Abstract:
:First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.
journal_name
Naturejournal_title
Natureauthors
Small EM,Olson ENdoi
10.1038/nature09783subject
Has Abstractpub_date
2011-01-20 00:00:00pages
336-42issue
7330eissn
0028-0836issn
1476-4687pii
nature09783journal_volume
469pub_type
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