Two dynamically distinct circuits drive inhibition in the sensory thalamus.

Abstract:

:Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) that regulate the flow of those data3-6. Although the importance of the TRN has long been recognised7-9, understanding of its cell types, their organization and their functional properties has lagged behind that of the thalamocortical systems they control. Here we address this by investigating the somatosensory and visual circuits of the TRN in mice. In the somatosensory TRN we observed two groups of genetically defined neurons that are topographically segregated and physiologically distinct, and that connect reciprocally with independent thalamocortical nuclei through dynamically divergent synapses. Calbindin-expressing cells-located in the central core-connect with the ventral posterior nucleus, the primary somatosensory thalamocortical relay. By contrast, somatostatin-expressing cells-which reside along the surrounding edges of the TRN-synapse with the posterior medial thalamic nucleus, a higher-order structure that carries both top-down and bottom-up information10-12. The two TRN cell groups process their inputs in pathway-specific ways. Synapses from the ventral posterior nucleus to central TRN cells transmit rapid excitatory currents that depress deeply during repetitive activity, driving phasic spike output. Synapses from the posterior medial thalamic nucleus to edge TRN cells evoke slower, less depressing excitatory currents that drive more persistent spiking. Differences in the intrinsic physiology of TRN cell types, including state-dependent bursting, contribute to these output dynamics. The processing specializations of these two somatosensory TRN subcircuits therefore appear to be tuned to the signals they carry-a primary central subcircuit tuned to discrete sensory events, and a higher-order edge subcircuit tuned to temporally distributed signals integrated from multiple sources. The structure and function of visual TRN subcircuits closely resemble those of the somatosensory TRN. These results provide insights into how subnetworks of TRN neurons may differentially process distinct classes of thalamic information.

journal_name

Nature

journal_title

Nature

authors

Martinez-Garcia RI,Voelcker B,Zaltsman JB,Patrick SL,Stevens TR,Connors BW,Cruikshank SJ

doi

10.1038/s41586-020-2512-5

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

813-818

issue

7818

eissn

0028-0836

issn

1476-4687

pii

10.1038/s41586-020-2512-5

journal_volume

583

pub_type

杂志文章

相关文献

NATURE文献大全
  • Direct thermal neutron detection by the 2D semiconductor 6LiInP2Se6.

    abstract::Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1886-8

    authors: Chica DG,He Y,McCall KM,Chung DY,Pak RO,Trimarchi G,Liu Z,De Lurgio PM,Wessels BW,Kanatzidis MG

    更新日期:2020-01-01 00:00:00

  • Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones.

    abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09058

    authors: Lassance JM,Groot AT,Liénard MA,Antony B,Borgwardt C,Andersson F,Hedenström E,Heckel DG,Löfstedt C

    更新日期:2010-07-22 00:00:00

  • Crystal structure of a nitrate/nitrite exchanger.

    abstract::Mineral nitrogen in nature is often found in the form of nitrate (NO3(-)). Numerous microorganisms evolved to assimilate nitrate and use it as a major source of mineral nitrogen uptake. Nitrate, which is central in nitrogen metabolism, is first reduced to nitrite (NO2(-)) through a two-electron reduction reaction. The...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12139

    authors: Zheng H,Wisedchaisri G,Gonen T

    更新日期:2013-05-30 00:00:00

  • Publisher Correction: The effect of large-scale anti-contagion policies on the COVID-19 pandemic.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41586-020-2691-0

    authors: Hsiang S,Allen D,Annan-Phan S,Bell K,Bolliger I,Chong T,Druckenmiller H,Huang LY,Hultgren A,Krasovich E,Lau P,Lee J,Rolf E,Tseng J,Wu T

    更新日期:2020-09-01 00:00:00

  • Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus.

    abstract::The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism conv...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/287396a0

    authors: Windass JD,Worsey MJ,Pioli EM,Pioli D,Barth PT,Atherton KT,Dart EC,Byrom D,Powell K,Senior PJ

    更新日期:1980-10-02 00:00:00

  • Biodegradation of oil in uplifted basins prevented by deep-burial sterilization.

    abstract::Biodegradation of crude oil by bacterial activity--which has occurred in the majority of the Earth's oil reserves--is known to reduce greatly the quality of petroleum in reservoirs. For economically successful prospecting for oil, it is therefore important to understand the processes and conditions in geological forma...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35082535

    authors: Wilhelms A,Larter SR,Head I,Farrimond P,di-Primio R,Zwach C

    更新日期:2001-06-28 00:00:00

  • Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate.

    abstract::Folding of two monomeric enzymes mediated by groE has been reconstituted in vitro. The groEL protein stabilizes the polypeptides in a conformation resembling the 'molten globule' state. Mg-ATP and groES then promote the acquisition of ordered tertiary structure at the surface of groEL. Folding requires the hydrolysis ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/352036a0

    authors: Martin J,Langer T,Boteva R,Schramel A,Horwich AL,Hartl FU

    更新日期:1991-07-04 00:00:00

  • Palaeontology: pterosaur egg with a leathery shell.

    abstract::The recent discovery of a pterosaur egg with embryonic skeleton and soft tissues from the Yixian Formation confirmed that the flying pterosaurs were oviparous. Here we describe another pterosaur egg whose exquisite preservation indicates that the shell structure was soft and leathery. ...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/432572a

    authors: Ji Q,Ji SA,Cheng YN,You HL,Lü JC,Liu YQ,Yuan CX

    更新日期:2004-12-02 00:00:00

  • Antibody-dependent cell-mediated antibacterial activity of intestinal lymphocytes with secretory IgA.

    abstract::Secretory antibodies of the IgA class (sIgA) are thought to have an important role in the defence against bacteria at mucosal surfaces--the level at which the infectious agents first come into contact with the host. However, the mechanism by which sIgA exert their antibacterial activity is still a matter of debate. Af...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/306184a0

    authors: Tagliabue A,Nencioni L,Villa L,Keren DF,Lowell GH,Boraschi D

    更新日期:1983-11-10 00:00:00

  • Earth's volatile contents established by melting and vaporization.

    abstract::The silicate Earth is strongly depleted in moderately volatile elements (such as lead, zinc, indium and alkali elements) relative to CI chondrites, the meteorites that compositionally most closely resemble the Sun. This depletion may be explained qualitatively by accretion of 10 to 20 per cent of a volatile-rich body ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature23645

    authors: Norris CA,Wood BJ

    更新日期:2017-09-27 00:00:00

  • Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence.

    abstract::Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/318064a0

    authors: Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg V

    更新日期:1985-11-07 00:00:00

  • Human metabolic phenotype diversity and its association with diet and blood pressure.

    abstract::Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. M...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06882

    authors: Holmes E,Loo RL,Stamler J,Bictash M,Yap IK,Chan Q,Ebbels T,De Iorio M,Brown IJ,Veselkov KA,Daviglus ML,Kesteloot H,Ueshima H,Zhao L,Nicholson JK,Elliott P

    更新日期:2008-05-15 00:00:00

  • Control of X chromosome transcription by the maleless gene in Drosophila.

    abstract::In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/285573a0

    authors: Belote JM,Lucchesi JC

    更新日期:1980-06-19 00:00:00

  • Possible presence of high-pressure ice in cold subducting slabs.

    abstract::During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35048555

    authors: Bina CR,Navrotsky A

    更新日期:2000-12-14 00:00:00

  • The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function.

    abstract::Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13498

    authors: Fonseca-Pereira D,Arroz-Madeira S,Rodrigues-Campos M,Barbosa IA,Domingues RG,Bento T,Almeida AR,Ribeiro H,Potocnik AJ,Enomoto H,Veiga-Fernandes H

    更新日期:2014-10-02 00:00:00

  • A rapid mechanism to remobilize and homogenize highly crystalline magma bodies.

    abstract::The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09799

    authors: Burgisser A,Bergantz GW

    更新日期:2011-03-10 00:00:00

  • Nuclear weapons: US research put to vote.

    abstract::A statute banning nuclear weapons research in Cambridge, Massachusetts, is scheduled for a referendum vote in November 1983. If passed, the act would require the city to fine or imprison violators after the ban takes effect in October 1985, and could have an impact on work done at Harvard University and the Massachus...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/305173a0

    authors: David P

    更新日期:1983-09-15 00:00:00

  • Correlation of structural elements and infectivity of the HET-s prion.

    abstract::Prions are believed to be infectious, self-propagating polymers of otherwise soluble, host-encoded proteins. This concept is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in the corresponding hosts...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03793

    authors: Ritter C,Maddelein ML,Siemer AB,Lührs T,Ernst M,Meier BH,Saupe SJ,Riek R

    更新日期:2005-06-09 00:00:00

  • MC4R-dependent suppression of appetite by bone-derived lipocalin 2.

    abstract::Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature21697

    authors: Mosialou I,Shikhel S,Liu JM,Maurizi A,Luo N,He Z,Huang Y,Zong H,Friedman RA,Barasch J,Lanzano P,Deng L,Leibel RL,Rubin M,Nickolas T,Chung W,Zeltser LM,Williams KW,Pessin JE,Kousteni S

    更新日期:2017-03-16 00:00:00

  • Long-term potentiation of electrotonic coupling at mixed synapses.

    abstract::Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/348542a0

    authors: Yang XD,Korn H,Faber DS

    更新日期:1990-12-06 00:00:00

  • Solutions for a cultivated planet.

    abstract::Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10452

    authors: Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

    更新日期:2011-10-12 00:00:00

  • Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

    abstract::A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/305600a0

    authors: Montell C,Fisher EF,Caruthers MH,Berk AJ

    更新日期:1983-10-13 00:00:00

  • Structure of transcribing mammalian RNA polymerase II.

    abstract::RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature16482

    authors: Bernecky C,Herzog F,Baumeister W,Plitzko JM,Cramer P

    更新日期:2016-01-28 00:00:00

  • Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate.

    abstract::Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mechanism, featuring a long-lived oxocarbenium-ion intermediate, was proposed on the basis of model-building studies. The 'Phillips' mechanism is widely held as the paradig...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35090602

    authors: Vocadlo DJ,Davies GJ,Laine R,Withers SG

    更新日期:2001-08-23 00:00:00

  • Identification of proliferative and mature β-cells in the islets of Langerhans.

    abstract::Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature18624

    authors: Bader E,Migliorini A,Gegg M,Moruzzi N,Gerdes J,Roscioni SS,Bakhti M,Brandl E,Irmler M,Beckers J,Aichler M,Feuchtinger A,Leitzinger C,Zischka H,Wang-Sattler R,Jastroch M,Tschöp M,Machicao F,Staiger H,Häring HU,Chme

    更新日期:2016-07-21 00:00:00

  • Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.

    abstract::For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (M...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/386296a0

    authors: Han J,Jiang Y,Li Z,Kravchenko VV,Ulevitch RJ

    更新日期:1997-03-20 00:00:00

  • Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis.

    abstract::The class II region of the human major histocompatibility complex (MHC) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. Each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (Mr) 34,000 (34 K) and a beta-chain of Mr = 28K. The...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/323453a0

    authors: Hardy DA,Bell JI,Long EO,Lindsten T,McDevitt HO

    更新日期:1986-10-02 00:00:00

  • Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors.

    abstract::The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/344068a0

    authors: Havran WL,Allison JP

    更新日期:1990-03-01 00:00:00

  • Mapping GFP structure evolution during proton transfer with femtosecond Raman spectroscopy.

    abstract::Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature08527

    authors: Fang C,Frontiera RR,Tran R,Mathies RA

    更新日期:2009-11-12 00:00:00

  • A synthetic peptide ligase.

    abstract::The preparation of synthetic molecules showing the remarkable efficiencies characteristic of natural biopolymer catalysts remains a formidable challenge for chemical biology. Although significant advances have been made in the understanding of protein structure and function, the de novo construction of such systems re...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/39556

    authors: Severin K,Lee DH,Kennan AJ,Ghadiri MR

    更新日期:1997-10-16 00:00:00