Abstract:
:Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Apoptosis comprises an intrinsic cellular defence against tumorigenesis, which, when suppressed, may contribute to the development of malignancies. The bcl-2 oncogene, which is activated in follicular lymphomas, functions as a potent suppressor of apoptosis under diverse conditions. Here we describe the complementary DNA cloning and functional analysis of a new Bcl-2 homologue, Bak, which promotes cell death and counteracts the protection from apoptosis provided by Bcl-2. Moreover, enforced expression of Bak induces rapid and extensive apoptosis of serum-deprived fibroblasts. This raises the possibility that Bak is directly involved in activating the cell death machinery.
journal_name
Naturejournal_title
Natureauthors
Chittenden T,Harrington EA,O'Connor R,Flemington C,Lutz RJ,Evan GI,Guild BCdoi
10.1038/374733a0subject
Has Abstractpub_date
1995-04-20 00:00:00pages
733-6issue
6524eissn
0028-0836issn
1476-4687journal_volume
374pub_type
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