Collagen-mineral axial relationship in calcified turkey leg tendon by X-ray and neutron diffraction.


:The axial relationship between the collagen and mineral componetns in calcified turkey leg tendon was investigated using low-angle X-ray and neutron diffraction. The results indicate that the mineral is arranged with the same axial periodicity as the collagen and occupies the gap region of the collagen structure.






White SW,Hulmes DJ,Miller A,Timmins PA




Has Abstract


1977-03-31 00:00:00














  • Control of tension development in scallop muscle fibres with foreign regulatory light chains.

    abstract::We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...


    pub_type: 杂志文章


    authors: Simmons RM,Szent-Györgyi AG

    更新日期:1980-08-07 00:00:00

  • Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus.

    abstract::The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism conv...


    pub_type: 杂志文章


    authors: Windass JD,Worsey MJ,Pioli EM,Pioli D,Barth PT,Atherton KT,Dart EC,Byrom D,Powell K,Senior PJ

    更新日期:1980-10-02 00:00:00

  • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis.

    abstract::Multiple sclerosis is thought to be an autoimmune disease of the central nervous system mediated by T cells specific for a myelin antigen. Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in experimental autoimmune encephalomyelitis and post-viral...


    pub_type: 杂志文章


    authors: Ota K,Matsui M,Milford EL,Mackin GA,Weiner HL,Hafler DA

    更新日期:1990-07-12 00:00:00

  • Early brain growth in Homo erectus and implications for cognitive ability.

    abstract::Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...


    pub_type: 历史文章,杂志文章


    authors: Coqueugniot H,Hublin JJ,Veillon F,Houët F,Jacob T

    更新日期:2004-09-16 00:00:00

  • Hypothalamic regulation of sleep and circadian rhythms.

    abstract::A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal s...


    pub_type: 杂志文章,评审


    authors: Saper CB,Scammell TE,Lu J

    更新日期:2005-10-27 00:00:00

  • Predicting disease using genomics.

    abstract::Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...


    pub_type: 杂志文章,评审


    authors: Bell J

    更新日期:2004-05-27 00:00:00

  • Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli.

    abstract::Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may underlie a diversity of functions is by modulating the signal-to-noise ratio in subpopulations of mPFC ...


    pub_type: 杂志文章


    authors: Vander Weele CM,Siciliano CA,Matthews GA,Namburi P,Izadmehr EM,Espinel IC,Nieh EH,Schut EHS,Padilla-Coreano N,Burgos-Robles A,Chang CJ,Kimchi EY,Beyeler A,Wichmann R,Wildes CP,Tye KM

    更新日期:2018-11-01 00:00:00

  • Loss-free and active optical negative-index metamaterials.

    abstract::The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...


    pub_type: 杂志文章


    authors: Xiao S,Drachev VP,Kildishev AV,Ni X,Chettiar UK,Yuan HK,Shalaev VM

    更新日期:2010-08-05 00:00:00

  • The TLR4 antagonist Eritoran protects mice from lethal influenza infection.

    abstract::There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous studies reported that acute lung injury caused by chemical or microbial insults is secondary to the generation of host-derived, oxidized phospholipid that potently st...


    pub_type: 杂志文章


    authors: Shirey KA,Lai W,Scott AJ,Lipsky M,Mistry P,Pletneva LM,Karp CL,McAlees J,Gioannini TL,Weiss J,Chen WH,Ernst RK,Rossignol DP,Gusovsky F,Blanco JC,Vogel SN

    更新日期:2013-05-23 00:00:00

  • Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.

    abstract::The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small cell lung cancers harbouring activating mutations in the EGFR kinase, but resistance arises rapidly, most frequently owing to the secondary T790M mutation withi...


    pub_type: 杂志文章


    authors: Jia Y,Yun CH,Park E,Ercan D,Manuia M,Juarez J,Xu C,Rhee K,Chen T,Zhang H,Palakurthi S,Jang J,Lelais G,DiDonato M,Bursulaya B,Michellys PY,Epple R,Marsilje TH,McNeill M,Lu W,Harris J,Bender S,Wong KK,Jänne PA

    更新日期:2016-06-02 00:00:00

  • An enzymatic Alder-ene reaction.

    abstract::An ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactions of complex molecules. Chemists rely on organocatalysts or transition metal catalysts to control stereoselectivity, regioselectivity and periselectivity (selectivity among possible pericyclic reactions). Nature ac...


    pub_type: 杂志文章


    authors: Ohashi M,Jamieson CS,Cai Y,Tan D,Kanayama D,Tang MC,Anthony SM,Chari JV,Barber JS,Picazo E,Kakule TB,Cao S,Garg NK,Zhou J,Houk KN,Tang Y

    更新日期:2020-10-01 00:00:00

  • Structure and elasticity of microtubule-associated protein tau.

    abstract::Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. It occurs in the mammalian brain, mainly in axons, and is a component of the neurofibrillary tangles of Alzheimer's disease. Tau was recently sequenced, but there remains...


    pub_type: 杂志文章


    authors: Lichtenberg B,Mandelkow EM,Hagestedt T,Mandelkow E

    更新日期:1988-07-28 00:00:00

  • Differential usage of iso-accepting tRNASer species in silk glands of Bombyx mori.

    abstract::The rapid development of the silk glands of Bombyx mori during the last larval instar shows two phases. During the first 4 days, in both the middle and posterior parts of the silk glands, the ribosomal machinery is assembled and the synthesis of housekeeping proteins starts. During the second phase (the last 4 days), ...


    pub_type: 杂志文章


    authors: Hentzen D,Chevallier A,Garel JP

    更新日期:1981-03-19 00:00:00

  • The physical mechanisms of fast radio bursts.

    abstract::Fast radio bursts are mysterious millisecond-duration transients prevalent in the radio sky. Rapid accumulation of data in recent years has facilitated an understanding of the underlying physical mechanisms of these events. Knowledge gained from the neighbouring fields of gamma-ray bursts and radio pulsars has also of...


    pub_type: 杂志文章,评审


    authors: Zhang B

    更新日期:2020-11-01 00:00:00

  • Transposition of Tn554 does not generate a target duplication.

    abstract::Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...


    pub_type: 杂志文章


    authors: Murphy E,Löfdahl S

    更新日期:1984-01-19 00:00:00

  • A 100th birthday wish: uphold academic freedom in dark times.

    abstract:: ...


    pub_type: 历史文章,新闻


    authors: Masood E

    更新日期:2018-11-01 00:00:00

  • In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell population.

    abstract::It is well established that the osteoclast is formed by fusion of post-mitotic, mononuclear precursors derived from circulating progenitor cells. However, the precise haematopoietic origin of the osteoclast is unknown. We have investigated this here by fractionating mouse bone marrow and isolating haematopoietic stem ...


    pub_type: 杂志文章


    authors: Scheven BA,Visser JW,Nijweide PJ

    更新日期:1986-05-01 00:00:00

  • Transforming binding affinities from three dimensions to two with application to cadherin clustering.

    abstract::Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example, the association of membrane proteins with proteins on different cells (trans-interactions) can drive the oligomerization of proteins on t...


    pub_type: 杂志文章


    authors: Wu Y,Vendome J,Shapiro L,Ben-Shaul A,Honig B

    更新日期:2011-07-27 00:00:00

  • The emergence of transcriptional identity in somatosensory neurons.

    abstract::More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess t...


    pub_type: 杂志文章


    authors: Sharma N,Flaherty K,Lezgiyeva K,Wagner DE,Klein AM,Ginty DD

    更新日期:2020-01-01 00:00:00

  • Allograft theory: transmission of devil facial-tumour disease.

    abstract::The Tasmanian devil, a large carnivorous Australian marsupial, is under threat from a widespread fatal disease in which a malignant oral-facial tumour obstructs the animal's ability to feed. Here we show that the chromosomes in these tumours have undergone a complex rearrangement that is identical for every animal stu...


    pub_type: 杂志文章


    authors: Pearse AM,Swift K

    更新日期:2006-02-02 00:00:00

  • A 'don't eat me' immune signal protects neuronal connections.

    abstract:: ...


    pub_type: 评论,新闻


    authors: Rivest S

    更新日期:2018-11-01 00:00:00

  • Myosin from fetal hearts contains the skeletal muscle embryonic light chain.

    abstract::The contractile proteins of adult skeletal and cardiac muscle tissue are very similar. Some of these proteins are identical in amino acid sequence or differ only slightly. Various structural studies have shown that the heavy and light chains of myosin are also homologous in skeletal and cardiac muscles. In developing ...


    pub_type: 杂志文章


    authors: Whalen RG,Sell SM

    更新日期:1980-08-14 00:00:00

  • A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.

    abstract::A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...


    pub_type: 杂志文章


    authors: Nguyen NUN,Canseco DC,Xiao F,Nakada Y,Li S,Lam NT,Muralidhar SA,Savla JJ,Hill JA,Le V,Zidan KA,El-Feky HW,Wang Z,Ahmed MS,Hubbi ME,Menendez-Montes I,Moon J,Ali SR,Le V,Villalobos E,Mohamed MS,Elhelaly WM,Thet

    更新日期:2020-06-01 00:00:00

  • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.

    abstract::Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggest...


    pub_type: 杂志文章


    authors: Rozakis-Adcock M,Fernley R,Wade J,Pawson T,Bowtell D

    更新日期:1993-05-06 00:00:00

  • Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.

    abstract::The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...


    pub_type: 杂志文章


    authors: Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S

    更新日期:2018-01-18 00:00:00

  • Formation of proinsulin by immobilized Bacillus subtilis.

    abstract::There has been an increasing interest in the use of immobilized cells for the production of pharmaceuticals as well as for products such as high fructose syrup or ethanol. Some of these compounds are now produced on an industrial scale whereby the cells are used in a resting or growing state or in a nonviable form as ...


    pub_type: 杂志文章


    authors: Mosbach K,Birnbaum S,Hardy K,Davies J,Bülow L

    更新日期:1983-04-07 00:00:00

  • The crystal structure of diphtheria toxin.

    abstract::The crystal structure of the diphtheria toxin dimer at 2.5 A resolution reveals a Y-shaped molecule of three domains. The catalytic domain, called fragment A, is of the alpha + beta type. Fragment B actually consists of two domains. The transmembrane domain consists of nine alpha-helices, two pairs of which are unusua...


    pub_type: 杂志文章


    authors: Choe S,Bennett MJ,Fujii G,Curmi PM,Kantardjieff KA,Collier RJ,Eisenberg D

    更新日期:1992-05-21 00:00:00

  • Glutamate-receptor-mediated encoding and retrieval of paired-associate learning.

    abstract::Paired-associate learning is often used to examine episodic memory in humans. Animal models include the recall of food-cache locations by scrub jays and sequential memory. Here we report a model in which rats encode, during successive sample trials, two paired associates (flavours of food and their spatial locations) ...


    pub_type: 杂志文章


    authors: Day M,Langston R,Morris RG

    更新日期:2003-07-10 00:00:00

  • Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene.

    abstract::Little is known about virus-host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the alphavirus genus (family Togaviridae), results in lytic infection in most vertebrate cell lines, but persistent productive...


    pub_type: 杂志文章


    authors: Levine B,Huang Q,Isaacs JT,Reed JC,Griffin DE,Hardwick JM

    更新日期:1993-02-25 00:00:00

  • Spectroscopy of short-lived radioactive molecules.

    abstract::Molecular spectroscopy offers opportunities for the exploration of the fundamental laws of nature and the search for new particle physics beyond the standard model1-4. Radioactive molecules-in which one or more of the atoms possesses a radioactive nucleus-can contain heavy and deformed nuclei, offering high sensitivit...


    pub_type: 杂志文章


    authors: Garcia Ruiz RF,Berger R,Billowes J,Binnersley CL,Bissell ML,Breier AA,Brinson AJ,Chrysalidis K,Cocolios TE,Cooper BS,Flanagan KT,Giesen TF,de Groote RP,Franchoo S,Gustafsson FP,Isaev TA,Koszorús Á,Neyens G,Perrett HA

    更新日期:2020-05-01 00:00:00