Abstract:
:The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.
journal_name
Naturejournal_title
Natureauthors
Graves BJ,Crowther RL,Chandran C,Rumberger JM,Li S,Huang KS,Presky DH,Familletti PC,Wolitzky BA,Burns DKdoi
10.1038/367532a0subject
Has Abstractpub_date
1994-02-10 00:00:00pages
532-8issue
6463eissn
0028-0836issn
1476-4687journal_volume
367pub_type
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