Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

Abstract:

:The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NADH-K3Fe(CN)6 oxidoreductase activities. We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase.

journal_name

Nature

journal_title

Nature

authors

Chomyn A,Mariottini P,Cleeter MW,Ragan CI,Matsuno-Yagi A,Hatefi Y,Doolittle RF,Attardi G

doi

10.1038/314592a0

subject

Has Abstract

pub_date

1985-04-18 00:00:00

pages

592-7

issue

6012

eissn

0028-0836

issn

1476-4687

journal_volume

314

pub_type

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