Abstract：
:For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing the most severe type of human malaria, was completed, eliminating many of the barriers to performing state-of-the-art molecular biological research on malaria parasites. Although new, licensed therapies may not yet have resulted from genome-dependent experiments, they have produced a wealth of new observations about the basic biology of malaria parasites, and it is likely that these will eventually lead to new therapeutic approaches. This review will focus on the basic research discoveries that have depended, in part, on the availability of the Plasmodium genome sequences.
journal_name
Naturejournal_title
Natureauthors
Winzeler EAdoi
10.1038/nature07361subject
Has Abstractpub_date
2008-10-09 00:00:00pages
751-6issue
7214eissn
0028-0836issn
1476-4687pii
nature07361journal_volume
455pub_type
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