Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes.

Abstract:

:Endocytosis of the major histocompatibility complex (MHC)-encoded class I and class II molecules has been the subject of recent investigations. Class I molecules, which are key elements in T cell-mediated cytotoxicity, are differentially endocytosed by different cell types. Fibroblasts internalize their class I molecules via uncoated cell surface vesicles and tubular invaginations when these molecules are cross-linked with multivalent ligands. T lymphocytes internalize their class I molecules spontaneously, but B lymphocytes do not internalize them at all. Here we describe a morphological investigation of the mechanism by which class I molecules are endocytosed by T lymphocytes. We show that, unlike fibroblasts, T lymphocytes spontaneously internalize 20-40% of their class I molecules in a process involving coated pits and coated vesicles. Thus, the endocytic pathway of class I molecules in T lymphocytes is similar to those of other more classical cell-surface receptors involved in receptor-mediated endocytosis. In contrast, the same class I molecules remained on the cell surface in B lymphocytes. These data show that class I molecules are differentially regulated in T and B lymphocytes and fibroblasts.

journal_name

Nature

journal_title

Nature

authors

Machy P,Truneh A,Gennaro D,Hoffstein S

doi

10.1038/328724a0

subject

Has Abstract

pub_date

1987-08-20 00:00:00

pages

724-6

issue

6132

eissn

0028-0836

issn

1476-4687

journal_volume

328

pub_type

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