Electrophoretic movement and localisation of acetylcholine receptors in the embryonic muscle cell membrane.

abstract：:The satellites Rhea and Dione orbit within the magnetosphere of Saturn, where they are exposed to particle irradiation from trapped ions. A similar situation applies to the galilean moons Europa, Ganymede and Callisto, which reside within Jupiter's radiation belts. All of these satellites have surfaces rich in water i...

journal_title：Nature

authors： Noll KS,Roush TL,Cruikshank DP,Johnson RE,Pendleton YJ

更新日期：1997-07-03 00:00:00

abstract：:Cells operate in dynamic environments using extraordinary communication capabilities that emerge from the interactions of genetic circuitry. The mammalian immune response is a striking example of the coordination of different cell types. Cell-to-cell communication is primarily mediated by signalling molecules that for...

journal_title：Nature

authors： Tay S,Hughey JJ,Lee TK,Lipniacki T,Quake SR,Covert MW

更新日期：2010-07-08 00:00:00

abstract：:Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine confers an additio...

journal_title：Nature

authors： Corder R,Douthwaite JA,Lees DM,Khan NQ,Viseu Dos Santos AC,Wood EG,Carrier MJ

更新日期：2001-12-20 00:00:00

abstract：:Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...

journal_title：Nature

authors： Kim D,Lewis DL,Graziadei L,Neer EJ,Bar-Sagi D,Clapham DE

更新日期：1989-02-09 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：:A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods. ...

journal_title：Nature

authors： Seeburg PH,Shine J,Martial JA,Ivarie RD,Morris JA,Ullrich A,Baxter JD,Goodman HM

更新日期：1978-12-21 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00

abstract：:Patterning matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively. In nano...

journal_title：Nature

authors： Alivisatos AP,Johnsson KP,Peng X,Wilson TE,Loweth CJ,Bruchez MP Jr,Schultz PG

更新日期：1996-08-15 00:00:00

abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...

journal_title：Nature

authors： Yuan R,Bickle TA,Ebbers W,Brack C

更新日期：1975-08-14 00:00:00

abstract：:DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...

journal_title：Nature

authors： Dennis EJ,Dobosiewicz M,Jin X,Duvall LB,Hartman PS,Bargmann CI,Vosshall LB

更新日期：2018-10-01 00:00:00

abstract：:The induction of polyarthritis in rats by intradermal immunisation with homologous or heterologous type II collagen incomplete or incomplete Freund's adjuvant was reported recently by Trentham et al. We have now produced a similar disease in certain strains of mice. ...

journal_title：Nature

authors： Courtenay JS,Dallman MJ,Dayan AD,Martin A,Mosedale B

更新日期：1980-02-14 00:00:00

abstract：:A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. Aft...

journal_title：Nature

authors： Misale S,Yaeger R,Hobor S,Scala E,Janakiraman M,Liska D,Valtorta E,Schiavo R,Buscarino M,Siravegna G,Bencardino K,Cercek A,Chen CT,Veronese S,Zanon C,Sartore-Bianchi A,Gambacorta M,Gallicchio M,Vakiani E,Boscaro V,

更新日期：2012-06-28 00:00:00

abstract：:Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see ...

journal_title：Nature

authors： Thilker DA,Donovan J,Schiminovich D,Bianchi L,Boissier S,de Paz AG,Madore BF,Martin DC,Seibert M

更新日期：2009-02-19 00:00:00

abstract：:We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits...

journal_title：Nature

authors： Pesaran B,Nelson MJ,Andersen RA

更新日期：2008-05-15 00:00:00

abstract：:Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...

journal_title：Nature

authors： Leone G,DeGregori J,Sears R,Jakoi L,Nevins JR

更新日期：1997-05-22 00:00:00

abstract：:The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...

journal_title：Nature

authors： Koudelka GB,Harrison SC,Ptashne M

更新日期：1987-04-30 00:00:00

abstract：:Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...

journal_title：Nature

authors： Pakmor R,Kromer M,Röpke FK,Sim SA,Ruiter AJ,Hillebrandt W

更新日期：2010-01-07 00:00:00

abstract：:Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...

journal_title：Nature

authors： Michaloglou C,Vredeveld LC,Soengas MS,Denoyelle C,Kuilman T,van der Horst CM,Majoor DM,Shay JW,Mooi WJ,Peeper DS

更新日期：2005-08-04 00:00:00

abstract：:Because it is so tall, the giraffe, Giraffa camelopardalis, provides an important animal model for investigating adaptive mechanisms to orthostatic (gravitational) pressure changes. Previous physiological studies of the giraffe have concentrated on arterial blood pressures in the heart and neck. Briefly, these investi...

journal_title：Nature

authors： Hargens AR,Millard RW,Pettersson K,Johansen K

更新日期：1987-09-03 00:00:00

abstract：:T lymphocytes of the alpha/beta T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells. In parallel, interactions of the ...

journal_title：Nature

authors： Holländer GA,Wang B,Nichogiannopoulou A,Platenburg PP,van Ewijk W,Burakoff SJ,Gutierrez-Ramos JC,Terhorst C

更新日期：1995-01-26 00:00:00

abstract：:Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + ...

journal_title：Nature

authors： Miick SM,Martinez GV,Fiori WR,Todd AP,Millhauser GL

更新日期：1992-10-15 00:00:00

abstract：:The interrelationships between major living vertebrate, and even chordate, groups are now reasonably well resolved thanks to a large amount of generally congruent data derived from molecular sequences, anatomy and physiology. But fossils provide unexpected combinations of characters that help us to understand how the ...

journal_title：Nature

authors： Janvier P

更新日期：2015-04-23 00:00:00

abstract：:Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in normal bone homeostasis (called 'bone remodelling') but also in the pathogenesis of bone destructive disorders such as rheumatoid arthritis and osteoporosis. A major focus of research in the field ha...

journal_title：Nature

authors： Ishii M,Egen JG,Klauschen F,Meier-Schellersheim M,Saeki Y,Vacher J,Proia RL,Germain RN

更新日期：2009-03-26 00:00:00

abstract：:Developing neurons transiently express somatostatin and its receptors, but little is known about their function at these early stages. As we thought that endogenous somatostatin might control the migratory behaviour of immature neurons, we have examined the effects of somatostatin in cerebellar granule cells of early ...

journal_title：Nature

authors： Yacubova E,Komuro H

更新日期：2002-01-03 00:00:00

abstract：:Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactio...

journal_title：Nature

authors： Ingham PW

更新日期：1988-09-01 00:00:00

abstract：:The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...

journal_title：Nature

authors： Lisiecki LE,Raymo ME,Curry WB

更新日期：2008-11-06 00:00:00

abstract：:Cyclic GMP has been implicated as a messenger molecule involved in visual transduction. Photoexcited rhodopsin (R*) binds to a multisubunit membrane protein called transducin (T) and stimulates the exchange of a bound GDP molecule for GTP. This leads to the release of the alpha-subunit of T with bound GTP (T alpha-GTP...

journal_title：Nature

authors： Vuong TM,Chabre M,Stryer L

更新日期：1984-10-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Glausiusz J

更新日期：2019-01-01 00:00:00

abstract：:The nature and length scales of charge screening in complex oxides are fundamental to a wide range of systems, spanning ceramic voltage-dependent resistors (varistors), oxide tunnel junctions and charge ordering in mixed-valence compounds. There are wide variations in the degree of charge disproportionation, length sc...

journal_title：Nature

authors： Ohtomo A,Muller DA,Grazul JL,Hwang HY

更新日期：2002-09-26 00:00:00

abstract：:alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...

journal_title：Nature

authors： Freeman JA

更新日期：1977-09-15 00:00:00