nature

authors： Lamaze C,Chuang TH,Terlecky LJ,Bokoch GM,Schmid SL

更新日期：1996-07-11 00:00:00

abstract：:Derivatives of the yeast GCN4 transcription factor containing acidic regions of 35 to 40 amino acids fused directly to the DNA-binding domain are fully functional in vivo. High resolution deletion analysis and proteolytic mapping suggest that the activation region is a repeated structure composed of small units acting...

journal_title：Nature

authors： Hope IA,Mahadevan S,Struhl K

更新日期：1988-06-16 00:00:00

abstract：:Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...

journal_title：Nature

authors： Mróz P,Udalski A,Skowron J,Poleski R,Kozłowski S,Szymański MK,Soszyński I,Wyrzykowski Ł,Pietrukowicz P,Ulaczyk K,Skowron D,Pawlak M

更新日期：2017-08-10 00:00:00

abstract：:The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism conv...

journal_title：Nature

authors： Windass JD,Worsey MJ,Pioli EM,Pioli D,Barth PT,Atherton KT,Dart EC,Byrom D,Powell K,Senior PJ

更新日期：1980-10-02 00:00:00

abstract：:Volatile anaesthetics have historically been considered to act in a nonspecific manner on the central nervous system. More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of...

journal_title：Nature

authors： Mihic SJ,Ye Q,Wick MJ,Koltchine VV,Krasowski MD,Finn SE,Mascia MP,Valenzuela CF,Hanson KK,Greenblatt EP,Harris RA,Harrison NL

更新日期：1997-09-25 00:00:00

abstract：:Graphene oxide membranes-partially oxidized, stacked sheets of graphene-can provide ultrathin, high-flux and energy-efficient membranes for precise ionic and molecular sieving in aqueous solution. These materials have shown potential in a variety of applications, including water desalination and purification, gas and ...

journal_title：Nature

authors： Chen L,Shi G,Shen J,Peng B,Zhang B,Wang Y,Bian F,Wang J,Li D,Qian Z,Xu G,Liu G,Zeng J,Zhang L,Yang Y,Zhou G,Wu M,Jin W,Li J,Fang H

更新日期：2017-10-19 00:00:00

abstract：:Experimental and simulation studies show that small monomeric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends ...

journal_title：Nature

authors： Shakhnovich E,Abkevich V,Ptitsyn O

更新日期：1996-01-04 00:00:00