Abstract:
:Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and ischaemic disease has unexpected pathophysiological consequences. By uncoupling endothelial cell-cell junctions VEGF causes vascular permeability and oedema, resulting in extensive injury to ischaemic tissues after stroke or myocardial infarction. In cancer, VEGF-mediated disruption of the vascular barrier may potentiate tumour cell extravasation, leading to widespread metastatic disease. Therefore, by blocking the vascular permeability promoting effects of VEGF it may be feasible to reduce tissue injury after ischaemic disease and minimize the invasive properties of circulating tumour cells.
journal_name
Naturejournal_title
Natureauthors
Weis SM,Cheresh DAdoi
10.1038/nature03987keywords:
subject
Has Abstractpub_date
2005-09-22 00:00:00pages
497-504issue
7058eissn
0028-0836issn
1476-4687pii
nature03987journal_volume
437pub_type
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