Ultrasensitive pheromone detection by mammalian vomeronasal neurons.

abstract：:Biodiversity is rapidly declining, and this may negatively affect ecosystem processes, including economically important ecosystem services. Previous studies have shown that biodiversity has positive effects on organisms and processes across trophic levels. However, only a few studies have so far incorporated an explic...

journal_title：Nature

authors： Scherber C,Eisenhauer N,Weisser WW,Schmid B,Voigt W,Fischer M,Schulze ED,Roscher C,Weigelt A,Allan E,Bessler H,Bonkowski M,Buchmann N,Buscot F,Clement LW,Ebeling A,Engels C,Halle S,Kertscher I,Klein AM,Koller R,

更新日期：2010-11-25 00:00:00

abstract：:Helium-neon lasers emitting at 632.8 nm can influence the phytochrome controlled growth and development of plants more than a quarter of a mile away. It may therefore be possible to control the growth of crops using lasers to activate the phytochrome system. ...

journal_title：Nature

authors： Paleg LG,Aspinall D

更新日期：1970-12-05 00:00:00

abstract：:Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples fro...

journal_title：Nature

authors： International HapMap Consortium.

更新日期：2005-10-27 00:00:00

abstract：:The enzyme cytochrome c nitrite reductase catalyses the six-electron reduction of nitrite to ammonia as one of the key steps in the biological nitrogen cycle, where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification. Here we report on the crystal structure of this enzyme from th...

journal_title：Nature

authors： Einsle O,Messerschmidt A,Stach P,Bourenkov GP,Bartunik HD,Huber R,Kroneck PM

更新日期：1999-07-29 00:00:00

abstract：:Werner's syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common. The WS mutation has pleiotropic effects, a...

journal_title：Nature

authors： Goto M,Rubenstein M,Weber J,Woods K,Drayna D

更新日期：1992-02-20 00:00:00

abstract：:Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and a...

journal_title：Nature

authors： Ishikawa F,Miyazono K,Hellman U,Drexler H,Wernstedt C,Hagiwara K,Usuki K,Takaku F,Risau W,Heldin CH

更新日期：1989-04-13 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Molecular processes that govern pathogenic features of erythrocyte invasion and cytoadherence in malaria are reliant on Plasmodium-specific Duffy-binding-like domains (DBLs). These cysteine-rich modules recognize diverse host cell-surface receptors during pathogenesis. DBLs of parasite erythrocyte-binding proteins med...

journal_title：Nature

authors： Singh SK,Hora R,Belrhali H,Chitnis CE,Sharma A

更新日期：2006-02-09 00:00:00

abstract：:Formation of electron pairs is essential to superconductivity. For conventional superconductors, tunnelling spectroscopy has established that pairing is mediated by bosonic modes (phonons); a peak in the second derivative of tunnel current d2I/dV2 corresponds to each phonon mode. For high-transition-temperature (high-...

journal_title：Nature

authors： Lee J,Fujita K,McElroy K,Slezak JA,Wang M,Aiura Y,Bando H,Ishikado M,Masui T,Zhu JX,Balatsky AV,Eisaki H,Uchida S,Davis JC

更新日期：2006-08-03 00:00:00

abstract：:Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could res...

journal_title：Nature

authors： Toth PT,Bindokas VP,Bleakman D,Colmers WF,Miller RJ

更新日期：1993-08-12 00:00:00

abstract：:The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We i...

journal_title：Nature

authors： Elliott LT,Sharp K,Alfaro-Almagro F,Shi S,Miller KL,Douaud G,Marchini J,Smith SM

更新日期：2018-10-01 00:00:00

abstract：:Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult p...

journal_title：Nature

authors： Yamada M,Miyakawa T,Duttaroy A,Yamanaka A,Moriguchi T,Makita R,Ogawa M,Chou CJ,Xia B,Crawley JN,Felder CC,Deng CX,Wess J

更新日期：2001-03-08 00:00:00

abstract：:Rimicaris exoculata is a shrimp that swarms over high-temperature (350 degrees C) sulphide chimneys at Mid-Atlantic Ridge hydrothermal fields (3,600 m). This shrimp lacks an externally differentiated eye, having instead a pair of large organs within the cephalothorax immediately beneath the dorsal surface of the trans...

journal_title：Nature

authors： Van Dover CL,Szuts EZ,Chamberlain SC,Cann JR

更新日期：1989-02-02 00:00:00

abstract：:It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...

journal_title：Nature

authors： Folkard S,Hume KI,Minors DS,Waterhouse JM,Watson FL

更新日期：1985-02-21 00:00:00

abstract：:Some observations suggest that very massive stars experience extreme mass-loss episodes shortly before they explode as supernovae, as do several models. Establishing a causal connection between these mass-loss episodes and the final explosion would provide a novel way to study pre-supernova massive-star evolution. Her...

journal_title：Nature

authors： Ofek EO,Sullivan M,Cenko SB,Kasliwal MM,Gal-Yam A,Kulkarni SR,Arcavi I,Bildsten L,Bloom JS,Horesh A,Howell DA,Filippenko AV,Laher R,Murray D,Nakar E,Nugent PE,Silverman JM,Shaviv NJ,Surace J,Yaron O

更新日期：2013-02-07 00:00:00

abstract：:Complementary DNAs for two distinct anglerfish somatostatin peptides (termed I and II) have been cloned in bacterial plasmids and sequenced. The nucleotide sequence for somatostatin I encodes a large percursor peptide (molecular weight 13,300) in which the somatostatin hormones is at the carboxyl terminus. The predict...

journal_title：Nature

authors： Hobart P,Crawford R,Shen L,Pictet R,Rutter WJ

更新日期：1980-11-13 00:00:00

abstract：:Since the original work on Bose-Einstein condensation1,2, the use of quantum degenerate gases of atoms has enabled the quantum emulation of important systems in condensed matter and nuclear physics, as well as the study of many-body states that have no analogue in other fields of physics3. Ultracold molecules in the m...

journal_title：Nature

authors： Son H,Park JJ,Ketterle W,Jamison AO

更新日期：2020-04-01 00:00:00

abstract：:The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease. Accordingly, neurons invest considerable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain proteostasis an...

journal_title：Nature

authors： Melentijevic I,Toth ML,Arnold ML,Guasp RJ,Harinath G,Nguyen KC,Taub D,Parker JA,Neri C,Gabel CV,Hall DH,Driscoll M

更新日期：2017-02-16 00:00:00

abstract：:A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is co...

journal_title：Nature

authors： Amos LA,Baker TS

更新日期：1979-06-14 00:00:00

abstract：: ...

journal_title：Nature

authors： Witze A

更新日期：2019-03-01 00:00:00

abstract：:Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...

journal_title：Nature

authors： Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba

更新日期：2009-08-13 00:00:00

abstract：:Electronic devices have advanced from their heavy, bulky origins to become smart, mobile appliances. Nevertheless, they remain rigid, which precludes their intimate integration into everyday life. Flexible, textile and stretchable electronics are emerging research areas and may yield mainstream technologies. Rollable ...

journal_title：Nature

authors： Kaltenbrunner M,Sekitani T,Reeder J,Yokota T,Kuribara K,Tokuhara T,Drack M,Schwödiauer R,Graz I,Bauer-Gogonea S,Bauer S,Someya T

更新日期：2013-07-25 00:00:00

abstract：:Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...

journal_title：Nature

authors： Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

更新日期：2015-06-11 00:00:00

abstract：:Blood coagulation can be initiated when factor VII or VIIa, a plasma protease, binds to its essential cofactor, tissue factor (TF), and proteolytically activates factors IX and X, triggering a cascade of events which eventually leads to the formation of thrombin and a fibrin clot. Plasma contains a lipoprotein-associa...

journal_title：Nature

authors： Girard TJ,Warren LA,Novotny WF,Likert KM,Brown SG,Miletich JP,Broze GJ Jr

更新日期：1989-04-06 00:00:00

abstract：:Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...

journal_title：Nature

authors： Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

更新日期：2007-06-21 00:00:00

abstract：:The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This pr...

journal_title：Nature

authors： Goldberg AL

更新日期：2003-12-18 00:00:00

abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

journal_title：Nature

authors： Müller DG,Gassmann G,Lüning K

更新日期：1979-05-31 00:00:00

abstract：:RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...

journal_title：Nature

authors： Galburt EA,Grill SW,Wiedmann A,Lubkowska L,Choy J,Nogales E,Kashlev M,Bustamante C

更新日期：2007-04-12 00:00:00

abstract：:The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods...

journal_title：Nature

authors： Bakken TE,Miller JA,Ding SL,Sunkin SM,Smith KA,Ng L,Szafer A,Dalley RA,Royall JJ,Lemon T,Shapouri S,Aiona K,Arnold J,Bennett JL,Bertagnolli D,Bickley K,Boe A,Brouner K,Butler S,Byrnes E,Caldejon S,Carey A,Cate

更新日期：2016-07-21 00:00:00

abstract：:The formation of glasses is normal for substances that remain liquid over a wide temperature range (the 'good glassformers') and can be induced for most liquids if cooling is fast enough to bypass crystallization. During reheating but still below the melting point, good glassformers exhibit glass transitions as they a...

journal_title：Nature

authors： Yue Y,Angell CA

更新日期：2004-02-19 00:00:00