Collagen-mineral axial relationship in calcified turkey leg tendon by X-ray and neutron diffraction.

abstract：:Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...

journal_title：Nature

authors： Erickson CL

更新日期：2000-11-09 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Antiviral T cells are thought to regulate whether hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or severe disease, although the reasons for these different outcomes remain unclear. Recent genetic evidence, however, has indicated a correlatio...

journal_title：Nature

authors： Waggoner SN,Cornberg M,Selin LK,Welsh RM

更新日期：2011-11-20 00:00:00

abstract：:The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New a...

journal_title：Nature

authors： Barker RA,Götz M,Parmar M

更新日期：2018-05-01 00:00:00

abstract：:Resolving current concerns about the role of biodiversity on ecosystems calls for understanding the separate roles of changes in species numbers and of composition. Recent work shows that primary productivity often, but not always, saturates with species richness within single trophic levels. However, any interpretati...

journal_title：Nature

authors： Downing AL,Leibold MA

更新日期：2002-04-25 00:00:00

abstract：:The split promoter sequences of a tRNALeuCUG gene of Xenopus laevis have been mapped to nucleotides 13-20 and 51-64 of the tRNALeu coding sequences. The sequences closely coincide with two conserved sequence blocks present in all eukaryotic tRNA genes. The two conserved sequence blocks were found to be exchangeable be...

journal_title：Nature

authors： Galli G,Hofstetter H,Birnstiel ML

更新日期：1981-12-17 00:00:00

abstract：:The restriction of intermingling between specific cell populations is crucial for the maintenance of organized patterns during development. A striking example is the restriction of cell mixing between segments in the insect epidermis and the vertebrate hindbrain that may enable each segment to maintain a distinct iden...

journal_title：Nature

authors： Xu Q,Mellitzer G,Robinson V,Wilkinson DG

更新日期：1999-05-20 00:00:00

abstract：:The T-cell receptor (TCR) repertoire is selected in the thymus after rearrangement of genes encoding TCR alpha and beta chains. Selection is based on the recognition by newly emergent T cells of self-ligands associated with molecules of the major histocompatibility complex: some combinations result in positive selecti...

journal_title：Nature

authors： Dyson PJ,Knight AM,Fairchild S,Simpson E,Tomonari K

更新日期：1991-02-07 00:00:00

abstract：:The identification of properties that contribute to the persistence and resilience of ecosystems despite climate change constitutes a research priority of global relevance. Here we present a novel, empirical approach to assess the relative sensitivity of ecosystems to climate variability, one property of resilience th...

journal_title：Nature

authors： Seddon AW,Macias-Fauria M,Long PR,Benz D,Willis KJ

更新日期：2016-03-10 00:00:00

abstract：:Temperature and fluid pressure conditions control rock deformation and mineralization on geological faults, and hence the distribution of earthquakes. Typical intraplate continental crust has hydrostatic fluid pressure and a near-surface thermal gradient of 31 ± 15 degrees Celsius per kilometre. At temperatures above ...

journal_title：Nature

authors： Sutherland R,Townend J,Toy V,Upton P,Coussens J,Allen M,Baratin LM,Barth N,Becroft L,Boese C,Boles A,Boulton C,Broderick NGR,Janku-Capova L,Carpenter BM,Célérier B,Chamberlain C,Cooper A,Coutts A,Cox S,Craw L,Do

更新日期：2017-06-01 00:00:00

abstract：:Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...

journal_title：Nature

authors： Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Grif

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-01-01 00:00:00

abstract：:The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific...

journal_title：Nature

authors： Graves BJ,Crowther RL,Chandran C,Rumberger JM,Li S,Huang KS,Presky DH,Familletti PC,Wolitzky BA,Burns DK

更新日期：1994-02-10 00:00:00

abstract：:There are large amounts of heavy alpha-emitters in nuclear waste and nuclear materials inventories stored in various sites around the world. These include plutonium and minor actinides such as americium and curium. In preparation for geological disposal there is consensus that actinides that have been separated from s...

journal_title：Nature

authors： Farnan I,Cho H,Weber WJ

更新日期：2007-01-11 00:00:00

abstract：:A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...

journal_title：Nature

authors： Nguyen NUN,Canseco DC,Xiao F,Nakada Y,Li S,Lam NT,Muralidhar SA,Savla JJ,Hill JA,Le V,Zidan KA,El-Feky HW,Wang Z,Ahmed MS,Hubbi ME,Menendez-Montes I,Moon J,Ali SR,Le V,Villalobos E,Mohamed MS,Elhelaly WM,Thet

更新日期：2020-06-01 00:00:00

abstract：:Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...

journal_title：Nature

authors： Boersma V,Moatti N,Segura-Bayona S,Peuscher MH,van der Torre J,Wevers BA,Orthwein A,Durocher D,Jacobs JJL

更新日期：2015-05-28 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00

abstract：:Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...

journal_title：Nature

authors： Reisz RR,Huang TD,Roberts EM,Peng S,Sullivan C,Stein K,LeBlanc AR,Shieh D,Chang R,Chiang C,Yang C,Zhong S

更新日期：2013-04-11 00:00:00

abstract：:The satellites Rhea and Dione orbit within the magnetosphere of Saturn, where they are exposed to particle irradiation from trapped ions. A similar situation applies to the galilean moons Europa, Ganymede and Callisto, which reside within Jupiter's radiation belts. All of these satellites have surfaces rich in water i...

journal_title：Nature

authors： Noll KS,Roush TL,Cruikshank DP,Johnson RE,Pendleton YJ

更新日期：1997-07-03 00:00:00

abstract：:In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebra...

journal_title：Nature

authors： Krauss S,Johansen T,Korzh V,Fjose A

更新日期：1991-09-19 00:00:00

abstract：:In legumes, root nodule organogenesis is activated in response to morphogenic lipochitin oligosaccharides that are synthesized by bacteria, commonly known as rhizobia. Successful symbiotic interaction results in the formation of highly specialized organs called root nodules, which provide a unique environment for symb...

journal_title：Nature

authors： Krusell L,Madsen LH,Sato S,Aubert G,Genua A,Szczyglowski K,Duc G,Kaneko T,Tabata S,de Bruijn F,Pajuelo E,Sandal N,Stougaard J

更新日期：2002-11-28 00:00:00

abstract：:The TGF-beta/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. The signal originated by TGF-beta-like molecules appears to be transduced by a set of evolutionarily conserved proteins known as SMADs, which upon activation di...

journal_title：Nature

authors： Lagna G,Hata A,Hemmati-Brivanlou A,Massagué J

更新日期：1996-10-31 00:00:00

abstract：:Transport of fermions, particles with half-integer spin, is central to many fields of physics. Electron transport runs modern technology, defining states of matter such as superconductors and insulators, and electron spin is being explored as a new carrier of information. Neutrino transport energizes supernova explosi...

journal_title：Nature

authors： Sommer A,Ku M,Roati G,Zwierlein MW

更新日期：2011-04-14 00:00:00

abstract：:In myelinated nerves, segregation of voltage-dependent sodium channels to nodes of Ranvier is crucial for saltatory conduction along axons. As sodium channels associate and colocalize with ankyrin at nodes of Ranvier, one possibility is that sodium channels are recruited and immobilized at axonal sites which are speci...

journal_title：Nature

authors： Joe EH,Angelides K

更新日期：1992-03-26 00:00:00

abstract：:Two principals in the once-raging debate over forensic DNA typing conclude that the scientific issues have all been resolved. ...

journal_title：Nature

authors： Lander ES,Budowle B

更新日期：1994-10-27 00:00:00

abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...

journal_title：Nature

authors： Agarwal J,Jewitt D,Mutchler M,Weaver H,Larson S

更新日期：2017-09-20 00:00:00

abstract：:In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...

journal_title：Nature

authors： Gao J,Barzel B,Barabási AL

更新日期：2019-04-01 00:00:00

abstract：:After an earthquake, numerous smaller shocks are triggered over distances comparable to the dimensions of the mainshock fault rupture, although they are rare at larger distances. Here we analyse the scaling of dynamic deformations (the stresses and strains associated with seismic waves) with distance from, and magnitu...

journal_title：Nature

authors： Gomberg J,Johnson P

更新日期：2005-10-06 00:00:00

abstract：:The ability to form integrated circuits on flexible sheets of plastic enables attributes (for example conformal and flexible formats and lightweight and shock resistant construction) in electronic devices that are difficult or impossible to achieve with technologies that use semiconductor wafers or glass plates as sub...

journal_title：Nature

authors： Cao Q,Kim HS,Pimparkar N,Kulkarni JP,Wang C,Shim M,Roy K,Alam MA,Rogers JA

更新日期：2008-07-24 00:00:00

abstract：:Since the original work on Bose-Einstein condensation1,2, the use of quantum degenerate gases of atoms has enabled the quantum emulation of important systems in condensed matter and nuclear physics, as well as the study of many-body states that have no analogue in other fields of physics3. Ultracold molecules in the m...

journal_title：Nature

authors： Son H,Park JJ,Ketterle W,Jamison AO

更新日期：2020-04-01 00:00:00