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NATURE文献大全abstract::T-cell lines established from individuals infected with human T-cell leukaemia virus (HTLV) or generated by co-cultivation of normal human T cells with HTLV-infected T-cells, express class II (HLA-D/DR or Ia) antigens of the major histocompatibility complex (MHC) and interleukin-2 (IL-2) receptors. Because the express...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/312275a0
更新日期:1984-11-15 00:00:00
abstract::Continental rifts are important sources of mantle carbon dioxide (CO2) emission into Earth's atmosphere1-3. Because deep carbon is stored for long periods in the lithospheric mantle4-6, rift CO2 flux depends on lithospheric processes that control melt and volatile transport1,3,7. The influence of compositional and thi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2328-3
更新日期:2020-06-01 00:00:00
abstract::Over the past decade, ice loss from the Greenland Ice Sheet increased as a result of both increased surface melting and ice discharge to the ocean. The latter is controlled by the acceleration of ice flow and subsequent thinning of fast-flowing marine-terminating outlet glaciers. Quantifying the future dynamic contrib...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12068
更新日期:2013-05-09 00:00:00
abstract::The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported (see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05825
更新日期:2007-06-14 00:00:00
abstract::Deuterostomes are a remarkably diverse super-phylum, including not only the chordates (to which we belong) but groups as disparate as the echinoderms and the hemichordates. The phylogeny of deuterostomes is now achieving some degree of stability, especially on account of new molecular data, but this leaves as conjectu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02648
更新日期:2004-07-22 00:00:00
abstract::Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07341
更新日期:2008-10-30 00:00:00
abstract::The sequence-specific DNA-binding protein, MyoD, can activate muscle-specific gene expression in some cells in culture. Xenopus MyoD (XMyoD) transcription is activated as a consequence of mesoderm induction in the early myotomes, from which the axial musculature develops. XMyoD RNA accumulates about two hours before m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347197a0
更新日期:1990-09-13 00:00:00
abstract::In the response of T cells to foreign antigens, the ligand for the T cell alpha/beta receptor is presented on a cell surface as a fragment of antigen complexed to one of the membrane molecules encoded in the major histocompatibility complex (MHC). The receptor apparently interacts via its variable elements (V beta, D ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332840a0
更新日期:1988-04-28 00:00:00
abstract::Calcium (Ca(2+))-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remain...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07313
更新日期:2008-10-30 00:00:00
abstract::The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03845
更新日期:2005-08-11 00:00:00
abstract::Optical-frequency synthesizers, which generate frequency-stable light from a single microwave-frequency reference, are revolutionizing ultrafast science and metrology, but their size, power requirement and cost need to be reduced if they are to be more widely used. Integrated-photonics microchips can be used in high-c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0065-7
更新日期:2018-05-01 00:00:00
abstract::The diverse functions of RNA, which include enzymatic activities, regulatory roles in transcription and translation, are made possible by tertiary structure. Computer algorithms can predict the secondary structure of an RNA molecule using free-energy parameters for base pairing and stacking, loops and bulges. However,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331283a0
更新日期:1988-01-21 00:00:00
abstract::The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon guidance. Here we describe a phenotype-based gene-trap screen in mice designed for the large-scale i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35065539
更新日期:2001-03-08 00:00:00
abstract::Maize smut caused by the fungus Ustilago maydis is a widespread disease characterized by the development of large plant tumours. U. maydis is a biotrophic pathogen that requires living plant tissue for its development and establishes an intimate interaction zone between fungal hyphae and the plant plasma membrane. U. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10454
更新日期:2011-10-05 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07804-0
更新日期:2018-12-01 00:00:00
abstract::Although stars form from clouds of gas and dust, there are insignificant amounts of gas around ordinary (Sun-like) stars. This suggests that hydrogen and helium, the primary constituents of planets such as Jupiter and Saturn, are not easily retained in orbit as a star matures. The gas-giant planets in the Solar System...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373494a0
更新日期:1995-02-09 00:00:00
abstract::In information processing, as in physics, our classical world view provides an incomplete approximation to an underlying quantum reality. Quantum effects like interference and entanglement play no direct role in conventional information processing, but they can--in principle now, but probably eventually in practice--b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35005001
更新日期:2000-03-16 00:00:00
abstract::A hemispheric dichotomy on Mars is marked by the sharp contrast between the sparsely cratered northern lowland plains and the heavily cratered southern highlands. Mechanisms proposed to remove ancient crust or form younger lowland crust include one or more giant impacts, subcrustal transport by mantle convection, the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05356
更新日期:2006-12-14 00:00:00
abstract::Since the initial discovery that the DNase I sensitivity of the globin genes in different cell types correlates with globin gene expression, this relationship has been shown to hold true for a variety of genes, including the genes for ovalbumin, conalbumun, alpha- and beta-globin in chicken, several heat-shock protein...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298578a0
更新日期:1982-08-05 00:00:00
abstract::A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/226330a0
更新日期:1970-04-25 00:00:00
abstract::The nuclear envelope defines a compartment boundary which is penetrated by pores that mediate a remarkable transport process. Precursor RNAs are retained in the nucleus, while processed messenger RNA, transfer RNA and ribosomal subunits are transported to the cytoplasm. Proteins destined for the nucleus become localiz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322641a0
更新日期:1986-08-14 00:00:00
abstract::Xenoturbellida and Acoelomorpha are marine worms with contentious ancestry. Both were originally associated with the flatworms (Platyhelminthes), but molecular data have revised their phylogenetic positions, generally linking Xenoturbellida to the deuterostomes and positioning the Acoelomorpha as the most basally bran...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09676
更新日期:2011-02-10 00:00:00
abstract::Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contrast to alphabeta TCRs, which recognize antigen only as peptide fragme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35172
更新日期:1998-01-29 00:00:00
abstract::The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1703-4
更新日期:2019-11-01 00:00:00
abstract::Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTO...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08221
更新日期:2009-07-16 00:00:00
abstract::Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possibl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03115-5
更新日期:2021-01-06 00:00:00
abstract::Activity-induced changes in the efficacy of synaptic transmission between neurones are central to several prominent theories of learning. In both in vivo and in vitro preparations of the hippocampus, a conditioning high-frequency stimulus delivered to afferent fibres results in a long-term potentiation of synaptic tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320529a0
更新日期:1986-04-10 00:00:00
abstract::X-chromosome inactivation results in the strictly cis-limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females. One feature of virtually all models of X inactivation is the existence of an X-inactivation centre (XIC) required in cis f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/349082a0
更新日期:1991-01-03 00:00:00
abstract::The origin of eukaryotes stands as a major conundrum in biology. Current evidence indicates that the last eukaryotic common ancestor already possessed many eukaryotic hallmarks, including a complex subcellular organization. In addition, the lack of evolutionary intermediates challenges the elucidation of the relative ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16941
更新日期:2016-03-03 00:00:00
abstract::A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-depende...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346369a0
更新日期:1990-07-26 00:00:00