Abstract:
:During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell.
journal_name
Naturejournal_title
Natureauthors
Fraser RS,Nurse Pdoi
10.1038/271726a0subject
Has Abstractpub_date
1978-02-23 00:00:00pages
726-30issue
5647eissn
0028-0836issn
1476-4687journal_volume
271pub_type
杂志文章相关文献
NATURE文献大全abstract::In developing mammalian muscle, axon branches of several motor neurons co-innervate the same muscle fibre. Competition among them results in the strengthening of one and the withdrawal of the rest. It is not known why one particular axon branch survives or why some competitions resolve sooner than others. Here we show...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01836
更新日期:2003-07-24 00:00:00
abstract::The purified p21src protein of Harvey sarcoma virus shows a guanine nucleotide-binding activity and, in addition, at elevated temperature an autophosphorylating activity at a threonine residue using as phosphoryl donor GTP or dGTP but not ATP or dATP. These biochemical activities are unique among those associated with...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287686a0
更新日期:1980-10-23 00:00:00
abstract::During intracellular Ca2+ signalling mitochondria accumulate significant amounts of Ca2+ from the cytosol. Mitochondrial Ca2+ uptake controls the rate of energy production, shapes the amplitude and spatio-temporal patterns of intracellular Ca2+ signals, and is instrumental to cell death. This Ca2+ uptake is undertaken...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02246
更新日期:2004-01-22 00:00:00
abstract::Proximal spinal muscular atrophies represent the second most common fatal, autosomal recessive disorder after cystic fibrosis. The childhood form is classically subdivided into three groups: acute Werdnig-Hoffmann (type I), intermediate Werdnig-Hoffmann disease (type II) and Kugelberg-Welander disease (type III). Thes...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344767a0
更新日期:1990-04-19 00:00:00
abstract::Many small proteins seem to fold by a simple process explicable by conventional chemical kinetics and transition-state theory. This assumes an instant equilibrium between reactants and a high-energy activated state. In reality, equilibration occurs on timescales dependent on the molecules involved, below which such an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01609
更新日期:2003-05-08 00:00:00
abstract::Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporid...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02977
更新日期:2004-10-28 00:00:00
abstract::The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35055553
更新日期:2001-02-08 00:00:00
abstract::The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09278
更新日期:2010-08-05 00:00:00
abstract::Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bon...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346850a0
更新日期:1990-08-30 00:00:00
abstract::Sex in birds is chromosomally based, as in mammals, but the sex chromosomes are different and the mechanism of avian sex determination has been a long-standing mystery. In the chicken and all other birds, the homogametic sex is male (ZZ) and the heterogametic sex is female (ZW). Two hypotheses have been proposed for t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08298
更新日期:2009-09-10 00:00:00
abstract::Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00906
更新日期:2002-08-01 00:00:00
abstract::Vitamin A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process. Recent evidence indicates that RA acts through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. The receptors seem to associate with hormone-resp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339231a0
更新日期:1989-05-18 00:00:00
abstract::In the prehistoric green Sahara of Holocene North Africa-in contrast to the Neolithic of Europe and Eurasia-a reliance on cattle, sheep and goats emerged as a stable and widespread way of life, long before the first evidence for domesticated plants or settled village farming communities. The remarkable rock art found ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11186
更新日期:2012-06-20 00:00:00
abstract::Three Hipparion trails, two from adults and one from a juvenile dating from about 3.5 Myr ago, have now been found in Laetoli. Comparison of the Hipparion footprints with a variety of imprints made by domestic horses showed that the animals moved with a running walk over the soft and slippery soil of Laetoli: in the a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308179a0
更新日期:1984-03-08 00:00:00
abstract::Alternative splicing of eukaryotic messenger RNA precursors is now known to be of widespread importance in generating multiple transcripts from a single gene. This phenomenon has emphasized the problem of the way in which splice sites are selected; recent studies have discussed the role of secondary structure or affin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324280a0
更新日期:1986-11-20 00:00:00
abstract::The sequence-specific DNA-binding protein, MyoD, can activate muscle-specific gene expression in some cells in culture. Xenopus MyoD (XMyoD) transcription is activated as a consequence of mesoderm induction in the early myotomes, from which the axial musculature develops. XMyoD RNA accumulates about two hours before m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347197a0
更新日期:1990-09-13 00:00:00
abstract::The relay of information through thalamus to cortex is dynamically gated, as illustrated by the retinogeniculocortical pathway. Important to this is the inhibitory interneuron in the lateral geniculate nucleus (LGN). For the typical neuron, synaptic information arrives through postsynaptic dendrites and is transmitted...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/28855
更新日期:1998-07-30 00:00:00
abstract::Glucagon is a 29-amino-acid peptide released from the α-cells of the islet of Langerhans, which has a key role in glucose homeostasis. Glucagon action is transduced by the class B G-protein-coupled glucagon receptor (GCGR), which is located on liver, kidney, intestinal smooth muscle, brain, adipose tissue, heart and p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17414
更新日期:2016-05-12 00:00:00
abstract::For many decades comparative analyses of protein sequences and structures have been used to investigate fundamental principles of molecular evolution. In contrast, relatively little is known about the long-term evolution of species' phenotypic and genetic properties. This represents an important gap in our understandi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13827
更新日期:2015-01-15 00:00:00
abstract::Sleep is one of the few major whole-organ phenomena for which no function and no underlying mechanism have been conclusively demonstrated. Sleep could result from global changes in the brain during wakefulness or it could be regulated by specific loci that recruit the rest of the brain into the electrical and metaboli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04811
更新日期:2006-06-08 00:00:00
abstract::An amino acid sequence analysis of the N-terminal immunoglobulin heavy and light chain variable regions (VH and VL) from 16 hybridoma proteins which bind phosphorylcholine as well as the complete sequence analysis of 9 of these VH regions is presented. There seem to be more VH regions participating in the phosphorylch...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/291029a0
更新日期:1981-05-07 00:00:00
abstract::Galaxies congregate in clusters and along filaments, and are missing from large regions referred to as voids. These structures are seen in maps derived from spectroscopic surveys that reveal networks of structure that are interconnected with no clear boundaries. Extended regions with a high concentration of galaxies a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13674
更新日期:2014-09-04 00:00:00
abstract::Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/387268a0
更新日期:1997-05-15 00:00:00
abstract::Piezoelectric materials, which convert mechanical to electrical energy (and vice versa), are crucial in medical imaging, telecommunication and ultrasonic devices. A new generation of single-crystal materials, such as Pb(Zn1/3Nb2/3)O3-PbTiO3 (PZN-PT) and Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT), exhibit a piezoelectric effect ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35002022
更新日期:2000-01-20 00:00:00
abstract::A long-sought goal in structural biology has been the imaging of membrane proteins in their membrane environments. This goal has been achieved with electron crystallography in those special cases where a protein forms highly ordered arrays in lipid bilayers. It has also been achieved by NMR methods in proteins up to 5...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08291
更新日期:2009-09-10 00:00:00
abstract::Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic trans...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05324
更新日期:2006-11-23 00:00:00
abstract::The selection and design of modern high-performance structural engineering materials is driven by optimizing combinations of mechanical properties such as strength, ductility, toughness, elasticity and requirements for predictable and graceful (non-catastrophic) failure in service. Highly processable bulk metallic gla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06598
更新日期:2008-02-28 00:00:00
abstract::Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling through the transcription factor GLI. Although inhibitors of membrane protein smoothened (SMO) effectively suppress HH signalling, early tumour resistance illustrates the need for additional downstream targets for therapy. Here we ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11889
更新日期:2013-02-28 00:00:00
abstract::Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02020
更新日期:2003-10-02 00:00:00
abstract::The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323728a0
更新日期:1986-10-23 00:00:00