Abstract:
:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with DC-targeted vaccines. During allergy, autoimmunity and transplant rejection, DCs instigate unwanted responses that cause disease, but, again, DCs can be harnessed to silence these conditions with novel therapies. Here we present some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy.
journal_name
Naturejournal_title
Natureauthors
Steinman RM,Banchereau Jdoi
10.1038/nature06175subject
Has Abstractpub_date
2007-09-27 00:00:00pages
419-26issue
7161eissn
0028-0836issn
1476-4687pii
nature06175journal_volume
449pub_type
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