Biodiversity loss is dire, don't get distracted.








Davies J,Stoett P





2018-12-01 00:00:00
















  • Synthesis of epothilones A and B in solid and solution phase.

    abstract::Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molec...


    pub_type: 杂志文章


    authors: Nicolaou KC,Winssinger N,Pastor J,Ninkovic S,Sarabia F,He Y,Vourloumis D,Yang Z,Li T,Giannakakou P,Hamel E

    更新日期:1997-05-15 00:00:00

  • A network that learns to recognize three-dimensional objects.

    abstract::The visual recognition of three-dimensional (3-D) objects on the basis of their shape poses at least two difficult problems. First, there is the problem of variable illumination, which can be addressed by working with relatively stable features such as intensity edges rather than the raw intensity images. Second, ther...


    pub_type: 杂志文章


    authors: Poggio T,Edelman S

    更新日期:1990-01-18 00:00:00

  • Man-made antibodies.

    abstract::Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extende...


    pub_type: 杂志文章,评审


    authors: Winter G,Milstein C

    更新日期:1991-01-24 00:00:00

  • Polymer-supported membranes as models of the cell surface.

    abstract::Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering a...


    pub_type: 杂志文章,评审


    authors: Tanaka M,Sackmann E

    更新日期:2005-09-29 00:00:00

  • Post-Jurassic mammal-like reptile from the Palaeocene.

    abstract::Mammal-like reptiles of the order Therapsida document the emergence of mammals from more primitive synapsids and are of unique zoological and palaeontological interest on that account. Therapsids, first appearing in the Early Permian, were thought to become extinct in the Middle Jurassic, soon after the Late Triassic ...


    pub_type: 杂志文章


    authors: Fox RC,Youzwyshyn GP,Krause DW

    更新日期:1992-07-16 00:00:00

  • Mesozoic plate-motion history below the northeast Pacific Ocean from seismic images of the subducted Farallon slab

    abstract::The high-resolution seismic imaging of subducted oceanic slabs has become a powerful tool for reconstructing palaeogeography. The images can now be interpreted quantitatively by comparison with models of the general circulation of the Earth's mantle. Here we use a three-dimensional spherical computer model of mantle c...


    pub_type: 杂志文章


    authors: Bunge HP,Grand SP

    更新日期:2000-05-18 00:00:00

  • Do 'lipidic particles' represent intermembrane attachment sites?

    abstract::Although freeze-fracture electron microscopy is normally analysed with the presumption that particles represent proteins embedded within the membrane, particles which appeared to represent inverted lipid micelles within membranes have been reported. I have now confirmed the occurrence of particles in protein-free lipo...


    pub_type: 杂志文章


    authors: Miller RG

    更新日期:1980-09-11 00:00:00

  • High-resolution tunnelling spectroscopy of a graphene quartet.

    abstract::Electrons in a single sheet of graphene behave quite differently from those in traditional two-dimensional electron systems. Like massless relativistic particles, they have linear dispersion and chiral eigenstates. Furthermore, two sets of electrons centred at different points in reciprocal space ('valleys') have this...


    pub_type: 杂志文章


    authors: Song YJ,Otte AF,Kuk Y,Hu Y,Torrance DB,First PN,de Heer WA,Min H,Adam S,Stiles MD,MacDonald AH,Stroscio JA

    更新日期:2010-09-09 00:00:00

  • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.

    abstract::In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose-Glut4(-/-)) mice show insulin resistance secondarily in muscle and liver. Here we show, using DNA arrays, that expression of retinol bindin...


    pub_type: 杂志文章


    authors: Yang Q,Graham TE,Mody N,Preitner F,Peroni OD,Zabolotny JM,Kotani K,Quadro L,Kahn BB

    更新日期:2005-07-21 00:00:00

  • A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells.

    abstract::The CD4 subset of cells displays helper/inducer activity and recognizes class II antigens of the major histocompatibility complex (MHC), while the CD8 subset recognizes class I MHC antigens and exhibits cytotoxic or suppressor function. Considerable functional as well as corresponding phenotypic heterogeneity exists w...


    pub_type: 杂志文章


    authors: Morimoto C,Rudd CE,Letvin NL,Schlossman SF

    更新日期:1987-12-03 00:00:00

  • An intermediate-mass black hole of over 500 solar masses in the galaxy ESO 243-49.

    abstract::Ultraluminous X-ray sources are extragalactic objects located outside the nucleus of the host galaxy with bolometric luminosities exceeding 10(39) erg s(-1). These extreme luminosities-if the emission is isotropic and below the theoretical (Eddington) limit, where the radiation pressure is balanced by the gravitationa...


    pub_type: 杂志文章


    authors: Farrell SA,Webb NA,Barret D,Godet O,Rodrigues JM

    更新日期:2009-07-02 00:00:00

  • Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury.

    abstract::Ciliary neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor. The identificatio...


    pub_type: 杂志文章


    authors: Curtis R,Adryan KM,Zhu Y,Harkness PJ,Lindsay RM,DiStefano PS

    更新日期:1993-09-16 00:00:00

  • Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.

    abstract::Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...


    pub_type: 杂志文章


    authors: Charpak S,Gähwiler BH,Do KQ,Knöpfel T

    更新日期:1990-10-25 00:00:00

  • Processing of tumour necrosis factor-alpha precursor by metalloproteinases.

    abstract::Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis and the cachexia associated with cancer or human immunodeficiency virus infection. TNF-alpha is initially expressed...


    pub_type: 杂志文章


    authors: Gearing AJ,Beckett P,Christodoulou M,Churchill M,Clements J,Davidson AH,Drummond AH,Galloway WA,Gilbert R,Gordon JL

    更新日期:1994-08-18 00:00:00

  • Structure of paused transcription complex Pol II-DSIF-NELF.

    abstract::Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy structure of a paused transcr...


    pub_type: 杂志文章


    authors: Vos SM,Farnung L,Urlaub H,Cramer P

    更新日期:2018-08-01 00:00:00

  • Complex hybrid origin of genetic caste determination in harvester ants.

    abstract::Caste differentiation and division of labour are the hallmarks of insect societies and at the root of their ecological success. Kin selection predicts that caste determination should result from environmentally induced differences in gene expression, a prediction largely supported by empirical data. However, two excep...


    pub_type: 杂志文章


    authors: Helms Cahan S,Keller L

    更新日期:2003-07-17 00:00:00

  • A primitive placoderm sheds light on the origin of the jawed vertebrate face.

    abstract::Extant vertebrates form two clades, the jawless Cyclostomata (lampreys and hagfishes) and the jawed Gnathostomata (all other vertebrates), with contrasting facial architectures. These arise during development from just a few key differences in the growth patterns of the cranial primordia: notably, the nasal sacs and h...


    pub_type: 杂志文章


    authors: Dupret V,Sanchez S,Goujet D,Tafforeau P,Ahlberg PE

    更新日期:2014-03-27 00:00:00

  • A four-helix bundle stores copper for methane oxidation.

    abstract::Methane-oxidizing bacteria (methanotrophs) require large quantities of copper for the membrane-bound (particulate) methane monooxygenase. Certain methanotrophs are also able to switch to using the iron-containing soluble methane monooxygenase to catalyse methane oxidation, with this switchover regulated by copper. Met...


    pub_type: 杂志文章


    authors: Vita N,Platsaki S,Baslé A,Allen SJ,Paterson NG,Crombie AT,Murrell JC,Waldron KJ,Dennison C

    更新日期:2015-09-03 00:00:00

  • Reverse and forward engineering of Drosophila corneal nanocoatings.

    abstract::Insect eyes have an anti-reflective coating, owing to nanostructures on the corneal surface creating a gradient of refractive index between that of air and that of the lens material1,2. These nanocoatings have also been shown to provide anti-adhesive functionality3. The morphology of corneal nanocoatings are very dive...


    pub_type: 杂志文章


    authors: Kryuchkov M,Bilousov O,Lehmann J,Fiebig M,Katanaev VL

    更新日期:2020-09-01 00:00:00

  • Simulation of Hubbard model physics in WSe2/WS2 moiré superlattices.

    abstract::The Hubbard model, formulated by physicist John Hubbard in the 1960s1, is a simple theoretical model of interacting quantum particles in a lattice. The model is thought to capture the essential physics of high-temperature superconductors, magnetic insulators and other complex quantum many-body ground states2,3. Althou...


    pub_type: 杂志文章


    authors: Tang Y,Li L,Li T,Xu Y,Liu S,Barmak K,Watanabe K,Taniguchi T,MacDonald AH,Shan J,Mak KF

    更新日期:2020-03-01 00:00:00

  • Occluded bound calcium on the phosphorylated sarcoplasmic transport ATPase.

    abstract::The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...


    pub_type: 杂志文章


    authors: Takisawa H,Makinose M

    更新日期:1981-03-19 00:00:00

  • Perennial N2 supersaturation in an Antarctic lake.

    abstract::The dry valleys of southern Victoria Land in Antarctica contain several closed basins in which perennially ice-covered lakes are found. One of the most unusual features of these lakes is the occurrence of high O2 concentrations in the water column; values ranging from slightly more than saturation to more than four t...


    pub_type: 杂志文章


    authors: Wharton RA Jr,McKay CP,Mancinelli RL,Simmons GM Jr

    更新日期:1987-01-22 00:00:00

  • 3-A resolution structure of a protein with histone-like properties in prokaryotes.

    abstract::The 3-A structure of DNA-binding protein II, which exhibits histone-like properties in bacteria, has been determined. The molecule is dimeric and appears to bind to the phosphate backbone of DNA through two symmetry-related arms. A mechanism by which the protein induces DNA supercoiling is proposed. ...


    pub_type: 杂志文章


    authors: Tanaka I,Appelt K,Dijk J,White SW,Wilson KS

    更新日期:1984-08-02 00:00:00

  • Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

    abstract::Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption1. Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers1,2. Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which whe...


    pub_type: 杂志文章


    authors: Hodskinson MR,Bolner A,Sato K,Kamimae-Lanning AN,Rooijers K,Witte M,Mahesh M,Silhan J,Petek M,Williams DM,Kind J,Chin JW,Patel KJ,Knipscheer P

    更新日期:2020-03-01 00:00:00

  • Ultraviolet emissions from the magnetic footprints of Io, Ganymede and Europa on Jupiter.

    abstract::Io leaves a magnetic footprint on Jupiter's upper atmosphere that appears as a spot of ultraviolet emission that remains fixed underneath Io as Jupiter rotates. The specific physical mechanisms responsible for generating those emissions are not well understood, but in general the spot seems to arise because of an elec...


    pub_type: 杂志文章


    authors: Clarke JT,Ajello J,Ballester G,Ben Jaffel L,Connerney J,Gérard JC,Gladstone GR,Grodent D,Pryor W,Trauger J,Waite JH Jr

    更新日期:2002-02-28 00:00:00

  • A resource for cell line authentication, annotation and quality control.

    abstract::Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of sy...


    pub_type: 杂志文章


    authors: Yu M,Selvaraj SK,Liang-Chu MM,Aghajani S,Busse M,Yuan J,Lee G,Peale F,Klijn C,Bourgon R,Kaminker JS,Neve RM

    更新日期:2015-04-16 00:00:00

  • Visual synchrony affects binding and segmentation in perception.

    abstract::The visual system analyses information by decomposing complex objects into simple components (visual features) that are widely distributed across the cortex. When several objects are present simultaneously in the visual field, a mechanism is required to group (bind) together visual features that belong to each object ...


    pub_type: 杂志文章


    authors: Usher M,Donnelly N

    更新日期:1998-07-09 00:00:00

  • A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.

    abstract::In metazoans, the Ras-Raf-MEK (mitogen-activated protein-kinase kinase)-ERK (extracellular signal-regulated kinase) signalling pathway relays extracellular stimuli to elicit changes in cellular function and gene expression. Aberrant activation of this pathway through oncogenic mutations is responsible for a large prop...


    pub_type: 杂志文章


    authors: Brennan DF,Dar AC,Hertz NT,Chao WC,Burlingame AL,Shokat KM,Barford D

    更新日期:2011-04-21 00:00:00

  • HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

    abstract::The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it remains unknown whether a mechanism exists that integrates these nucleic-acid-sensing systems. Here we sho...


    pub_type: 杂志文章


    authors: Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T

    更新日期:2009-11-05 00:00:00

  • Granular materials: packing grains by thermal cycling.

    abstract::A long-standing problem in managing the behaviour of a collection of solid grains concerns the nature of the grain packing, a property that is typically controlled by how the grains are poured or shaken. Here we show that a systematic and controllable increase in granular packing can be induced by simply raising and t...


    pub_type: 杂志文章


    authors: Chen K,Cole J,Conger C,Draskovic J,Lohr M,Klein K,Scheidemantel T,Schiffer P

    更新日期:2006-07-20 00:00:00