Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.

abstract：:The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between ...

journal_title：Nature

authors： Rulifson EJ,Micchelli CA,Axelrod JD,Perrimon N,Blair SS

更新日期：1996-11-07 00:00:00

abstract：:The Colorado plateau is a large, tectonically intact, physiographic province in the southwestern North American Cordillera that stands at ∼1,800-2,000 m elevation and has long been thought to be in isostatic equilibrium. The origin of these high elevations is unclear because unlike the surrounding provinces, which hav...

journal_title：Nature

authors： Levander A,Schmandt B,Miller MS,Liu K,Karlstrom KE,Crow RS,Lee CT,Humphreys ED

更新日期：2011-04-28 00:00:00

abstract：:Courtship is an innate sexually dimorphic behaviour that can be observed in naive animals without previous learning or experience, suggesting that the neural circuits that mediate this behaviour are developmentally programmed. In Drosophila, courtship involves a complex yet stereotyped array of dimorphic behaviours th...

journal_title：Nature

authors： Datta SR,Vasconcelos ML,Ruta V,Luo S,Wong A,Demir E,Flores J,Balonze K,Dickson BJ,Axel R

更新日期：2008-03-27 00:00:00

abstract：:High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....

journal_title：Nature

authors： Balakirev FF,Betts JB,Migliori A,Ono S,Ando Y,Boebinger GS

更新日期：2003-08-21 00:00:00

abstract：:A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads a...

journal_title：Nature

authors： Liu J,O'Brien KL,Lynch DM,Simmons NL,La Porte A,Riggs AM,Abbink P,Coffey RT,Grandpre LE,Seaman MS,Landucci G,Forthal DN,Montefiori DC,Carville A,Mansfield KG,Havenga MJ,Pau MG,Goudsmit J,Barouch DH

更新日期：2009-01-01 00:00:00

abstract：:The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...

journal_title：Nature

authors： Vogel US,Dixon RA,Schaber MD,Diehl RE,Marshall MS,Scolnick EM,Sigal IS,Gibbs JB

更新日期：1988-09-01 00:00:00

abstract：:Recent work has defined a class of transcriptional activators, members of which activate transcription in yeast, plant, insect and mammalian cells. These proteins contain two parts: one directs DNA binding and the other, called the activating region, presumably interacts with some component of the transcriptional mach...

journal_title：Nature

authors： Sadowski I,Ma J,Triezenberg S,Ptashne M

更新日期：1988-10-06 00:00:00

abstract：:The heavy (H) and light (L) chains of antibodies consist of variable (V) and constant (C) regions. The V regions of the heavy and light chains form the antibody combining site. To determine whether a V region could be functional when joined to a polypeptide other than its own C region, we constructed a chimaeric gene ...

journal_title：Nature

authors： Sharon J,Gefter ML,Manser T,Morrison SL,Oi VT,Ptashne M

更新日期：1984-05-24 00:00:00

abstract：:Fullerenes are graphitic cage structures incorporating exactly twelve pentagons. The smallest possible fullerene is thus C20, which consists solely of pentagons. But the extreme curvature and reactivity of this structure have led to doubts about its existence and stability. Although theoretical calculations have ident...

journal_title：Nature

authors： Prinzbach H,Weiler A,Landenberger P,Wahl F,Worth J,Scott LT,Gelmont M,Olevano D,v. Issendorff B

更新日期：2000-09-07 00:00:00

abstract：:During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...

journal_title：Nature

authors： Bina CR,Navrotsky A

更新日期：2000-12-14 00:00:00

abstract：:A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...

journal_title：Nature

authors： Montell C,Fisher EF,Caruthers MH,Berk AJ

更新日期：1983-10-13 00:00:00

abstract：:Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. ...

journal_title：Nature

authors： Stockwell BR

更新日期：2004-12-16 00:00:00

abstract：:The axial relationship between the collagen and mineral componetns in calcified turkey leg tendon was investigated using low-angle X-ray and neutron diffraction. The results indicate that the mineral is arranged with the same axial periodicity as the collagen and occupies the gap region of the collagen structure. ...

journal_title：Nature

authors： White SW,Hulmes DJ,Miller A,Timmins PA

更新日期：1977-03-31 00:00:00

abstract：:A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. ...

journal_title：Nature

authors： Murre C,Reiss CS,Bernabeu C,Chen LB,Burakoff SJ,Seidman JG

更新日期：1984-02-02 00:00:00

abstract：:Analogous to the progression of events in the opiate receptor-enkaphalin area, the first reports that benzodiazepines have selective and specific high-affinity binding sites in brain have stimulated a search for the endogenous 'ligand' or substance that might normally act at these sites. Braestrup and co-workers have ...

journal_title：Nature

authors： Tenen SS,Hirsch JD

更新日期：1980-12-11 00:00:00

abstract：:A 7-A resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, alpha-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the s...

journal_title：Nature

authors： Henderson R,Unwin PN

更新日期：1975-09-04 00:00:00

abstract：: ...

journal_title：Nature

authors： Glausiusz J

更新日期：2019-01-01 00:00:00

abstract：:T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). Mutations in the genes for Fas and FasL cause disorders resembling human autoimmune diseases in lpr and gld mice, respectively. However, peripheral T-cell deletion takes place in...

journal_title：Nature

authors： Zheng L,Fisher G,Miller RE,Peschon J,Lynch DH,Lenardo MJ

更新日期：1995-09-28 00:00:00

abstract：:Protein design provides a rigorous test of our knowledge about proteins and allows the creation of novel enzymes for biotechnological applications. Whereas progress has been made in designing proteins that mimic native proteins structurally, it is more difficult to design functional proteins. In comparison to recent s...

journal_title：Nature

authors： Yeung N,Lin YW,Gao YG,Zhao X,Russell BS,Lei L,Miner KD,Robinson H,Lu Y

更新日期：2009-12-24 00:00:00

abstract：:The availability of methods for the amplification of nucleic acid sequences allows the genetic analysis in vitro of the structural and functional properties of many nucleic acids. We have now developed an in vitro selection and amplification system, and used it to analyse the self-splicing Tetrahymena ribozyme. A much...

journal_title：Nature

authors： Green R,Ellington AD,Szostak JW

更新日期：1990-09-27 00:00:00

abstract：:Cellulose is the major polysaccharide component of plant cell walls and is the most abundant organic compound on the planet. A number of bacterial and fungal organisms can use cellulose as a food source, possessing cellulases (cellobiohydrolases and endoglucanases) that can catalyse the hydrolysis of the beta-(1,4) gl...

journal_title：Nature

authors： Davies GJ,Dodson GG,Hubbard RE,Tolley SP,Dauter Z,Wilson KS,Hjort C,Mikkelsen JM,Rasmussen G,Schülein M

更新日期：1993-09-23 00:00:00

abstract：:The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we directly test for increased transcriptional noise in aged tissue by di...

journal_title：Nature

authors： Bahar R,Hartmann CH,Rodriguez KA,Denny AD,Busuttil RA,Dollé ME,Calder RB,Chisholm GB,Pollock BH,Klein CA,Vijg J

更新日期：2006-06-22 00:00:00

abstract：:Melting processes in the deep mantle have important implications for the origin of the deep-derived plumes believed to feed hotspot volcanoes such as those in Hawaii. They also provide insight into how the mantle has evolved, geochemically and dynamically, since the formation of Earth. Melt production in the shallow m...

journal_title：Nature

authors： Andrault D,Petitgirard S,Lo Nigro G,Devidal JL,Veronesi G,Garbarino G,Mezouar M

更新日期：2012-07-18 00:00:00

abstract：:The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...

journal_title：Nature

authors： Richardson JD,Kasper JC,Wang C,Belcher JW,Lazarus AJ

更新日期：2008-07-03 00:00:00

abstract：:Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutr...

journal_title：Nature

authors： Wellenstein MD,Coffelt SB,Duits DEM,van Miltenburg MH,Slagter M,de Rink I,Henneman L,Kas SM,Prekovic S,Hau CS,Vrijland K,Drenth AP,de Korte-Grimmerink R,Schut E,van der Heijden I,Zwart W,Wessels LFA,Schumacher TN,Jonk

更新日期：2019-08-01 00:00:00

abstract：:Novel capsomeric complexes, pentamers and hexamers were detected as chemical entities in phage Q beta. Both were composed of identical protein subunits and stabilized by intermolecular disulphide bonds. Their numbers per particle were about 12 for pentamers and about 20 for hexamers--consistent with theoretical expect...

journal_title：Nature

authors： Takamatsu H,Iso K

更新日期：1982-08-26 00:00:00

abstract：:Protecting the world's freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts f...

journal_title：Nature

authors： Vörösmarty CJ,McIntyre PB,Gessner MO,Dudgeon D,Prusevich A,Green P,Glidden S,Bunn SE,Sullivan CA,Liermann CR,Davies PM

更新日期：2010-09-30 00:00:00

abstract：:Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...

journal_title：Nature

authors： Witkowski FX,Leon LJ,Penkoske PA,Giles WR,Spano ML,Ditto WL,Winfree AT

更新日期：1998-03-05 00:00:00

abstract：:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from D...

journal_title：Nature

authors： McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MA

更新日期：2002-07-04 00:00:00

abstract：:Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abi...

journal_title：Nature

authors： Asangani IA,Dommeti VL,Wang X,Malik R,Cieslik M,Yang R,Escara-Wilke J,Wilder-Romans K,Dhanireddy S,Engelke C,Iyer MK,Jing X,Wu YM,Cao X,Qin ZS,Wang S,Feng FY,Chinnaiyan AM

更新日期：2014-06-12 00:00:00