Abstract：
:Mammalian sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis. Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two doses in both males and females, and escape inactivation of the X chromosome in females. Indirect evidence suggests that there must be several pseudoautosomal genes, and several candidates have been proposed. Until now, the only gene that has been unequivocally located in the PAR is MIC2, which encodes a cell-surface antigen of unknown function. We now report the localization of a gene of known function to this region--the gene for the receptor of the haemopoietic regulator, granulocyte-macrophage colony stimulating factor. The chromosomal localization of this gene may be important in understanding the generation of M2 acute myeloid leukaemia.
journal_name
Naturejournal_title
Natureauthors
Gough NM,Gearing DP,Nicola NA,Baker E,Pritchard M,Callen DF,Sutherland GRdoi
10.1038/345734a0subject
Has Abstractpub_date
1990-06-21 00:00:00pages
734-6issue
6277eissn
0028-0836issn
1476-4687journal_volume
345pub_type
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