From the archive.

abstract：:Water striders Gerridae are insects of characteristic length 1 cm and weight 10 dynes that reside on the surface of ponds, rivers, and the open ocean. Their weight is supported by the surface tension force generated by curvature of the free surface, and they propel themselves by driving their central pair of hydrophob...

journal_title：Nature

authors： Hu DL,Chan B,Bush JW

更新日期：2003-08-07 00:00:00

abstract：:Over 50% of patients who survive neuroinvasive infection with West Nile virus (WNV) exhibit chronic cognitive sequelae. Although thousands of cases of WNV-mediated memory dysfunction accrue annually, the mechanisms responsible for these impairments are unknown. The classical complement cascade, a key component of inna...

journal_title：Nature

authors： Vasek MJ,Garber C,Dorsey D,Durrant DM,Bollman B,Soung A,Yu J,Perez-Torres C,Frouin A,Wilton DK,Funk K,DeMasters BK,Jiang X,Bowen JR,Mennerick S,Robinson JK,Garbow JR,Tyler KL,Suthar MS,Schmidt RE,Stevens B,Klein

更新日期：2016-06-23 00:00:00

abstract：:Optical laser fields have been widely used to achieve quantum control over the motional and internal degrees of freedom of atoms and ions, molecules and atomic gases. A route to controlling the quantum states of macroscopic mechanical oscillators in a similar fashion is to exploit the parametric coupling between optic...

journal_title：Nature

authors： Verhagen E,Deléglise S,Weis S,Schliesser A,Kippenberg TJ

更新日期：2012-02-01 00:00:00

abstract：:Cancer control by adaptive immunity involves a number of defined death and clearance mechanisms. However, efficient inhibition of exponential cancer growth by T cells and interferon-γ (IFN-γ) requires additional undefined mechanisms that arrest cancer cell proliferation. Here we show that the combined action of the T-...

journal_title：Nature

authors： Braumüller H,Wieder T,Brenner E,Aßmann S,Hahn M,Alkhaled M,Schilbach K,Essmann F,Kneilling M,Griessinger C,Ranta F,Ullrich S,Mocikat R,Braungart K,Mehra T,Fehrenbacher B,Berdel J,Niessner H,Meier F,van den Broek M,

更新日期：2013-02-21 00:00:00

abstract：:Contraction of cardiac muscle depends on a transient rise of intracellular calcium concentration ([Ca2+]i) which is initiated by the action potential. It has, however, also been suggested that [Ca2+]i can fluctuate in the absence of changes in membrane potential. The evidence for this is indirect and comes from observ...

journal_title：Nature

authors： Orchard CH,Eisner DA,Allen DG

更新日期：1983-08-25 00:00:00

abstract：:Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...

journal_title：Nature

authors： Goud B,Zahraoui A,Tavitian A,Saraste J

更新日期：1990-06-07 00:00:00

abstract：:Amyloid beta-protein (AP) is a peptide of relative molecular mass (Mr) 42,000 found in the senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients with Alzheimer's disease and Down's syndrome (trisomy 21). Recent molecular genetic evidence has indicated that AP is encoded as part of a...

journal_title：Nature

authors： Tanzi RE,St George-Hyslop PH,Haines JL,Polinsky RJ,Nee L,Foncin JF,Neve RL,McClatchey AI,Conneally PM,Gusella JF

更新日期：1987-09-10 00:00:00

abstract：:The long-term exchange of volatile species (such as water, carbon, nitrogen and the noble gases) between deep Earth and surface reservoirs controls the habitability of the Earth's surface. The present-day volatile budget of the mantle reflects the integrated history of outgassing and retention of primordial volatiles ...

journal_title：Nature

authors： Parai R,Mukhopadhyay S

更新日期：2018-08-01 00:00:00

abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...

journal_title：Nature

authors： DiTullio GR,Grebmeier JM,Arrigo KR,Lizotte MP,Robinson DH,Leventer A,Barry JP,VanWoert ML,Dunbar RB

更新日期：2000-04-06 00:00:00

abstract：:Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specif...

journal_title：Nature

authors： Wagner RW

更新日期：1994-11-24 00:00:00

abstract：:Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and ischaemic disease has unexpected pathophysiological consequences. By uncoupling endothelial cell-cell junctions VEGF causes vascular permea...

journal_title：Nature

authors： Weis SM,Cheresh DA

更新日期：2005-09-22 00:00:00

abstract：:Large mammals, including humans, save much of the energy needed for running by means of elastic structures in their legs and feet. Kinetic and potential energy removed from the body in the first half of the stance phase is stored briefly as elastic strain energy and then returned in the second half by elastic recoil. ...

journal_title：Nature

authors： Ker RF,Bennett MB,Bibby SR,Kester RC,Alexander RM

更新日期：1987-01-08 00:00:00

abstract：:The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...

journal_title：Nature

authors： Leinders-Zufall T,Lane AP,Puche AC,Ma W,Novotny MV,Shipley MT,Zufall F

更新日期：2000-06-15 00:00:00

abstract：:A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. Aft...

journal_title：Nature

authors： Misale S,Yaeger R,Hobor S,Scala E,Janakiraman M,Liska D,Valtorta E,Schiavo R,Buscarino M,Siravegna G,Bencardino K,Cercek A,Chen CT,Veronese S,Zanon C,Sartore-Bianchi A,Gambacorta M,Gallicchio M,Vakiani E,Boscaro V,

更新日期：2012-06-28 00:00:00

abstract：:The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising approximately 1,500 CA protein subunits, which organizes the viral RNA genome for uncoating and replication in a new host cell. In vitro, CA spontaneously assembles into helical tubes and cones that resemble authentic viral capsids. H...

journal_title：Nature

authors： Li S,Hill CP,Sundquist WI,Finch JT

更新日期：2000-09-21 00:00:00

abstract：:DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so far no base-resoluti...

journal_title：Nature

authors： Smith ZD,Chan MM,Mikkelsen TS,Gu H,Gnirke A,Regev A,Meissner A

更新日期：2012-03-28 00:00:00

abstract：:Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolites are extremely rare. The fluoride ion is a potent nucleophile in its desolvated state, but is tightly hydrated in water and effectively inert. Low availability and a la...

journal_title：Nature

authors： Dong C,Huang F,Deng H,Schaffrath C,Spencer JB,O'Hagan D,Naismith JH

更新日期：2004-02-05 00:00:00

abstract：:Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...

journal_title：Nature

authors： King IF,Yandava CN,Mabb AM,Hsiao JS,Huang HS,Pearson BL,Calabrese JM,Starmer J,Parker JS,Magnuson T,Chamberlain SJ,Philpot BD,Zylka MJ

更新日期：2013-09-05 00:00:00

abstract：:Bioluminescent symbioses range from facultative associations to highly adapted, apparently obligate ones. The family Anomalopidae (flashlight fishes) encompasses five genera of tropical reef fishes that have large suborbital light organs. The suborder Ceratioidei (deep-sea anglerfishes) contains 11 families. In nine o...

journal_title：Nature

authors： Haygood MG,Distel DL

更新日期：1993-05-13 00:00:00

abstract：:Metamaterials are artificial optical media composed of sub-wavelength metallic and dielectric building blocks that feature optical phenomena not present in naturally occurring materials. Although they can serve as the basis for unique optical devices that mould the flow of light in unconventional ways, three-dimension...

journal_title：Nature

authors： High AA,Devlin RC,Dibos A,Polking M,Wild DS,Perczel J,de Leon NP,Lukin MD,Park H

更新日期：2015-06-11 00:00:00

abstract：:There is increasing evidence for the process of sympatric speciation, in which reproductive isolation of species occurs without physical isolation. Theoretical models have focused on disruptive natural selection as the crucial pressure for splitting a species. Here we report the theoretical finding that sympatric spec...

journal_title：Nature

authors： Higashi M,Takimoto G,Yamamura N

更新日期：1999-12-02 00:00:00

abstract：:The assessment of changes in tropical cyclone activity within the context of anthropogenically influenced climate change has been limited by the short temporal resolution of the instrumental tropical cyclone record (less than 50 years). Furthermore, controversy exists regarding the robustness of the observational reco...

journal_title：Nature

authors： Haig J,Nott J,Reichart GJ

更新日期：2014-01-30 00:00:00

abstract：:Sensory systems can adapt to the conditions imposed on them. In the visual system, adapting to a pattern increases the threshold of the ability to see that pattern, and reduces the perceived contrast of the pattern above threshold. Most neurons of the striate cortex reduce their responsiveness after being stimulated f...

journal_title：Nature

authors： Snowden RJ,Hammett ST

更新日期：1992-01-16 00:00:00

abstract：:Owing to their scientific and technological importance, inorganic single crystals with highly reactive surfaces have long been studied. Unfortunately, surfaces with high reactivity usually diminish rapidly during the crystal growth process as a result of the minimization of surface energy. A typical example is titaniu...

journal_title：Nature

authors： Yang HG,Sun CH,Qiao SZ,Zou J,Liu G,Smith SC,Cheng HM,Lu GQ

更新日期：2008-05-29 00:00:00

abstract：:In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...

journal_title：Nature

authors： Matsumoto S,Cavadini S,Bunker RD,Grand RS,Potenza A,Rabl J,Yamamoto J,Schenk AD,Schübeler D,Iwai S,Sugasawa K,Kurumizaka H,Thomä NH

更新日期：2019-07-01 00:00:00

abstract：:Auroral substorms, dynamic phenomena that occur in the upper atmosphere at night, are caused by global reconfiguration of the magnetosphere, which releases stored solar wind energy. These storms are characterized by auroral brightening from dusk to midnight, followed by violent motions of distinct auroral arcs that su...

journal_title：Nature

authors： Kasahara S,Miyoshi Y,Yokota S,Mitani T,Kasahara Y,Matsuda S,Kumamoto A,Matsuoka A,Kazama Y,Frey HU,Angelopoulos V,Kurita S,Keika K,Seki K,Shinohara I

更新日期：2018-02-14 00:00:00

abstract：:The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution struct...

journal_title：Nature

authors： Vassylyev DG,Vassylyeva MN,Perederina A,Tahirov TH,Artsimovitch I

更新日期：2007-07-12 00:00:00

abstract：:Heat is fundamental to power generation and many industrial processes, and is most useful at high temperatures because it can be converted more efficiently to other types of energy. However, efficient transportation, storage and conversion of heat at extreme temperatures (more than about 1,300 kelvin) is impractical f...

journal_title：Nature

authors： Amy C,Budenstein D,Bagepalli M,England D,DeAngelis F,Wilk G,Jarrett C,Kelsall C,Hirschey J,Wen H,Chavan A,Gilleland B,Yuan C,Chueh WC,Sandhage KH,Kawajiri Y,Henry A

更新日期：2017-10-11 00:00:00

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:Little is known about virus-host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the alphavirus genus (family Togaviridae), results in lytic infection in most vertebrate cell lines, but persistent productive...

journal_title：Nature

authors： Levine B,Huang Q,Isaacs JT,Reed JC,Griffin DE,Hardwick JM

更新日期：1993-02-25 00:00:00