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NATURE文献大全abstract::The tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents. As p53 is a transcriptional activator that mediates gene induction after DNA damage, it has been proposed to be a genetic switch that activates apoptosis-mediator genes. Here we evaluate the role of p53 in DNA-dam...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370220a0
更新日期:1994-07-21 00:00:00
abstract::Muscle force is generated by myosin crossbridges interacting with actin. As estimated from stiffness and equatorial X-ray diffraction of muscle and muscle fibres, most myosin crossbridges are attached to actin during isometric contraction, but a much smaller fraction is bound stereospecifically. To determine the fract...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40651
更新日期:1997-07-10 00:00:00
abstract::Originally described by Lugaresi et al. in 1986 (ref. 1), fatal familial insomnia (FFI) is a rare inherited neurological disease characterized by the subacute progression of intractable insomnia and other autonomic abnormalities, cerebellar and pyramidal signs, myoclonus and dementia; neuropathologically, the major fe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376434a0
更新日期:1995-08-03 00:00:00
abstract::Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376788a0
更新日期:1995-08-31 00:00:00
abstract::Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00997
更新日期:2002-09-05 00:00:00
abstract::Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation1,2. How cells ensure that recombination occurs in the PAR is unknown. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2327-4
更新日期:2020-06-01 00:00:00
abstract::Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13608
更新日期:2014-09-04 00:00:00
abstract::Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or posing a risk of hypoglycaemia. For over half a century, this agent has been prescribed to patients wit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13270
更新日期:2014-06-26 00:00:00
abstract::Neuropeptide Y (NPY) has a number of functions in mammalian physiology. Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support. Mice wit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35073601
更新日期:2001-04-19 00:00:00
abstract::The recent discovery of a pterosaur egg with embryonic skeleton and soft tissues from the Yixian Formation confirmed that the flying pterosaurs were oviparous. Here we describe another pterosaur egg whose exquisite preservation indicates that the shell structure was soft and leathery. ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/432572a
更新日期:2004-12-02 00:00:00
abstract::Diminishing fossil fuel reserves and growing concerns about global warming indicate that sustainable sources of energy are needed in the near future. For fuels to be useful in the transportation sector, they must have specific physical properties that allow for efficient distribution, storage and combustion; these pro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05923
更新日期:2007-06-21 00:00:00
abstract::The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we directly test for increased transcriptional noise in aged tissue by di...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04844
更新日期:2006-06-22 00:00:00
abstract::Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-018-0171-6
更新日期:2018-06-01 00:00:00
abstract::Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-020-2729-3
更新日期:2020-09-01 00:00:00
abstract::The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35014569
更新日期:2000-06-01 00:00:00
abstract::For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature07361
更新日期:2008-10-09 00:00:00
abstract::In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353267a0
更新日期:1991-09-19 00:00:00
abstract::The interaction of lectins with carbohydrate receptors on the plasma membrane of eukaryotic cells results in a wide variety of biological effects. One effect which has been extensively studied is the stimulation of lymphocytes to blastogenesis and proliferation. High doses of concanavalin A (Con A) and phytohaemagglut...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/284273a0
更新日期:1980-03-20 00:00:00
abstract::The spacing of opening-mode fractures in layered materials--such as certain sedimentary rocks and laminated engineering materials--is often proportional to the thickness of the fractured layer. Experimental studies of this phenomenon show that the spacing initially decreases as extensional strain increases in the dire...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35001550
更新日期:2000-02-17 00:00:00
abstract::Regulatory T (T(reg)) cells are a critical sub-population of CD4+ T cells that are essential for maintaining self tolerance and preventing autoimmunity, for limiting chronic inflammatory diseases, such as asthma and inflammatory bowel disease, and for regulating homeostatic lymphocyte expansion. However, they also sup...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06306
更新日期:2007-11-22 00:00:00
abstract::Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...
journal_title:Nature
pub_type: 信件
doi:10.1038/nature04788
更新日期:2006-06-29 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00567-2
更新日期:2019-02-01 00:00:00
abstract::Monocular lid suture during the sensitive period early in the life of a kitten disrupts normal development of inputs from the two eyes to the visual cortex, causing a decrease in the fraction of cortical cells responding to the deprived eye. Such an ocular dominance shift has been assumed to depend on patterned visual...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324154a0
更新日期:1986-11-13 00:00:00
abstract::Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343092a0
更新日期:1990-01-04 00:00:00
abstract::A connection between thunderstorms and the ionosphere has been hypothesized since the mid-1920s. Several mechanisms have been proposed to explain this connection, and evidence from modelling as well as various types of measurements demonstrate that lightning can interact with the lower ionosphere. It has been proposed...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03638
更新日期:2005-06-09 00:00:00
abstract::Some beetles in the Namib Desert collect drinking water from fog-laden wind on their backs. We show here that these large droplets form by virtue of the insect's bumpy surface, which consists of alternating hydrophobic, wax-coated and hydrophilic, non-waxy regions. The design of this fog-collecting structure can be re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35102108
更新日期:2001-11-01 00:00:00
abstract::Amino-acid radicals play key roles in many enzymatic reactions. Catalysis often involves transfer of a radical character within the protein, as in class I ribonucleotide reductase where radical transfer occurs over 35 A, from a tyrosyl radical to a cysteine. It is currently debated whether this kind of long-range tran...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35014644
更新日期:2000-06-01 00:00:00
abstract::The reciprocal chromosome translocation, t(8;14), involving the heavy chain locus on chromosome 14 and the c-myc oncogene on chromosome 8 is a characteristic of the B-cell malignancies Burkitt's lymphoma and acute lymphoblastic leukaemia (ALL). We have cloned and sequenced the t(8; 14) breakpoints of an African Burkit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324158a0
更新日期:1986-11-13 00:00:00
abstract::The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradictio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/383350a0
更新日期:1996-09-26 00:00:00
abstract::In order to direct a movement towards a visual stimulus, visual spatial information must be combined with postural information. For example, directing gaze (eye plus head) towards a visible target requires the combination of retinal image location with eye and head position to determine the location of the target rela...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29777
更新日期:1998-08-27 00:00:00