Molecular motors.


:Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide variety of cargo, power cell locomotion, drive cell division and, when combined in large ensembles, allow organisms to move. Motor defects can lead to severe diseases or may even be lethal. Basic principles of motor design and mechanism have now been derived, and an understanding of their complex cellular roles is emerging.






Schliwa M,Woehlke G





Has Abstract


2003-04-17 00:00:00
















  • Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf.

    abstract::Eukaryotic cells contain genes termed proto-oncogenes (c-onc) which have the potential to transform cells in culture and induce tumours in vivo. Most of these genes have been identified by their occasional incorporation into retroviral genomes which can act as natural transducing vectors for these and perhaps other ce...


    pub_type: 杂志文章


    authors: Sutrave P,Bonner TI,Rapp UR,Jansen HW,Patschinsky T,Bister K

    更新日期:1984-05-03 00:00:00

  • Genes required for GABA function in Caenorhabditis elegans.

    abstract::gamma-Aminobutyric acid (GABA) neurotransmission is widespread in vertebrate and invertebrate nervous systems. Here we use a genetic approach to identify molecules specific to GABA function. On the basis of the known in vivo roles of GABAergic neurons in controlling behaviour of the nematode Caenorhabditis elegans, we...


    pub_type: 杂志文章


    authors: McIntire SL,Jorgensen E,Horvitz HR

    更新日期:1993-07-22 00:00:00

  • Curare can open and block ionic channels associated with cholinergic receptors.

    abstract::Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is ab...


    pub_type: 杂志文章


    authors: Trautmann A

    更新日期:1982-07-15 00:00:00

  • Clathrate nanostructures for mass spectrometry.

    abstract::The ability of mass spectrometry to generate intact biomolecular ions efficiently in the gas phase has led to its widespread application in metabolomics, proteomics, biological imaging, biomarker discovery and clinical assays (namely neonatal screens). Matrix-assisted laser desorption/ionization (MALDI) and electrospr...


    pub_type: 杂志文章


    authors: Northen TR,Yanes O,Northen MT,Marrinucci D,Uritboonthai W,Apon J,Golledge SL,Nordström A,Siuzdak G

    更新日期:2007-10-25 00:00:00

  • Boosting slow oscillations during sleep potentiates memory.

    abstract::There is compelling evidence that sleep contributes to the long-term consolidation of new memories. This function of sleep has been linked to slow (<1 Hz) potential oscillations, which predominantly arise from the prefrontal neocortex and characterize slow wave sleep. However, oscillations in brain potentials are comm...


    pub_type: 临床试验,杂志文章


    authors: Marshall L,Helgadóttir H,Mölle M,Born J

    更新日期:2006-11-30 00:00:00

  • An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.

    abstract::The extent to which evolution is reversible has long fascinated biologists. Most previous work on the reversibility of morphological and life-history evolution has been indecisive, because of uncertainty and bias in the methods used to infer ancestral states for such characters. Further, despite theoretical work on th...


    pub_type: 杂志文章


    authors: Bridgham JT,Ortlund EA,Thornton JW

    更新日期:2009-09-24 00:00:00

  • Turbulent convective length scale in planetary cores.

    abstract::Convection is a fundamental physical process in the fluid cores of planets. It is the primary transport mechanism for heat and chemical species and the primary energy source for planetary magnetic fields. Key properties of convection-such as the characteristic flow velocity and length scale-are poorly quantified in pl...


    pub_type: 杂志文章


    authors: Guervilly C,Cardin P,Schaeffer N

    更新日期:2019-06-01 00:00:00

  • Coupled dynamics of body mass and population growth in response to environmental change.

    abstract::Environmental change has altered the phenology, morphological traits and population dynamics of many species. However, the links underlying these joint responses remain largely unknown owing to a paucity of long-term data and the lack of an appropriate analytical framework. Here we investigate the link between phenoty...


    pub_type: 杂志文章


    authors: Ozgul A,Childs DZ,Oli MK,Armitage KB,Blumstein DT,Olson LE,Tuljapurkar S,Coulson T

    更新日期:2010-07-22 00:00:00

  • HIV chemotherapy.

    abstract::The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced reductions in illness and death have been achieved and healthcare utilization has diminished. HIV therapy has also provided many new insights into the pathogenes...


    pub_type: 杂志文章,评审


    authors: Richman DD

    更新日期:2001-04-19 00:00:00

  • Ecosystem resilience despite large-scale altered hydroclimatic conditions.

    abstract::Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...


    pub_type: 历史文章,杂志文章


    authors: Ponce Campos GE,Moran MS,Huete A,Zhang Y,Bresloff C,Huxman TE,Eamus D,Bosch DD,Buda AR,Gunter SA,Scalley TH,Kitchen SG,McClaran MP,McNab WH,Montoya DS,Morgan JA,Peters DP,Sadler EJ,Seyfried MS,Starks PJ

    更新日期:2013-02-21 00:00:00

  • Density of hydrous silicate melt at the conditions of Earth's deep upper mantle.

    abstract::The chemical evolution of the Earth and the terrestrial planets is largely controlled by the density of silicate melts. If melt density is higher than that of the surrounding solid, incompatible elements dissolved in the melt will be sequestered in the deep mantle. Previous studies on dry (water-free) melts showed tha...


    pub_type: 杂志文章


    authors: Matsukage KN,Jing Z,Karato S

    更新日期:2005-11-24 00:00:00

  • Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.

    abstract::Heterozygous mutations in the X-linked MECP2 gene cause the neurological disorder Rett syndrome. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine. Functionally, MeCP2 has been implicated in several cellular processes on the basis ...


    pub_type: 杂志文章


    authors: Tillotson R,Selfridge J,Koerner MV,Gadalla KKE,Guy J,De Sousa D,Hector RD,Cobb SR,Bird A

    更新日期:2017-10-19 00:00:00

  • Solvent-induced distortions and the curvature of alpha-helices.

    abstract::The alpha-helix defined in 1951 by Pauling et al. on the basis of model building and X-ray fibre diffraction data has 3.65 residues per turn (n) achieved with planar peptides, torsion angles of phi = -48 degrees and psi = -57 degrees and hydrogen bonds which are close to linear. Although X-ray analyses of proteins hav...


    pub_type: 杂志文章


    authors: Blundell T,Barlow D,Borkakoti N,Thornton J

    更新日期:1983-11-17 00:00:00

  • Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.

    abstract::In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors. Continuing transcription of E2F target genes beyond the G1/S tr...


    pub_type: 杂志文章


    authors: Lukas C,Sørensen CS,Kramer E,Santoni-Rugiu E,Lindeneg C,Peters JM,Bartek J,Lukas J

    更新日期:1999-10-21 00:00:00

  • Positive interactions among alpine plants increase with stress.

    abstract::Plants can have positive effects on each other. For example, the accumulation of nutrients, provision of shade, amelioration of disturbance, or protection from herbivores by some species can enhance the performance of neighbouring species. Thus the notion that the distributions and abundances of plant species are inde...


    pub_type: 杂志文章


    authors: Callaway RM,Brooker RW,Choler P,Kikvidze Z,Lortie CJ,Michalet R,Paolini L,Pugnaire FI,Newingham B,Aschehoug ET,Armas C,Kikodze D,Cook BJ

    更新日期:2002-06-20 00:00:00

  • Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist.

    abstract::About one-third of human breast cancers require hormones for their continued growth and endocrine ablation or anti-hormone therapy can cause regression of these tumours. As a consequence, ovariectomy in premenopausal women or administration of an anti-oestrogen (tamoxifen) in postmenopausal women represent major optio...


    pub_type: 杂志文章


    authors: Miller WR,Scott WN,Morris R,Fraser HM,Sharpe RM

    更新日期:1985-01-17 00:00:00

  • Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.

    abstract::Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...


    pub_type: 杂志文章


    authors: Anacker C,Luna VM,Stevens GS,Millette A,Shores R,Jimenez JC,Chen B,Hen R

    更新日期:2018-07-01 00:00:00

  • Light-induced shape-memory polymers.

    abstract::Materials are said to show a shape-memory effect if they can be deformed and fixed into a temporary shape, and recover their original, permanent shape only on exposure to an external stimulus. Shape-memory polymers have received increasing attention because of their scientific and technological significance. In princi...


    pub_type: 杂志文章


    authors: Lendlein A,Jiang H,Jünger O,Langer R

    更新日期:2005-04-14 00:00:00

  • Rocket UV flash spectra from the solar eclipse of March 7, 1970.

    abstract::Flash spectra of the total solar eclipse throughout all its phases have been obtained in the extreme ultraviolet for the first time. ...


    pub_type: 杂志文章


    authors: Speer RJ,Garton WR,Morgan JF,Nicholls RW,Goldberg L,Parkinson WH,Reeves EM,Jones TJ,Paxton HJ,Shenton DB,Wilson R

    更新日期:1970-04-18 00:00:00

  • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.

    abstract::Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...


    pub_type: 杂志文章


    authors: Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

    更新日期:2010-11-11 00:00:00

  • Phenotypic consequences of 1,000 generations of selection at elevated CO2 in a green alga.

    abstract::Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...


    pub_type: 杂志文章


    authors: Collins S,Bell G

    更新日期:2004-09-30 00:00:00

  • Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.

    abstract::Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic trans...


    pub_type: 杂志文章


    authors: Hosie AM,Wilkins ME,da Silva HM,Smart TG

    更新日期:2006-11-23 00:00:00

  • Artificial charge-modulationin atomic-scale perovskite titanate superlattices.

    abstract::The nature and length scales of charge screening in complex oxides are fundamental to a wide range of systems, spanning ceramic voltage-dependent resistors (varistors), oxide tunnel junctions and charge ordering in mixed-valence compounds. There are wide variations in the degree of charge disproportionation, length sc...


    pub_type: 杂志文章


    authors: Ohtomo A,Muller DA,Grazul JL,Hwang HY

    更新日期:2002-09-26 00:00:00

  • Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.

    abstract::Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more ...


    pub_type: 杂志文章


    authors: Huff V,Compton DA,Chao LY,Strong LC,Geiser CF,Saunders GF

    更新日期:1988-11-24 00:00:00

  • Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.

    abstract::Botulinum neurotoxin A (BoNT/A) belongs to the most dangerous class of bioweapons. Despite this, BoNT/A is used to treat a wide range of common medical conditions such as migraines and a variety of ocular motility and movement disorders. BoNT/A is probably best known for its use as an antiwrinkle agent in cosmetic app...


    pub_type: 杂志文章


    authors: Benoit RM,Frey D,Hilbert M,Kevenaar JT,Wieser MM,Stirnimann CU,McMillan D,Ceska T,Lebon F,Jaussi R,Steinmetz MO,Schertler GF,Hoogenraad CC,Capitani G,Kammerer RA

    更新日期:2014-01-02 00:00:00

  • Occluded bound calcium on the phosphorylated sarcoplasmic transport ATPase.

    abstract::The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...


    pub_type: 杂志文章


    authors: Takisawa H,Makinose M

    更新日期:1981-03-19 00:00:00

  • Greater contribution to blood lead from water than from air.

    abstract::Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...


    pub_type: 杂志文章


    authors: Elwood PC,Gallacher JE,Phillips KM,Davies BE,Toothill C

    更新日期:1984-07-12 00:00:00

  • The Caenorhabditis elegans genome sequencing project: first steps in automation.

    abstract::Novel biochemical processes using magnetic particles have been automated to provide a robotic system to perform processes for large-scale shotgun sequencing. ...


    pub_type: 杂志文章


    authors: Watson A,Smaldon N,Lucke R,Hawkins T

    更新日期:1993-04-08 00:00:00

  • Water and its influence on the lithosphere-asthenosphere boundary.

    abstract::The Earth has distinctive convective behaviour, described by the plate tectonics model, in which lateral motion of the oceanic lithosphere of basaltic crust and peridotitic uppermost mantle is decoupled from the underlying mechanically weaker upper mantle (asthenosphere). The reason for differentiation at the lithosph...


    pub_type: 杂志文章


    authors: Green DH,Hibberson WO,Kovács I,Rosenthal A

    更新日期:2010-09-23 00:00:00

  • Visual but not trigeminal mediation of magnetic compass information in a migratory bird.

    abstract::Magnetic compass information has a key role in bird orientation, but the physiological mechanisms enabling birds to sense the Earth's magnetic field remain one of the unresolved mysteries in biology. Two biophysical mechanisms have become established as the most promising magnetodetection candidates. The iron-mineral-...


    pub_type: 杂志文章


    authors: Zapka M,Heyers D,Hein CM,Engels S,Schneider NL,Hans J,Weiler S,Dreyer D,Kishkinev D,Wild JM,Mouritsen H

    更新日期:2009-10-29 00:00:00