Abstract:
:The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more than 50 years (175 generations). The population genetic structures of the Swiss mouse colonies were comparable to an island population in which random fixation, and not inbreeding or population bottlenecks, is apparently responsible for slight losses in genetic variance.
journal_name
Naturejournal_title
Natureauthors
Rice MC,O'Brien SJdoi
10.1038/283157a0subject
Has Abstractpub_date
1980-01-10 00:00:00pages
157-61issue
5743eissn
0028-0836issn
1476-4687journal_volume
283pub_type
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