A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe.

abstract：:The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromos...

journal_title：Nature

authors： Bodmer M,Ashburner M

更新日期：1984-05-31 00:00:00

abstract：:An essential feature of the bacterial pathogen Salmonella spp. is its ability to enter cells that are normally non-phagocytic, such as those of the intestinal epithelium. The bacterium achieves entry by delivering effector proteins into the host-cell cytosol by means of a specialized protein-secretion system (termed t...

journal_title：Nature

authors： Fu Y,Galán JE

更新日期：1999-09-16 00:00:00

abstract：:The receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction. Igf2/Mpr has been mapped to the mouse Tme locus and shown to be an imprinte...

journal_title：Nature

authors： Wang ZQ,Fung MR,Barlow DP,Wagner EF

更新日期：1994-12-01 00:00:00

abstract：:Adsorption-based phenomena are important in gas separations, such as the treatment of greenhouse-gas and toxic-gas pollutants, and in water-adsorption-based heat pumps for solar cooling systems. The ability to tune the pore size, shape and functionality of crystalline porous coordination polymers--or metal-organic fra...

journal_title：Nature

authors： Krause S,Bon V,Senkovska I,Stoeck U,Wallacher D,Többens DM,Zander S,Pillai RS,Maurin G,Coudert FX,Kaskel S

更新日期：2016-04-21 00:00:00

abstract：:The first event in the initiation of an immune response is the capture and presentation of antigen to T cells. Such presentation involves two distinct steps: (1) display of the antigen, which requires uptake, processing and re-expression of the antigen in association with MHC molecules on the presenting cell surface; ...

journal_title：Nature

authors： Lassila O,Vainio O,Matzinger P

更新日期：1988-07-21 00:00:00

abstract：:Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. This results in the nuclear translocation of freed NF-kappaB dimers and the activation...

journal_title：Nature

authors： Rothwarf DM,Zandi E,Natoli G,Karin M

更新日期：1998-09-17 00:00:00

abstract：:The refined 1.9-A resolution structure of the periplasmic D-galactose-binding protein (GBP) reveals a calcium ion surrounded by seven ligands, all protein oxygen atoms. A nine-residue loop (amino-acid positions 134-142), which is preceded by a beta-turn and followed by a beta-strand, provides five ligands from every s...

journal_title：Nature

authors： Vyas NK,Vyas MN,Quiocho FA

更新日期：1987-06-18 00:00:00

abstract：:Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its mai...

journal_title：Nature

authors： Scita G,Di Fiore PP

更新日期：2010-01-28 00:00:00

abstract：:Seventeen hominoid fossils recovered from Pliocene strata at Aramis, Middle Awash, Ethiopia make up a series comprising dental, cranial and postcranial specimens dated to around 4.4 million years ago. When compared with Australopithecus afarensis and with modern and fossil apes the Aramis fossil hominids are recognize...

journal_title：Nature

authors： White TD,Suwa G,Asfaw B

更新日期：1994-09-22 00:00:00

abstract：:Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nit...

journal_title：Nature

authors： Stüeken EE,Buick R,Guy BM,Koehler MC

更新日期：2015-04-30 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis an...

journal_title：Nature

authors： Herndon LA,Schmeissner PJ,Dudaronek JM,Brown PA,Listner KM,Sakano Y,Paupard MC,Hall DH,Driscoll M

更新日期：2002-10-24 00:00:00

abstract：:Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...

journal_title：Nature

authors： Marlovits TC,Kubori T,Lara-Tejero M,Thomas D,Unger VM,Galán JE

更新日期：2006-06-01 00:00:00

abstract：:Protonic ceramic fuel cells, like their higher-temperature solid-oxide fuel cell counterparts, can directly use both hydrogen and hydrocarbon fuels to produce electricity at potentially more than 50 per cent efficiency1,2. Most previous direct-hydrocarbon fuel cell research has focused on solid-oxide fuel cells based ...

journal_title：Nature

authors： Duan C,Kee RJ,Zhu H,Karakaya C,Chen Y,Ricote S,Jarry A,Crumlin EJ,Hook D,Braun R,Sullivan NP,O'Hayre R

更新日期：2018-05-01 00:00:00

abstract：:Understanding how ecological communities are organized and how they change through time is critical to predicting the effects of climate change. Recent work documenting the co-occurrence structure of modern communities found that most significant species pairs co-occur less frequently than would be expected by chance....

journal_title：Nature

authors： Lyons SK,Amatangelo KL,Behrensmeyer AK,Bercovici A,Blois JL,Davis M,DiMichele WA,Du A,Eronen JT,Faith JT,Graves GR,Jud N,Labandeira C,Looy CV,McGill B,Miller JH,Patterson D,Pineda-Munoz S,Potts R,Riddle B,Terry R

更新日期：2016-01-07 00:00:00

abstract：:Perfusion chromatography is a technique based on fluid dynamics for reducing stagnant mobile phase mass transfer in liquid chromatography. This is achieved by using supports with large pores that allow mobile phase to flow through particles. ...

journal_title：Nature

authors： Regnier FE

更新日期：1991-04-18 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00

abstract：:Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM cells generated by viral infection of the skin differentially ex...

journal_title：Nature

authors： Pan Y,Tian T,Park CO,Lofftus SY,Mei S,Liu X,Luo C,O'Malley JT,Gehad A,Teague JE,Divito SJ,Fuhlbrigge R,Puigserver P,Krueger JG,Hotamisligil GS,Clark RA,Kupper TS

更新日期：2017-03-09 00:00:00

abstract：:Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...

journal_title：Nature

authors： Roy K,Jaiswal A,Panda P

更新日期：2019-11-01 00:00:00

abstract：:The structure of water near non-polar molecular fragments or surfaces mediates the hydrophobic interactions that underlie a broad range of interfacial, colloidal and biophysical phenomena. Substantial progress over the past decade has improved our understanding of hydrophobic interactions in simple model systems, but ...

journal_title：Nature

authors： Ma CD,Wang C,Acevedo-Vélez C,Gellman SH,Abbott NL

更新日期：2015-01-15 00:00:00

abstract：:Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. For example, despite intensive investigations over half a century, the neuronal implementation of local motion detection in t...

journal_title：Nature

authors： Takemura SY,Bharioke A,Lu Z,Nern A,Vitaladevuni S,Rivlin PK,Katz WT,Olbris DJ,Plaza SM,Winston P,Zhao T,Horne JA,Fetter RD,Takemura S,Blazek K,Chang LA,Ogundeyi O,Saunders MA,Shapiro V,Sigmund C,Rubin GM,Scheffe

更新日期：2013-08-08 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:What is it that defines an animal? The definition provided here, made on the basis of developmental biology, suggests methods for resolving phylogenetic problems. ...

journal_title：Nature

authors： Slack JM,Holland PW,Graham CF

更新日期：1993-02-11 00:00:00

abstract：:Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades. Here we show that human JAK2 is present in the nucleus o...

journal_title：Nature

authors： Dawson MA,Bannister AJ,Göttgens B,Foster SD,Bartke T,Green AR,Kouzarides T

更新日期：2009-10-08 00:00:00

abstract：:How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentifie...

journal_title：Nature

authors： Biondi EG,Reisinger SJ,Skerker JM,Arif M,Perchuk BS,Ryan KR,Laub MT

更新日期：2006-12-14 00:00:00

abstract：:The RNA polymerase II large subunit contains an essential carboxy-terminal domain (CTD) believed to be involved in the response to regulators during transcription initiation. The CTD is phosphorylated on a portion of RNA polymerase II molecules in vivo and it can be phosphorylated by the general transcription factor T...

journal_title：Nature

authors： Serizawa H,Mäkelä TP,Conaway JW,Conaway RC,Weinberg RA,Young RA

更新日期：1995-03-16 00:00:00

abstract：:The difficulty of working with the intact brain in vivo has led to the increasing use of nerve cell cultures in neurobiology. However, dissociated cells cannot be unambiguously identified by morphological criteria before the third week in culture, for it is not until then that the basic morphology and size of neurones...

journal_title：Nature

authors： Hooghe-Peters EL,Fowlkes BJ,Hooghe RJ

更新日期：1979-10-04 00:00:00

abstract：:Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...

journal_title：Nature

authors： Wainger BJ,DeGennaro M,Santoro B,Siegelbaum SA,Tibbs GR

更新日期：2001-06-14 00:00:00

abstract：:The three-dimensional structure of the 67K amino-terminal fragment of Escherichia coli DNA topoisomerase I has been determined to 2.2 A resolution. The polypeptide folds in an unusual way to give four distinct domains enclosing a hole large enough to accommodate a double-stranded DNA. The active-site tyrosyl residue, ...

journal_title：Nature

authors： Lima CD,Wang JC,Mondragón A

更新日期：1994-01-13 00:00:00

abstract：:Self-assembled polyhedral structures are common in biology. The coats of many viruses, for example, have a structure based on icosahedral symmetry. The preparation of synthetic polyhedral molecular assemblies represents a challenging problem, but supramolecular chemistry has now advanced to the point where the task ma...

journal_title：Nature

authors： Olenyuk B,Whiteford JA,Fechtenkötter A,Stang PJ

更新日期：1999-04-29 00:00:00