Insulin action impaired by deficiency of the G-protein subunit G ialpha2.


:Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficiency in adipose tissue and liver produces hyperinsulinaemia, impaired glucose tolerance and resistance to insulin in vivo. Insulin resistance affects glucose-transporter activity and recruitment, counterregulation of lipolysis, and activation of glycogen synthase, all of which are cardinal responses to insulin. G ialpha2 deficiency increases protein-tyrosine phosphatase activity and attenuates insulin-stimulated tyrosine phosphorylation of IRS (insulin-receptor substrate 1) in vivo. G ialpha2 deficiency creates a model for insulin resistance characteristic of noninsulin-dependent diabetes mellitus (NIDDM), implicating G ialpha2 as a positive regulator of insulin action.






Moxham CM,Malbon CC




Has Abstract


1996-02-29 00:00:00














  • Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans.

    abstract::Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes that mediate glycosaminoglycan biosynthesis have severe consequences in Drosophila and mice. Mutations in the Drosophila gene sugarless, which ...


    pub_type: 杂志文章


    authors: Mizuguchi S,Uyama T,Kitagawa H,Nomura KH,Dejima K,Gengyo-Ando K,Mitani S,Sugahara K,Nomura K

    更新日期:2003-05-22 00:00:00

  • COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.

    abstract::Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in human prostate cancer. However, the precise mechanism underlying how indolent tumours with PTEN alterations acquire metastatic poten...


    pub_type: 杂志文章


    authors: Qin J,Wu SP,Creighton CJ,Dai F,Xie X,Cheng CM,Frolov A,Ayala G,Lin X,Feng XH,Ittmann MM,Tsai SJ,Tsai MJ,Tsai SY

    更新日期:2013-01-10 00:00:00

  • Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells.

    abstract::Phosphorylation of myosin light chains by a calmodulin-myosin light-chain kinase (MLCK) pathway is considered to be responsible for coupling increased calcium concentration with contraction in smooth muscle. This simple view has, however, recently been questioned. To test this hypothesis directly, we microinjected ind...


    pub_type: 杂志文章


    authors: Itoh T,Ikebe M,Kargacin GJ,Hartshorne DJ,Kemp BE,Fay FS

    更新日期:1989-03-09 00:00:00

  • Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses.

    abstract::The characterization of HIV-1 (HTLV-III/LAV), the human retrovirus associated with AIDS (acquired immune deficiency syndrome) has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus)...


    pub_type: 杂志文章


    authors: Franchini G,Gurgo C,Guo HG,Gallo RC,Collalti E,Fargnoli KA,Hall LF,Wong-Staal F,Reitz MS Jr

    更新日期:1987-08-06 00:00:00

  • Frizzled-7 signalling controls tissue separation during Xenopus gastrulation.

    abstract::Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...


    pub_type: 杂志文章


    authors: Winklbauer R,Medina A,Swain RK,Steinbeisser H

    更新日期:2001-10-25 00:00:00

  • Structural alteration of hair cells in the contralateral ear resulting from extracochlear electrical stimulation.

    abstract::Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...


    pub_type: 杂志文章


    authors: Dodson HC,Walliker JR,Frampton S,Douek EE,Fourcin AJ,Bannister LH

    更新日期:1986-03-06 00:00:00

  • A gravitationally lensed water maser in the early Universe.

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    pub_type: 杂志文章


    authors: Impellizzeri CM,McKean JP,Castangia P,Roy AL,Henkel C,Brunthaler A,Wucknitz O

    更新日期:2008-12-18 00:00:00

  • Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma.

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    pub_type: 杂志文章


    authors: Morse B,Rotherg PG,South VJ,Spandorfer JM,Astrin SM

    更新日期:1988-05-05 00:00:00

  • Re-analysis of radiation-induced specific locus mutations in the mouse.

    abstract::A re-analysis of published data on mouse mutation rates induced by X and gamma rays suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve. We interpret this to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions...


    pub_type: 杂志文章


    authors: Abrahamson S,Wolff S

    更新日期:1976-12-23 00:00:00

  • The Schistosoma japonicum genome reveals features of host-parasite interplay.

    abstract::Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metaz...


    pub_type: 杂志文章


    authors: Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.

    更新日期:2009-07-16 00:00:00

  • Discovery central.

    abstract:: ...


    pub_type: 杂志文章


    authors: Jia H

    更新日期:2018-11-01 00:00:00

  • Plus çà change.

    abstract::For the past couple of centuries the penchant for prediction has been prevalent at century turns. How much have evaluations of scientific discovery and predictions for future advancement changed since those of the science commentators at the end of the last century? ...


    pub_type: 杂志文章


    authors: Heilbron JL,Bynum WF

    更新日期:1999-12-02 00:00:00

  • X-ray kinetic studies of microtubule assembly using synchrotron radiation.

    abstract::The assembly of microtubules has been investigated by time-resolved X-ray diffraction using synchrotron radiation. The small-angle scattering becomes visible within seconds and thus enables study of the structural transitions of the protein aggregates during assembly from their subunits in solution. The X-ray pattern ...


    pub_type: 杂志文章


    authors: Mandelkow EM,Harmsen A,Mandelkow E,Bordas J

    更新日期:1980-10-16 00:00:00

  • Birds have paedomorphic dinosaur skulls.

    abstract::The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of major vertebrate lineages such as mammals, including humans. Birds are the most speciose land verteb...


    pub_type: 杂志文章


    authors: Bhullar BA,Marugán-Lobón J,Racimo F,Bever GS,Rowe TB,Norell MA,Abzhanov A

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  • Initial sequencing and comparative analysis of the mouse genome.

    abstract::The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial com...


    pub_type: 杂志文章


    authors: Mouse Genome Sequencing Consortium.,Waterston RH,Lindblad-Toh K,Birney E,Rogers J,Abril JF,Agarwal P,Agarwala R,Ainscough R,Alexandersson M,An P,Antonarakis SE,Attwood J,Baertsch R,Bailey J,Barlow K,Beck S,Berry E,Bir

    更新日期:2002-12-05 00:00:00

  • Electron-spin domains: magnetic enhancement of superconductivity.

    abstract::An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...


    pub_type: 评论,杂志文章


    authors: Movshovich R,Bianchi A,Capan C,Jaime M,Goodrich RG

    更新日期:2004-02-26 00:00:00

  • Reduced nitrogen fixation in the glacial ocean inferred from changes in marine nitrogen and phosphorus inventories.

    abstract::To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...


    pub_type: 杂志文章


    authors: Ganeshram RS,Pedersen TF,Calvert S,François R

    更新日期:2002-01-10 00:00:00

  • Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.

    abstract::Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type 1 transmembrane domain protein, receptor activity-modifying prote...


    pub_type: 杂志文章


    authors: Liang YL,Khoshouei M,Deganutti G,Glukhova A,Koole C,Peat TS,Radjainia M,Plitzko JM,Baumeister W,Miller LJ,Hay DL,Christopoulos A,Reynolds CA,Wootten D,Sexton PM

    更新日期:2018-09-01 00:00:00

  • The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

    abstract::A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant ch...


    pub_type: 杂志文章


    authors: Ghosh P,Amaya M,Mellins E,Wiley DC

    更新日期:1995-11-30 00:00:00

  • Compositional homogeneity in the fragmented comet 73P/Schwassmann-Wachmann 3.

    abstract::The remarkable compositional diversity of volatile ices within comets can plausibly be attributed to several factors, including differences in the chemical, thermal and radiation environments in comet-forming regions, chemical evolution during their long storage in reservoirs far from the Sun, and thermal processing b...


    pub_type: 杂志文章


    authors: Dello Russo N,Vervack RJ,Weaver HA,Biver N,Bockelée-Morvan D,Crovisier J,Lisse CM

    更新日期:2007-07-12 00:00:00

  • Reactivity of HTLV-transformed human T-cell lines to MHC class II antigens.

    abstract::T-cell lines established from individuals infected with human T-cell leukaemia virus (HTLV) or generated by co-cultivation of normal human T cells with HTLV-infected T-cells, express class II (HLA-D/DR or Ia) antigens of the major histocompatibility complex (MHC) and interleukin-2 (IL-2) receptors. Because the express...


    pub_type: 杂志文章


    authors: Suciu-Foca N,Rubinstein P,Popovic M,Gallo RC,King DW

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  • Evolution of a central neural circuit underlies Drosophila mate preferences.

    abstract::Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...


    pub_type: 杂志文章


    authors: Seeholzer LF,Seppo M,Stern DL,Ruta V

    更新日期:2018-07-01 00:00:00

  • Rapid worldwide depletion of predatory fish communities.

    abstract::Serious concerns have been raised about the ecological effects of industrialized fishing, spurring a United Nations resolution on restoring fisheries and marine ecosystems to healthy levels. However, a prerequisite for restoration is a general understanding of the composition and abundance of unexploited fish communit...


    pub_type: 杂志文章,meta分析


    authors: Myers RA,Worm B

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  • Sequencing the nuclear genome of the extinct woolly mammoth.

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    pub_type: 杂志文章


    authors: Miller W,Drautz DI,Ratan A,Pusey B,Qi J,Lesk AM,Tomsho LP,Packard MD,Zhao F,Sher A,Tikhonov A,Raney B,Patterson N,Lindblad-Toh K,Lander ES,Knight JR,Irzyk GP,Fredrikson KM,Harkins TT,Sheridan S,Pringle T,Schuste

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  • Evidence for grid cells in a human memory network.

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    pub_type: 杂志文章


    authors: Doeller CF,Barry C,Burgess N

    更新日期:2010-02-04 00:00:00

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    pub_type: 杂志文章


    authors: Pearse AM,Swift K

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    pub_type: 杂志文章


    authors: Wrana JL,Attisano L,Wieser R,Ventura F,Massagué J

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  • Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein.

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    pub_type: 杂志文章


    authors: Feramisco JR,Clark R,Wong G,Arnheim N,Milley R,McCormick F

    更新日期:1985-04-18 00:00:00

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    pub_type: 杂志文章


    authors: Jazayeri A,Doré AS,Lamb D,Krishnamurthy H,Southall SM,Baig AH,Bortolato A,Koglin M,Robertson NJ,Errey JC,Andrews SP,Teobald I,Brown AJ,Cooke RM,Weir M,Marshall FH

    更新日期:2016-05-12 00:00:00

  • Bell violation using entangled photons without the fair-sampling assumption.

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    pub_type: 杂志文章


    authors: Giustina M,Mech A,Ramelow S,Wittmann B,Kofler J,Beyer J,Lita A,Calkins B,Gerrits T,Nam SW,Ursin R,Zeilinger A

    更新日期:2013-05-09 00:00:00