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NATURE文献大全abstract::The cloning and characterization of 'clock gene' families has advanced our understanding of the molecular control of the mammalian circadian clock. We have analysed the human genome for additional relatives, and identified new candidate genes that may expand our knowledge of the molecular workings of the circadian clo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35057006
更新日期:2001-02-15 00:00:00
abstract::Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies. Efforts to target this oncogene directly have faced difficulties owing to its picomolar affinity for GTP/GDP and the absence of known alloster...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12796
更新日期:2013-11-28 00:00:00
abstract::The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy. However, the existence of these multipotent MaSCs remains controversial and the nature of such cells is unknown. Here we demonstrate that protein C receptor (Proc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13851
更新日期:2015-01-01 00:00:00
abstract::Vitreoscilla, a filamentous bacterium in the Beggiatoa family, synthesizes a soluble haem-protein which has two identical subunits of relative molecular mass 15,775 and two b haems per molecule. It is synthesized in relatively large quantities when the organism, a strict aerobe, is grown under hypoxic conditions. It f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322481a0
更新日期:1986-07-31 00:00:00
abstract::Collections in early Middle Miocene deposits at Pasalar in Turkey have yielded a very rich fauna. Included in this are two hominoid species referred here to Sivapithecus darwini (Abel) 1902 and Ramapithecus wickeri (Leakey) 1962. These are both more primitive morphologically and earlier in time than other species of t...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/268699a0
更新日期:1977-08-25 00:00:00
abstract::Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) tha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2512-5
更新日期:2020-07-01 00:00:00
abstract::A kinase distinct from the MEK activator Raf, termed MEK kinase-1 (MEKK), was originally identified by virtue of its homology to kinases involved in yeast mating signal cascades. Like Raf, MEKK is capable of activating MEK in vitro. High-level expression of MEKK in COS-7 cells or using vaccinia virus vectors also acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372798a0
更新日期:1994-12-22 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00121-0
更新日期:2019-01-01 00:00:00
abstract::Rimicaris exoculata is a shrimp that swarms over high-temperature (350 degrees C) sulphide chimneys at Mid-Atlantic Ridge hydrothermal fields (3,600 m). This shrimp lacks an externally differentiated eye, having instead a pair of large organs within the cephalothorax immediately beneath the dorsal surface of the trans...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337458a0
更新日期:1989-02-02 00:00:00
abstract::On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12190
更新日期:2013-06-20 00:00:00
abstract::Although the first ten million years of whale evolution are documented by a remarkable series of fossil skeletons, the link to the ancestor of cetaceans has been missing. It was known that whales are related to even-toed ungulates (artiodactyls), but until now no artiodactyls were morphologically close to early whales...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06343
更新日期:2007-12-20 00:00:00
abstract::The known endothelial mitogens stimulate growth of vascular endothelial cells without regard to their tissue of origin. Here we report a growth factor that is expressed largely in one type of tissue and acts selectively on one type of endothelium. This molecule, called endocrine-gland-derived vascular endothelial grow...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35091000
更新日期:2001-08-30 00:00:00
abstract::It has been known for some 50 years that birds use photoreceptors in or near the hypothalamus to mediate the photoperiodic responses that control seasonal breeding. So far, however, attempts to identify the photopigment by determining an action spectrum have failed. The problems stem from the selective filtering of li...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313050a0
更新日期:1985-01-03 00:00:00
abstract::The interaction of lectins with carbohydrate receptors on the plasma membrane of eukaryotic cells results in a wide variety of biological effects. One effect which has been extensively studied is the stimulation of lymphocytes to blastogenesis and proliferation. High doses of concanavalin A (Con A) and phytohaemagglut...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/284273a0
更新日期:1980-03-20 00:00:00
abstract::Tissue-specific transcription factors regulate several important aspects of embryonic development. They must function in the context of DNA assembled into the higher-order structure of chromatin. Enzymatic complexes such as the Swi/Snf-like BAF complexes remodel chromatin to allow the transcriptional machinery access ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03071
更新日期:2004-11-04 00:00:00
abstract::In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22965
更新日期:2017-06-22 00:00:00
abstract::Real-time investigations of the rearrangement of bonds during chemical transformations require femtosecond temporal resolution, so that the atomic vibrations within the reacting molecules can be observed. Following the development of lasers capable of emitting ultrashort laser flashes on this timescale, chemical react...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35107042
更新日期:2001-11-29 00:00:00
abstract::The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07731
更新日期:2009-04-09 00:00:00
abstract::White dwarfs represent the endpoint of stellar evolution for stars with initial masses between approximately 0.07 and 8-10, where is the mass of the Sun (more massive stars end their life as either black holes or neutron stars). The theory of stellar evolution predicts that the majority of white dwarfs have a core mad...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06318
更新日期:2007-11-22 00:00:00
abstract::The long-term exchange of volatile species (such as water, carbon, nitrogen and the noble gases) between deep Earth and surface reservoirs controls the habitability of the Earth's surface. The present-day volatile budget of the mantle reflects the integrated history of outgassing and retention of primordial volatiles ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0388-4
更新日期:2018-08-01 00:00:00
abstract::Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. At the same time, augmentation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/260582a0
更新日期:1976-04-15 00:00:00
abstract::Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282260a0
更新日期:1979-11-15 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07046-0
更新日期:2018-10-01 00:00:00
abstract::Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11513
更新日期:2012-11-01 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are curre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2575-3
更新日期:2020-09-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/37995
更新日期:1997-09-04 00:00:00
abstract::In the response of T cells to foreign antigens, the ligand for the T cell alpha/beta receptor is presented on a cell surface as a fragment of antigen complexed to one of the membrane molecules encoded in the major histocompatibility complex (MHC). The receptor apparently interacts via its variable elements (V beta, D ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332840a0
更新日期:1988-04-28 00:00:00
abstract::During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317449a0
更新日期:1985-10-03 00:00:00
abstract::In this Article, owing to an error during the production process, in Fig. 1a, the dark blue and light blue wedges were incorrectly labelled as 'G•C → T•A' and 'G•C → A•T', instead of 'C•G → T•A' and 'C•G → A•T', respectively. Fig. 1 has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0070-x
更新日期:2018-07-01 00:00:00
abstract::Interstellar dust plays a crucial role in the evolution of the Universe by assisting the formation of molecules, by triggering the formation of the first low-mass stars, and by absorbing stellar ultraviolet-optical light and subsequently re-emitting it at infrared/millimetre wavelengths. Dust is thought to be produced...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02930
更新日期:2004-09-30 00:00:00