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NATURE文献大全abstract::The existence of prostate stem cells (PSCs) was first postulated from the observation that normal prostate regeneration can occur after repeated cycles of androgen deprivation and replacement in rodents. Given the critical role of PSCs in maintaining prostate tissue integrity and their potential involvement in prostat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07427
更新日期:2008-12-11 00:00:00
abstract::The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0571-7
更新日期:2018-10-01 00:00:00
abstract::Understanding crystal growth is essential for controlling the crystallization used in industrial separation and purification processes. Because solids interact through their surfaces, crystal shape can influence both chemical and physical properties. The thermodynamic morphology can readily be predicted, but most part...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04173
更新日期:2005-11-03 00:00:00
abstract::Folding of two monomeric enzymes mediated by groE has been reconstituted in vitro. The groEL protein stabilizes the polypeptides in a conformation resembling the 'molten globule' state. Mg-ATP and groES then promote the acquisition of ordered tertiary structure at the surface of groEL. Folding requires the hydrolysis ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352036a0
更新日期:1991-07-04 00:00:00
abstract::A long-sought goal in structural biology has been the imaging of membrane proteins in their membrane environments. This goal has been achieved with electron crystallography in those special cases where a protein forms highly ordered arrays in lipid bilayers. It has also been achieved by NMR methods in proteins up to 5...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08291
更新日期:2009-09-10 00:00:00
abstract::High-pressure transitions are thought to modify hydrogen molecules to a molecular metallic solid and finally to an atomic metal1, which is predicted to have exotic physical properties and the topology of a two-component (electron and proton) superconducting superfluid condensate2,3. Therefore, understanding such trans...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1565-9
更新日期:2019-09-01 00:00:00
abstract::Reactive oxygen species trigger cellular responses by activation of stress-responsive mitogen-activated protein kinase (MAPK) signalling pathways. Reversal of MAPK activation requires the transcriptional induction of specialized cysteine-based phosphatases that mediate MAPK dephosphorylation. Paradoxically, oxidative ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05804
更新日期:2007-05-24 00:00:00
abstract::The National Institutes of Health's Recombinant DNA Advisory Committee (RAC) has approved a commercial proposal by Advanced Genetic Sciences Inc. to field-test recombinant ice-nucleating bacteria. Its decision came two weeks after a federal judge halted a similar trial by researchers from the University of California...
journal_title:Nature
pub_type: 新闻
doi:10.1038/309483a0
更新日期:1984-06-07 00:00:00
abstract::During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature09228
更新日期:2010-06-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-020-2691-0
更新日期:2020-09-01 00:00:00
abstract::Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04352
更新日期:2006-01-12 00:00:00
abstract::Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for dis...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021239
更新日期:2000-08-17 00:00:00
abstract::Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0497-0
更新日期:2018-09-01 00:00:00
abstract::Cell and lipid membranes are able to bend, as manifested during membrane fusion and the formation of non-lamellar lyotropic mesophases in water. But there is an energy cost to bending of lipid layers, called the curvature elastic energy. Although the functional form of this energy is known, a complete quantitative kno...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/368224a0
更新日期:1994-03-17 00:00:00
abstract::Chronic myelogenous leukaemia (CML) is a clonal disease arising from malignant transformation of pluripotent hematopoietic stem cells. In most cases, it is characterized by the presence of the Philadelphia (Ph1) chromosome (22q-) which results from a reciprocal translocation between chromosomes 9 and 22 (refs 1-3). In...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/319331a0
更新日期:1986-01-23 00:00:00
abstract::The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353353a0
更新日期:1991-09-26 00:00:00
abstract::Natural composite materials are renowned for their mechanical strength and toughness: despite being highly mineralized, with the organic component constituting not more than a few per cent of the composite material, the fracture toughness exceeds that of single crystals of the pure mineral by two to three orders of ma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35016535
更新日期:2000-06-29 00:00:00
abstract::It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/311271a0
更新日期:1984-09-20 00:00:00
abstract::The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid separation until all chromosomes have achieved bipolar attachment to the mitotic spindle. Its operation is essential for accurate chromosome segregation, whereas its dysregulation can contribute to birth defects and tumorigenesis. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05694
更新日期:2007-04-19 00:00:00
abstract::In the coming decades, a crucial challenge for humanity will be meeting future food demands without undermining further the integrity of the Earth's environmental systems. Agricultural systems are already major forces of global environmental degradation, but population growth and increasing consumption of calorie- and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11420
更新日期:2012-10-11 00:00:00
abstract::Published data from X-ray telescopes are not adequate to reveal the fluctuations in the surface brightness of the background radiation caused by clustering or superclustering of the sources giving rise to the background. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/238020a0
更新日期:1972-07-07 00:00:00
abstract::Reported widespread declines of wild and managed insect pollinators have serious consequences for global ecosystem services and agricultural production. Bees contribute approximately 80% of insect pollination, so it is important to understand and mitigate the causes of current declines in bee populations . Recent stud...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11585
更新日期:2012-11-01 00:00:00
abstract::The monarch butterfly, Danaus plexippus, is famous for its spectacular annual migration across North America, recent worldwide dispersal, and orange warning colouration. Despite decades of study and broad public interest, we know little about the genetic basis of these hallmark traits. Here we uncover the history of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13812
更新日期:2014-10-16 00:00:00
abstract::The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07810
更新日期:2009-03-12 00:00:00
abstract::RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/364550a0
更新日期:1993-08-05 00:00:00
abstract::The receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction. Igf2/Mpr has been mapped to the mouse Tme locus and shown to be an imprinte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372464a0
更新日期:1994-12-01 00:00:00
abstract::The human sex chromosomes share a pair of homologous genes which independently encode a cell-surface antigen defined by the monoclonal antibody 12E7 (refs 1, 2; see refs 3, 4 for review). The X-located homologue, MIC2X, escapes X-inactivation and the equivalent Y-located locus, MIC2Y, was one of the first genes shown ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317739a0
更新日期:1985-10-24 00:00:00
abstract::The outcomes of evolution are determined by a stochastic dynamical process that governs how mutations arise and spread through a population. However, it is difficult to observe these dynamics directly over long periods and across entire genomes. Here we analyse the dynamics of molecular evolution in twelve experimenta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24287
更新日期:2017-11-02 00:00:00
abstract::Quantum degenerate Fermi gases provide a remarkable opportunity to study strongly interacting fermions. In contrast to other Fermi systems, such as superconductors, neutron stars or the quark-gluon plasma of the early Universe, these gases have low densities and their interactions can be precisely controlled over an e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03858
更新日期:2005-06-23 00:00:00
abstract::Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10244
更新日期:2011-07-20 00:00:00