Abstract：
:We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.
journal_name
Naturejournal_title
Natureauthors
Pesaran B,Nelson MJ,Andersen RAdoi
10.1038/nature06849subject
Has Abstractpub_date
2008-05-15 00:00:00pages
406-9issue
7193eissn
0028-0836issn
1476-4687pii
nature06849journal_volume
453pub_type
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