A pressure-amplifying framework material with negative gas adsorption transitions.

abstract：:In many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane. The sustained entry of Ca2+ is thought to result partly from the depletion of intracellular Ca2+ pools. Most investigations have characterized Ca2+ influx indirectly by measuring Ca(2+)-activa...

journal_title：Nature

authors： Hoth M,Penner R

更新日期：1992-01-23 00:00:00

abstract：:Global conservation strategies commonly assume that different taxonomic groups show congruent geographical patterns of diversity, and that the distribution of extinction-prone species in one group can therefore act as a surrogate for vulnerable species in other groups when conservation decisions are being made. The va...

journal_title：Nature

authors： Grenyer R,Orme CD,Jackson SF,Thomas GH,Davies RG,Davies TJ,Jones KE,Olson VA,Ridgely RS,Rasmussen PC,Ding TS,Bennett PM,Blackburn TM,Gaston KJ,Gittleman JL,Owens IP

更新日期：2006-11-02 00:00:00

abstract：:Online hate and extremist narratives have been linked to abhorrent real-world events, including a current surge in hate crimes1-6 and an alarming increase in youth suicides that result from social media vitriol7; inciting mass shootings such as the 2019 attack in Christchurch, stabbings and bombings8-11; recruitment o...

journal_title：Nature

authors： Johnson NF,Leahy R,Restrepo NJ,Velasquez N,Zheng M,Manrique P,Devkota P,Wuchty S

更新日期：2019-09-01 00:00:00

abstract：:A consequence of relativity is that in the presence of an electric field, the spin and momentum states of an electron can be coupled; this is known as spin-orbit coupling. Such an interaction opens a pathway to the manipulation of electron spins within non-magnetic semiconductors, in the absence of applied magnetic fi...

journal_title：Nature

authors： Kato Y,Myers RC,Gossard AC,Awschalom DD

更新日期：2004-01-01 00:00:00

abstract：:The normal cellular form of prion protein (PrPC) is a precursor to the pathogenic protease-resistant forms (PrPSc) believed to cause scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease. Its amino terminus contains the octapeptide PHGGGWGQ, which is repeated four times and is among the best-pr...

journal_title：Nature

authors： Brown DR,Qin K,Herms JW,Madlung A,Manson J,Strome R,Fraser PE,Kruck T,von Bohlen A,Schulz-Schaeffer W,Giese A,Westaway D,Kretzschmar H

更新日期：1997-12-18 00:00:00

abstract：:Erythroid differentiation entails the biogenesis of a membrane skeleton, a network of proteins underlying and interacting with the plasma membrane, whose major constituent is the heterodimeric protein spectrin, composed of two structurally similar but distinct subunits, alpha (relative molecular mass (Mr) 240,000) and...

journal_title：Nature

authors： Woods CM,Lazarides E

更新日期：1986-05-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Smallman M

更新日期：2019-03-01 00:00:00

abstract：:Plants cope with the environment in a variety of ways, and ecological analyses attempt to capture this through life-history strategies or trait-based categorization. These approaches are limited because they treat the trade-off mechanisms that underlie plant responses as a black box. Approaches that involve the molecu...

journal_title：Nature

authors： Scheres B,van der Putten WH

更新日期：2017-03-15 00:00:00

abstract：:A report adopted by the Council of Europe lists eight recommendations on the legal, ethical, and social issues raised by recombinant DNA research. The legislators stressed that the right to a "genetic inheritance free from any form of engineering" should be included in the European Human Rights Convention, and that s...

journal_title：Nature

authors： Becker J

更新日期：1982-02-18 00:00:00

abstract：:Chronic myeloid leukaemia (CML) is caused by a defined genetic abnormality that generates BCR-ABL, a constitutively active tyrosine kinase. It is widely believed that BCR-ABL activates Akt signalling that suppresses the forkhead O transcription factors (FOXO), supporting the proliferation or inhibiting the apoptosis o...

journal_title：Nature

authors： Naka K,Hoshii T,Muraguchi T,Tadokoro Y,Ooshio T,Kondo Y,Nakao S,Motoyama N,Hirao A

更新日期：2010-02-04 00:00:00

abstract：:Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana...

journal_title：Nature

authors： Schacherer J,Shapiro JA,Ruderfer DM,Kruglyak L

更新日期：2009-03-19 00:00:00

abstract：:DNA repair by homologous recombination is highly suppressed in G1 cells to ensure that mitotic recombination occurs solely between sister chromatids. Although many homologous recombination factors are cell-cycle regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G...

journal_title：Nature

authors： Orthwein A,Noordermeer SM,Wilson MD,Landry S,Enchev RI,Sherker A,Munro M,Pinder J,Salsman J,Dellaire G,Xia B,Peter M,Durocher D

更新日期：2015-12-17 00:00:00

abstract：:Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans1. DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and p...

journal_title：Nature

authors： Wang L,Qian H,Nian Y,Han Y,Ren Z,Zhang H,Hu L,Prasad BVV,Laganowsky A,Yan N,Zhou M

更新日期：2020-05-01 00:00:00

abstract：:Change history: In Fig. 1b and c of this Letter, the inset times in the DIC and GFP microscopy images should be in minutes ('min') instead of seconds ('s'). This has not been corrected online. ...

journal_title：Nature

authors： Stewart MP,Helenius J,Toyoda Y,Ramanathan SP,Muller DJ,Hyman AA

更新日期：2019-07-01 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:Several distinct cell lineages are established during mouse embryogenesis. The trophectoderm and primitive endoderm give rise to extraembryonic structures alone, while the primitive ectoderm becomes the fetus proper. Recent studies suggest that the levels of DNA modification are lower in inactive X chromosomes from ex...

journal_title：Nature

authors： Chapman V,Forrester L,Sanford J,Hastie N,Rossant J

更新日期：1984-01-19 00:00:00

abstract：:Ubiquitin, a 76-residue protein, occurs in cells either free or covalently joined to a variety of protein species, from chromosomal histones to cytoplasmic proteins. Conjugation of ubiquitin to proteolytic substrates is essential for the selective degradation of intracellular proteins in higher eukaryotes. We show her...

journal_title：Nature

authors： Ozkaynak E,Finley D,Varshavsky A

更新日期：1984-12-13 00:00:00

abstract：:Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...

journal_title：Nature

authors： Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ

更新日期：2020-09-01 00:00:00

abstract：:The brain cholecystokinin-B/gastrin receptor (CCK-B/gastrin) has been implicated in mediating anxiety, panic attacks, satiety, and the perception of pain. The canine and human CCK-B/gastrin receptors share 90% amino-acid identity and have similar agonist affinities. These receptors can be selectively blocked by the no...

journal_title：Nature

authors： Beinborn M,Lee YM,McBride EW,Quinn SM,Kopin AS

更新日期：1993-03-25 00:00:00

abstract：:In Xenopus the c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation, for the progression from meiosis I to meiosis II and for the second meiotic metaphase arrest, acting as an essential component of the cytostatic factor CSF. Its function in mouse oocytes is unclear, however, as is t...

journal_title：Nature

authors： Hashimoto N,Watanabe N,Furuta Y,Tamemoto H,Sagata N,Yokoyama M,Okazaki K,Nagayoshi M,Takeda N,Ikawa Y

更新日期：1994-07-07 00:00:00

abstract：:The recent discovery that the human T-cell lymphoma leukemia virus (HTLV) may be the agent of transmission of T-cell lymphoid malignancies raises ethical questions for blood transfusion services. The effort to avoid use of contaminated blood is dependent to a large extent on the willingness and ability of donors to g...

journal_title：Nature

authors：

更新日期：1983-04-14 00:00:00

abstract：:Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. Most synapses that exhibit LTP use an excitatory amino-acid neurotransmitter that acts on two types of rec...

journal_title：Nature

authors： Davies SN,Lester RA,Reymann KG,Collingridge GL

更新日期：1989-04-06 00:00:00

abstract：:The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a re...

journal_title：Nature

authors： Hemmings HC Jr,Greengard P,Tung HY,Cohen P

更新日期：1984-08-09 00:00:00

abstract：:The majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, HIV, Ebola and SARS). Understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals f...

journal_title：Nature

authors： Olival KJ,Hosseini PR,Zambrana-Torrelio C,Ross N,Bogich TL,Daszak P

更新日期：2017-06-29 00:00:00

abstract：:Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure1-9, whereas excess activity can contribute to bone loss and osteoporosis10....

journal_title：Nature

authors： Jacome-Galarza CE,Percin GI,Muller JT,Mass E,Lazarov T,Eitler J,Rauner M,Yadav VK,Crozet L,Bohm M,Loyher PL,Karsenty G,Waskow C,Geissmann F

更新日期：2019-04-01 00:00:00

abstract：:Nuclear magic numbers correspond to fully occupied energy shells of protons or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. Although the sequence of magic numbers is well established for stable nucle...

journal_title：Nature

authors： Taniuchi R,Santamaria C,Doornenbal P,Obertelli A,Yoneda K,Authelet G,Baba H,Calvet D,Château F,Corsi A,Delbart A,Gheller JM,Gillibert A,Holt JD,Isobe T,Lapoux V,Matsushita M,Menéndez J,Momiyama S,Motobayashi T,Nii

更新日期：2019-05-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGRF seems to be important for its biological effects, as reduction irreve...

journal_title：Nature

authors： Heldin CH,Johnsson A,Wennergren S,Wernstedt C,Betsholtz C,Westermark B

更新日期：1986-02-06 00:00:00

abstract：:Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...

journal_title：Nature

authors： Knossow M,Daniels RS,Douglas AR,Skehel JJ,Wiley DC

更新日期：1984-10-18 00:00:00

abstract：:Compartments in food webs are subgroups of taxa in which many strong interactions occur within the subgroups and few weak interactions occur between the subgroups. Theoretically, compartments increase the stability in networks, such as food webs. Compartments have been difficult to detect in empirical food webs becaus...

journal_title：Nature

authors： Krause AE,Frank KA,Mason DM,Ulanowicz RE,Taylor WW

更新日期：2003-11-20 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate (PIP2), which comprises only about 1% of the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three second messengers, activates many ion channels and enzymes, is involved in both endocytosis and exocytosis, anchors proteins to the membrane through...

journal_title：Nature

authors： McLaughlin S,Murray D

更新日期：2005-12-01 00:00:00