Abstract：
:The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact have only recently become apparent.
journal_name
Naturejournal_title
Natureauthors
Clark EA,Ledbetter JAdoi
10.1038/367425a0subject
Has Abstractpub_date
1994-02-03 00:00:00pages
425-8issue
6462eissn
0028-0836issn
1476-4687journal_volume
367pub_type
杂志文章,评审相关文献
NATURE文献大全abstract：:Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactio...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/335025a0
更新日期：1988-09-01 00:00:00
abstract：:The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature02872
更新日期：2004-09-16 00:00:00
abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2477-4
更新日期：2020-07-01 00:00:00
abstract：:It has been known for some 50 years that birds use photoreceptors in or near the hypothalamus to mediate the photoperiodic responses that control seasonal breeding. So far, however, attempts to identify the photopigment by determining an action spectrum have failed. The problems stem from the selective filtering of li...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/313050a0
更新日期：1985-01-03 00:00:00
abstract：:The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NA...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/314592a0
更新日期：1985-04-18 00:00:00
abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...
journal_title：Nature
pub_type： 杂志文章,收录出版
doi：10.1038/nature12594
更新日期：2013-10-24 00:00:00
abstract：:Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various cancers. Commo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09745
更新日期：2011-02-03 00:00:00
abstract：:Galaxies had their most significant impact on the Universe when they assembled their first generations of stars. Energetic photons emitted by young, massive stars in primeval galaxies ionized the intergalactic medium surrounding their host galaxies, cleared sightlines along which the light of the young galaxies could ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09462
更新日期：2010-10-21 00:00:00
abstract：:During cell division, remodelling of the nuclear envelope enables chromosome segregation by the mitotic spindle1. The reformation of sealed nuclei requires ESCRTs (endosomal sorting complexes required for transport) and LEM2, a transmembrane ESCRT adaptor2-4. Here we show how the ability of LEM2 to condense on microtu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2232-x
更新日期：2020-06-01 00:00:00
abstract：:In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting it...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/332509a0
更新日期：1988-04-07 00:00:00
abstract：:The first nerve cells to appear in the limb buds of embryonic grasshoppers are a pair which lie at the distal tip and project axons along the length of the limb to the central nervous system (CNS). The stereotyped route navigated by these 'pioneer' axons is followed by other neurones and eventually becomes that of a m...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/304062a0
更新日期：1983-07-07 00:00:00
abstract：:Gut microbes supply the human body with energy from dietary polysaccharides through carbohydrate active enzymes, or CAZymes, which are absent in the human genome. These enzymes target polysaccharides from terrestrial plants that dominated diet throughout human evolution. The array of CAZymes in gut microbes is highly ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08937
更新日期：2010-04-08 00:00:00
abstract：:Cell surface molecules have been implicated in cell interactions which underlie formation of the nervous system. The analysis of the functional properties of such molecules has profited from the combined use of antibodies and cell culture systems. It has been suggested that the interplay between these molecules modula...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/311153a0
更新日期：1984-09-13 00:00:00
abstract：:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature06175
更新日期：2007-09-27 00:00:00
abstract：:DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron microscopy, we report...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14685
更新日期：2015-08-13 00:00:00
abstract：:53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0362-1
更新日期：2018-08-01 00:00:00
abstract：:Sheep learn to recognize the odours of their lambs within two hours of giving birth, and this learning involves synaptic changes within the olfactory bulb. Specifically, mitral cells become increasingly responsive to the learned odour, which stimulates release of both glutamate and GABA (gamma-aminobutyric acid) neuro...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/41765
更新日期：1997-08-14 00:00:00
abstract：:The upright posture and obligatory bipedalism of modern humans are unique among living primates. The evolutionary history of this behaviour has traditionally been pursued by functional analysis of the postcranial skeleton and the preserved footprint trails of fossil hominids. Here we report a systematic attempt to rec...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/369645a0
更新日期：1994-06-23 00:00:00
abstract：:Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06210
更新日期：2007-10-04 00:00:00
abstract：:A brief account is provided of a meeting between federal officials and representatives of the Industrial Biotechnology Association (IBA), a consortium of companies concerned about the regulatory outlook for their industry. Current regulatory interest is focused on the Environmental Protection Agency, which has declar...
journal_title：Nature
pub_type： 新闻
doi：10.1038/305755a0
更新日期：1983-10-27 00:00:00
abstract：:Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid eli...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/387188a0
更新日期：1997-05-08 00:00:00
abstract：:Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/21202
更新日期：1999-06-10 00:00:00
abstract：:Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and prevents chronic inflammation and autoimmune pathologies. The diverse array of phagocytes that reside within different tissues, combined with the necessarily prompt natu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20138
更新日期：2016-11-24 00:00:00
abstract：:The theory of electric polarization in crystals defines the dipole moment of an insulator in terms of a Berry phase (geometric phase) associated with its electronic ground state. This concept not only solves the long-standing puzzle of how to calculate dipole moments in crystals, but also explains topological band str...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25777
更新日期：2018-03-14 00:00:00
abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1162-y
更新日期：2019-05-01 00:00:00
abstract：:p60src, the transforming protein of Rous sarcoma virus (RSV), is a protein kinase that has a strict specificity for tyrosine. The phosphorylation of cellular proteins by p60src (ref. 4) results in transformation. Recently, Barker and Dayhoff discovered that residues 259-485 of p60src have 22% sequence identity with re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310589a0
更新日期：1984-08-16 00:00:00
abstract：:The src gene product, p60src, of Rous sarcoma virus (RSV) is a tyrosine-specific protein kinase which is associated with the plasma membrane of infected cells. Myristic acid is bound in an amide linkage to glycine 2 of p60src. Of the N-terminal 30 kilodaltons of p60src, only amino acids 1-14 are required for myristyla...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/314374a0
更新日期：1985-03-28 00:00:00
abstract：:Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie phenotypic variation. Moreover, wild strains of the plant Arabidopsis thaliana differ in many epialleles, and these can influence the expression of nearby genes. However, to understand their role in evolution, it is imperative ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10555
更新日期：2011-09-20 00:00:00
abstract：:The availability of methods for the amplification of nucleic acid sequences allows the genetic analysis in vitro of the structural and functional properties of many nucleic acids. We have now developed an in vitro selection and amplification system, and used it to analyse the self-splicing Tetrahymena ribozyme. A much...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/347406a0
更新日期：1990-09-27 00:00:00
abstract：:Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04672
更新日期：2006-04-27 00:00:00
