Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.

Abstract:

:The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.

journal_name

Nature

journal_title

Nature

authors

Graves BJ,Crowther RL,Chandran C,Rumberger JM,Li S,Huang KS,Presky DH,Familletti PC,Wolitzky BA,Burns DK

doi

10.1038/367532a0

subject

Has Abstract

pub_date

1994-02-10 00:00:00

pages

532-8

issue

6463

eissn

0028-0836

issn

1476-4687

journal_volume

367

pub_type

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