Peierls distortion as a route to high thermoelectric performance in In(4)Se(3-delta) crystals.

abstract：:Acyl carrier protein (ACP) transports the growing fatty acid chain between enzymatic domains of fatty acid synthase (FAS) during biosynthesis. Because FAS enzymes operate on ACP-bound acyl groups, ACP must stabilize and transport the growing lipid chain. ACPs have a central role in transporting starting materials and ...

journal_title：Nature

authors： Nguyen C,Haushalter RW,Lee DJ,Markwick PR,Bruegger J,Caldara-Festin G,Finzel K,Jackson DR,Ishikawa F,O'Dowd B,McCammon JA,Opella SJ,Tsai SC,Burkart MD

更新日期：2014-01-16 00:00:00

abstract：:Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant molecules, modern synthetic materials and commodity chemicals such as fuels and lubricants. Traditionally, the presence of a functional group is required at the site of C-C bond formation. Strategies that allow C-C bond formation...

journal_title：Nature

authors： Chu JC,Rovis T

更新日期：2016-11-10 00:00:00

abstract：:Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur. Pore-lining '...

journal_title：Nature

authors： Jiang Y,Lee A,Chen J,Cadene M,Chait BT,MacKinnon R

更新日期：2002-05-30 00:00:00

abstract：:The Gamburtsev Subglacial Mountains are the least understood tectonic feature on Earth, because they are completely hidden beneath the East Antarctic Ice Sheet. Their high elevation and youthful Alpine topography, combined with their location on the East Antarctic craton, creates a paradox that has puzzled researchers...

journal_title：Nature

authors： Ferraccioli F,Finn CA,Jordan TA,Bell RE,Anderson LM,Damaske D

更新日期：2011-11-16 00:00:00

abstract：:Large seasonal and hemispheric asymmetries in the martian climate system are generally ascribed to variations in solar heating associated with orbital eccentricity. As the orbital elements slowly change (over a period of >104 years), characteristics of the climate such as dustiness and the vigour of atmospheric circul...

journal_title：Nature

authors： Richardson MI,Wilson RJ

更新日期：2002-03-21 00:00:00

abstract：:During embryogenesis, body pattern is established in a stepwise process. After specification of the body axis, the embryo is subdivided into smaller units. Within these units, a diverse array of cell types is then generated. The subdivisions of the Drosophila embryo, called parasegments, are defined by the interface b...

journal_title：Nature

authors： Dougan S,DiNardo S

更新日期：1992-11-26 00:00:00

abstract：: ...

journal_title：Nature

authors： Maitra A

更新日期：2019-03-01 00:00:00

abstract：:Criteria for 'green buildings' need to make energy performance a priority--as do universities. ...

journal_title：Nature

authors：

更新日期：2009-09-10 00:00:00

abstract：:Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease. Numerous studies have dem...

journal_title：Nature

authors： Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M

更新日期：2014-02-27 00:00:00

abstract：:Transcription initiation factor TFIID is a multisubunit complex containing a TATA-box-binding factor (TFIID tau/TBP) and associated polypeptide factors (TAFs) with sizes ranging from M(r) approximately 20,000 to > 200,000. As a result of direct promoter interactions, TFIID nucleates the assembly of RNA polymerase II a...

journal_title：Nature

authors： Kokubo T,Gong DW,Wootton JC,Horikoshi M,Roeder RG,Nakatani Y

更新日期：1994-02-03 00:00:00

abstract：:The lysis of murine sarcoma virus-murine leukaemia virus (MSV-MuLV)-induced tumour cells by cytotoxic T lymphocytes (CTL) appears to require that an antigen specified by MSV-MuLV, or induced by the infection, be presented in association with class I major histocompatibility complex antigens. The viral proteins of the ...

journal_title：Nature

authors： Flyer DC,Burakoff SJ,Faller DV

更新日期：1983-10-27 00:00:00

abstract：:The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...

journal_title：Nature

authors： Pellegrini L,Tan S,Richmond TJ

更新日期：1995-08-10 00:00:00

abstract：:Change history: In Fig. 1c of this Letter, the two graphs were duplicates. The right panel of Fig. 1c has been corrected online. ...

journal_title：Nature

authors： Lai B,Gao W,Cui K,Xie W,Tang Q,Jin W,Hu G,Ni B,Zhao K

更新日期：2018-12-01 00:00:00

abstract：:The small martian satellites Phobos and Deimos orbit in synchronous rotation with inclinations of only 0.01 degrees and 0.92 degrees , respectively, relative to the planet's equatorial plane. Thus, an observer at near-equatorial latitudes on Mars could occasionally observe solar eclipses by these satellites (see ref. ...

journal_title：Nature

authors： Bell JF 3rd,Lemmon MT,Duxbury TC,Hubbard MY,Wolff MJ,Squyres SW,Craig L,Ludwinski JM

更新日期：2005-07-07 00:00:00

abstract：:Piwi-associated RNAs (piRNAs), a specific class of 24- to 30-nucleotide-long RNAs produced by the Piwi-type of Argonaute proteins, have a specific germline function in repressing transposable elements. This repression is thought to involve heterochromatin formation and transcriptional and post-transcriptional silencin...

journal_title：Nature

authors： Rouget C,Papin C,Boureux A,Meunier AC,Franco B,Robine N,Lai EC,Pelisson A,Simonelig M

更新日期：2010-10-28 00:00:00

abstract：:The signature of Dansgaard-Oeschger events--millennial-scale abrupt climate oscillations during the last glacial period--is well established in ice cores and marine records. But the effects of such events in continental settings are not as clear, and their absolute chronology is uncertain beyond the limit of (14)C dat...

journal_title：Nature

authors： Genty D,Blamart D,Ouahdi R,Gilmour M,Baker A,Jouzel J,Van-Exter S

更新日期：2003-02-20 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic trans...

journal_title：Nature

authors： Hosie AM,Wilkins ME,da Silva HM,Smart TG

更新日期：2006-11-23 00:00:00

abstract：:The nucleosome subunit of chromatin consists of DNA folded around a histone core as a 1.8-turn left-handed solenoid. The crystal structure of the nucleosome core particle revealed that it has a dyad symmetry axis and that the minor helix groove faces outwards from the protein core. Richmond et al. noticed that the pat...

journal_title：Nature

authors： Hogan ME,Rooney TF,Austin RH

更新日期：1987-08-06 00:00:00

abstract：:Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...

journal_title：Nature

authors： Galonić DP,Gin DY

更新日期：2007-04-26 00:00:00

abstract：:Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Protective antigen forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and...

journal_title：Nature

authors： Jiang J,Pentelute BL,Collier RJ,Zhou ZH

更新日期：2015-05-28 00:00:00

abstract：:Unilateral neglect following damage to the right hemisphere of the brain can be characterized by failure of the global attentional mechanisms of the right hemisphere to direct the local detail processors of the left hemisphere towards the contralesional left hemispace. This is suggested by patients who recognize the g...

journal_title：Nature

authors： Doricchi F,Incoccia C

更新日期：1998-07-02 00:00:00

abstract：:The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...

journal_title：Nature

authors： Havran WL,Allison JP

更新日期：1990-03-01 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:The study of the extent and basis of gene-enzyme variation has long been a principal concern of population genetics. Numerous surveys have indicated considerable amounts of genetic variation detectable in natural populations, with few exceptions. The variances of average heterozygosities (H) between species and among ...

journal_title：Nature

authors： O'Brien SJ,Gail MH,Levin DL

更新日期：1980-12-11 00:00:00

abstract：: ...

journal_title：Nature

authors： Lewis-Jones H

更新日期：2018-11-01 00:00:00

abstract：:Acyclovir (9-[2-hydroxyethoxymethyl]guanine or ACV) is a nucleoside analogue with considerable potential for the treatment of herpes simplex virus (HSV) infections in man. Two virus-coded enzymes are important in the mechanism of action of this drug: thymidine kinase (TK) which initiates its activation by converting i...

journal_title：Nature

authors： Darby G,Field HJ,Salisbury SA

更新日期：1981-01-01 00:00:00

abstract：:Oxygen consumption by carnivorous reptiles increases enormously after they have eaten a large meal in order to meet metabolic demands, and this places an extra load on the cardiovascular system. Here we show that there is an extraordinarily rapid 40% increase in ventricular muscle mass in Burmese pythons (Python molur...

journal_title：Nature

authors： Andersen JB,Rourke BC,Caiozzo VJ,Bennett AF,Hicks JW

更新日期：2005-03-03 00:00:00

abstract：:Since the pioneering work of the Millers it has become clear that most chemical carcinogens require metabolism to reactive electrophiles and then exhibit their carcinogenic potential by reacting chemically with, and modifying, cellular macromolecules. At first modification of proteins was considered most likely to be ...

journal_title：Nature

authors： Allen JA,Coombs MM

更新日期：1980-09-18 00:00:00

abstract：:During embryonic development, orderly patterns of gene expression eventually assign each cell in the embryo its particular fate. For the anteroposterior axis of the Drosophila embryo, the first step in this process depends on a spatial gradient of the maternal morphogen Bicoid (Bcd). Positional information of this gra...

journal_title：Nature

authors： Houchmandzadeh B,Wieschaus E,Leibler S

更新日期：2002-02-14 00:00:00