Abstract:
:Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. At the same time, augmentation of noradrenaline vasoconstriction by the released prostaglandin is exaggerated. This biochemical defect could be the inherited abnormality primarily responsible for the development of hypertension in these animals.
journal_name
Naturejournal_title
Natureauthors
Armstrong JM,Blackwell GJ,Flower RJ,McGiff JC,Mullane KM,Vane JRdoi
10.1038/260582a0keywords:
subject
Has Abstractpub_date
1976-04-15 00:00:00pages
582-6issue
5552eissn
0028-0836issn
1476-4687journal_volume
260pub_type
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