Abstract:
:The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.
journal_name
Naturejournal_title
Natureauthors
Barker RA,Götz M,Parmar Mdoi
10.1038/s41586-018-0087-1subject
Has Abstractpub_date
2018-05-01 00:00:00pages
329-334issue
7705eissn
0028-0836issn
1476-4687pii
10.1038/s41586-018-0087-1journal_volume
557pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::Cells subjected to a heat shock, or a variety of other stresses increase the synthesis of a set of proteins, known as heat shock proteins. This response is apparently universal, occurring in the entire range from bacterial to mammalian cells. In Escherichia coli heat shock protein synthesis transiently increases follo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329348a0
更新日期:1987-09-24 00:00:00
abstract::During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression1, but the gene regulatory network that co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-3027-9
更新日期:2021-01-01 00:00:00
abstract::Pyroptosis is a form of cell death that is critical for immunity. It can be induced by the canonical caspase-1 inflammasomes or by activation of caspase-4, -5 and -11 by cytosolic lipopolysaccharide. The caspases cleave gasdermin D (GSDMD) in its middle linker to release autoinhibition on its gasdermin-N domain, which...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22393
更新日期:2017-07-06 00:00:00
abstract::Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses betwee...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05395
更新日期:2007-01-18 00:00:00
abstract::The ability to design proteins with high affinity and selectivity for any given small molecule is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition. Attempts to rationally design ligand-binding proteins have met with little success, however, and the computational d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12443
更新日期:2013-09-12 00:00:00
abstract::In this Letter, the received date should have been 23 March 2017 instead of 13 April 2018. Authors R.M.K. and O.D.K. were incorrectly denoted as 'equally contributing' authors. The labels for 'control' and 'IFNγ' in Extended Data Fig. 4g were reversed. These have been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0370-1
更新日期:2018-10-01 00:00:00
abstract::Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and associated genotyping data, representing males ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10523
更新日期:2011-10-26 00:00:00
abstract::Although the regeneration of nervous tissue in the vertebrate is very limited, there are a few remarkable examples of this process. Understanding the factors that regulate CNS regeneration in those areas of the nervous system where it occurs, will doubtless provide generally applicable, essential information about the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330068a0
更新日期:1987-11-05 00:00:00
abstract::The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06239
更新日期:2007-11-29 00:00:00
abstract::Plants can have positive effects on each other. For example, the accumulation of nutrients, provision of shade, amelioration of disturbance, or protection from herbivores by some species can enhance the performance of neighbouring species. Thus the notion that the distributions and abundances of plant species are inde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00812
更新日期:2002-06-20 00:00:00
abstract::The brain cholecystokinin-B/gastrin receptor (CCK-B/gastrin) has been implicated in mediating anxiety, panic attacks, satiety, and the perception of pain. The canine and human CCK-B/gastrin receptors share 90% amino-acid identity and have similar agonist affinities. These receptors can be selectively blocked by the no...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362348a0
更新日期:1993-03-25 00:00:00
abstract::MicroRNAs (miRNAs) mediate post-transcriptional gene regulation through association with Argonaute proteins (AGOs). Crystal structures of archaeal and bacterial homologues of AGOs have shown that the MID (middle) domain mediates the interaction with the phosphorylated 5' end of the miRNA guide strand and this interact...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09039
更新日期:2010-06-10 00:00:00
abstract::We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature724
更新日期:2002-02-21 00:00:00
abstract::Rates of atmospheric deposition of biologically active nitrogen (N) are two to seven times the pre-industrial rates in many developed nations because of combustion of fossil fuels and agricultural fertilization. They are expected to increase similarly over the next 50 years in industrializing nations of Asia and South...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06503
更新日期:2008-02-07 00:00:00
abstract::Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent transcription, acting as a homodimer or as a heterodimer. Here we identify an antagonist towards RXR homodimers which also functions as an agonist when RXR is paired as a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/383450a0
更新日期:1996-10-03 00:00:00
abstract::The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326886a0
更新日期:1987-04-30 00:00:00
abstract::Growing populations and agricultural intensification have led to raised riverine nitrogen (N) loads, widespread oxygen depletion in coastal zones (coastal hypoxia)1 and increases in the incidence of algal blooms.Although recent work has suggested that individual wetlands have the potential to improve water quality2-9,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03042-5
更新日期:2020-12-01 00:00:00
abstract::The expression of immunodeficiency in patients with specific purine enzyme defects indicates a crucial role of the purine salvage pathway in the acquisition and expression of normal immune function. One current hypothesis links the failure of normal lymphocyte development in these diseases to the accumulation of deoxy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285494a0
更新日期:1980-06-12 00:00:00
abstract::DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35037509
更新日期:2000-10-12 00:00:00
abstract::Transforming viral proteins such as E1A force cells through the restriction point of the cell cycle into S phase by forming complexes with two cellular proteins: the retinoblastoma protein (Rb), a transcriptional co-repressor, and CBP/p300, a transcriptional co-activator. These two proteins locally influence chromatin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/24190
更新日期:1998-11-12 00:00:00
abstract::The dispute among federal agencies over regulation of commercial biotechnology has been addressed in the Federal Register by the Office of Science and Technology Policy (OSTP), which says the Recombinant DNA Advisory Committee of the National Institutes of Health should continue to oversee biomedical research in this ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/313085b0
更新日期:1985-01-10 00:00:00
abstract::Deltas and alluvial fans preserved on the surface of Mars provide an important record of surface water flow. Understanding how surface water flow could have produced the observed morphology is fundamental to understanding the history of water on Mars. To date, morphological studies have provided only minimum time esti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06615
更新日期:2008-02-21 00:00:00
abstract::Regulatory T (T(reg)) cells are a critical sub-population of CD4+ T cells that are essential for maintaining self tolerance and preventing autoimmunity, for limiting chronic inflammatory diseases, such as asthma and inflammatory bowel disease, and for regulating homeostatic lymphocyte expansion. However, they also sup...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06306
更新日期:2007-11-22 00:00:00
abstract::Aquifex aeolicus was one of the earliest diverging, and is one of the most thermophilic, bacteria known. It can grow on hydrogen, oxygen, carbon dioxide, and mineral salts. The complex metabolic machinery needed for A. aeolicus to function as a chemolithoautotroph (an organism which uses an inorganic carbon source for...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/32831
更新日期:1998-03-26 00:00:00
abstract::Plants cope with the environment in a variety of ways, and ecological analyses attempt to capture this through life-history strategies or trait-based categorization. These approaches are limited because they treat the trade-off mechanisms that underlie plant responses as a black box. Approaches that involve the molecu...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature22010
更新日期:2017-03-15 00:00:00
abstract::For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature07361
更新日期:2008-10-09 00:00:00
abstract::The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03845
更新日期:2005-08-11 00:00:00
abstract::In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285573a0
更新日期:1980-06-19 00:00:00
abstract::Owing to their scientific and technological importance, inorganic single crystals with highly reactive surfaces have long been studied. Unfortunately, surfaces with high reactivity usually diminish rapidly during the crystal growth process as a result of the minimization of surface energy. A typical example is titaniu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06964
更新日期:2008-05-29 00:00:00
abstract::Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333737a0
更新日期:1988-06-23 00:00:00