Modulation of hydrophobic interactions by proximally immobilized ions.

abstract：:The genes for the T-cell receptor, like the immunoglobulin genes, are rearranged as DNA. The mechanism of this rearrangement is not clear; unequal crossover between chromosomes and the looping-out and excision of the excess DNA have both been suggested. We isolated small polydisperse circular (spc) DNAs from mouse thy...

journal_title：Nature

authors： Fujimoto S,Yamagishi H

更新日期：1987-05-21 00:00:00

abstract：:Nanoscale or colloidal particles are important in many realms of science and technology. They can dramatically change the properties of materials, imparting solid-like behaviour to a wide variety of complex fluids. This behaviour arises when particles aggregate to form mesoscopic clusters and networks. The essential c...

journal_title：Nature

authors： Lu PJ,Zaccarelli E,Ciulla F,Schofield AB,Sciortino F,Weitz DA

更新日期：2008-05-22 00:00:00

abstract：:Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...

journal_title：Nature

authors： Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

更新日期：2007-06-21 00:00:00

abstract：:Self-incompatibility in flowering plants is often controlled by a single nuclear gene (the S-gene) having several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S-alleles expressed in the style. Sequence analysis shows that three alleles of the S gene of Nicotiana alata...

journal_title：Nature

authors： McClure BA,Haring V,Ebert PR,Anderson MA,Simpson RJ,Sakiyama F,Clarke AE

更新日期：1989-12-21 00:00:00

abstract：:Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and negative regulators antagonistic to alternate fates often act in conjunction with positive regula...

journal_title：Nature

authors： Roychoudhuri R,Hirahara K,Mousavi K,Clever D,Klebanoff CA,Bonelli M,Sciumè G,Zare H,Vahedi G,Dema B,Yu Z,Liu H,Takahashi H,Rao M,Muranski P,Crompton JG,Punkosdy G,Bedognetti D,Wang E,Hoffmann V,Rivera J,Marincol

更新日期：2013-06-27 00:00:00

abstract：:Electric-field-induced charge separation (polarization) is the most fundamental manifestation of the interaction of light with matter and a phenomenon of great technological relevance. Nonlinear optical polarization produces coherent radiation in spectral ranges inaccessible by lasers and constitutes the key to ultima...

journal_title：Nature

authors： Sommer A,Bothschafter EM,Sato SA,Jakubeit C,Latka T,Razskazovskaya O,Fattahi H,Jobst M,Schweinberger W,Shirvanyan V,Yakovlev VS,Kienberger R,Yabana K,Karpowicz N,Schultze M,Krausz F

更新日期：2016-06-02 00:00:00

abstract：:An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...

journal_title：Nature

authors： Movshovich R,Bianchi A,Capan C,Jaime M,Goodrich RG

更新日期：2004-02-26 00:00:00

abstract：:The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising approximately 1,500 CA protein subunits, which organizes the viral RNA genome for uncoating and replication in a new host cell. In vitro, CA spontaneously assembles into helical tubes and cones that resemble authentic viral capsids. H...

journal_title：Nature

authors： Li S,Hill CP,Sundquist WI,Finch JT

更新日期：2000-09-21 00:00:00

abstract：:Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control lifespan. Here we show that the hypothalamus is important for the development of whole-body ageing in mice, and that the un...

journal_title：Nature

authors： Zhang G,Li J,Purkayastha S,Tang Y,Zhang H,Yin Y,Li B,Liu G,Cai D

更新日期：2013-05-09 00:00:00

abstract：:Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-l...

journal_title：Nature

authors： Soda M,Choi YL,Enomoto M,Takada S,Yamashita Y,Ishikawa S,Fujiwara S,Watanabe H,Kurashina K,Hatanaka H,Bando M,Ohno S,Ishikawa Y,Aburatani H,Niki T,Sohara Y,Sugiyama Y,Mano H

更新日期：2007-08-02 00:00:00

abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....

journal_title：Nature

authors： Tsai WW,Wang Z,Yiu TT,Akdemir KC,Xia W,Winter S,Tsai CY,Shi X,Schwarzer D,Plunkett W,Aronow B,Gozani O,Fischle W,Hung MC,Patel DJ,Barton MC

更新日期：2010-12-16 00:00:00

abstract：:To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...

journal_title：Nature

authors： Beck JR,Muralidharan V,Oksman A,Goldberg DE

更新日期：2014-07-31 00:00:00

abstract：: ...

journal_title：Nature

authors： Hills R,Kulkarni G,Meerburg PD,Puchwein E

更新日期：2018-12-01 00:00:00

abstract：:There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularly controversial. Although there are some well-characterized examples, most (>95%) show little evidence of evolutionary conservation and...

journal_title：Nature

authors： Guttman M,Amit I,Garber M,French C,Lin MF,Feldser D,Huarte M,Zuk O,Carey BW,Cassady JP,Cabili MN,Jaenisch R,Mikkelsen TS,Jacks T,Hacohen N,Bernstein BE,Kellis M,Regev A,Rinn JL,Lander ES

更新日期：2009-03-12 00:00:00

abstract：:Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...

journal_title：Nature

authors： Galonić DP,Gin DY

更新日期：2007-04-26 00:00:00

abstract：:In contrast to double-stranded DNA, there has so far been little evidence that double-stranded RNA can undergo major conformational transitions. We have investigated the conformation in different conditions of the double-stranded RNA molecule poly(G-C).poly(G-C), by NMR, circular dichroism and absorbance spectroscopy....

journal_title：Nature

authors： Hall K,Cruz P,Tinoco I Jr,Jovin TM,van de Sande JH

更新日期：1984-10-11 00:00:00

abstract：:In somatic cells, entry into mitosis depends on the completion of DNA synthesis. This dependency is established by S-phase feedback controls that arrest cell division when damaged or unreplicated DNA is present. In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosi...

journal_title：Nature

authors： Sorger PK,Murray AW

更新日期：1992-01-23 00:00:00

abstract：:Lymphocyte function-associated antigen-1 (LFA-1) is a heterodimer composed of an alpha and beta chain that is expressed on the surface of most leukocytes and is an essential molecule for adhesion reactions between cells participating in the immune response. A putative ligand for LFA-1 is the intercellular adhesion mol...

journal_title：Nature

authors： van Noesel C,Miedema F,Brouwer M,de Rie MA,Aarden LA,van Lier RA

更新日期：1988-06-30 00:00:00

abstract：:The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leuk...

journal_title：Nature

authors： Mullighan CG,Miller CB,Radtke I,Phillips LA,Dalton J,Ma J,White D,Hughes TP,Le Beau MM,Pui CH,Relling MV,Shurtleff SA,Downing JR

更新日期：2008-05-01 00:00:00

abstract：:Triton is Neptune's principal satellite and is by far the largest retrograde satellite in the Solar System (its mass is approximately 40 per cent greater than that of Pluto). Its inclined and circular orbit lies between a group of small inner prograde satellites and a number of exterior irregular satellites with both ...

journal_title：Nature

authors： Agnor CB,Hamilton DP

更新日期：2006-05-11 00:00:00

abstract：:Endocytosis of the major histocompatibility complex (MHC)-encoded class I and class II molecules has been the subject of recent investigations. Class I molecules, which are key elements in T cell-mediated cytotoxicity, are differentially endocytosed by different cell types. Fibroblasts internalize their class I molecu...

journal_title：Nature

authors： Machy P,Truneh A,Gennaro D,Hoffstein S

更新日期：1987-08-20 00:00:00

abstract：:At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...

journal_title：Nature

authors： Turecek J,Jackman SL,Regehr WG

更新日期：2017-11-23 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:Experimental and simulation studies show that small monomeric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends ...

journal_title：Nature

authors： Shakhnovich E,Abkevich V,Ptitsyn O

更新日期：1996-01-04 00:00:00

abstract：:During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle. In the spindle, kinetochore microtubules have their plus ends embedded in the kinetochore and their minus ends at the spindle pole. Two models have been proposed to account for the movement of chromatids during...

journal_title：Nature

authors： Rogers GC,Rogers SL,Schwimmer TA,Ems-McClung SC,Walczak CE,Vale RD,Scholey JM,Sharp DJ

更新日期：2004-01-22 00:00:00

abstract：:The holotype of Deinocheirus mirificus was collected by the 1965 Polish-Mongolian Palaeontological Expedition at Altan Uul III in the southern Gobi of Mongolia. Because the holotype consists mostly of giant forelimbs (2.4 m in length) with scapulocoracoids, for almost 50 years Deinocheirus has remained one of the most...

journal_title：Nature

authors： Lee YN,Barsbold R,Currie PJ,Kobayashi Y,Lee HJ,Godefroit P,Escuillié F,Chinzorig T

更新日期：2014-11-13 00:00:00

abstract：:The double helix of DNA epitomizes this molecule's ability to self-assemble in aqueous solutions into a complex chiral structure using hydrogen bonding and hydrophobic interactions. Non-covalently interacting molecules in organic solvents are used to design systems that similarly form controlled architectures. Periphe...

journal_title：Nature

authors： Hirschberg JH,Brunsveld L,Ramzi A,Vekemans JA,Sijbesma RP,Meijer EW

更新日期：2000-09-14 00:00:00

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:Regulation of messenger RNA translation is central to eukaryotic gene expression control. Regulatory inputs are specified by them RNA untranslated regions (UTRs) and often target translation initiation. Initiation involves binding of the 40S ribosomal small subunit (SSU) and associated eukaryotic initiation factors (e...

journal_title：Nature

authors： Archer SK,Shirokikh NE,Beilharz TH,Preiss T

更新日期：2016-07-28 00:00:00

abstract：:It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...

journal_title：Nature

authors： Rose KM,Bell LE,Jacob ST

更新日期：1977-05-12 00:00:00