Abstract:
:The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis.
journal_name
Naturejournal_title
Natureauthors
Hemann MT,Bric A,Teruya-Feldstein J,Herbst A,Nilsson JA,Cordon-Cardo C,Cleveland JL,Tansey WP,Lowe SWdoi
10.1038/nature03845keywords:
subject
Has Abstractpub_date
2005-08-11 00:00:00pages
807-11issue
7052eissn
0028-0836issn
1476-4687pii
nature03845journal_volume
436pub_type
杂志文章相关文献
NATURE文献大全abstract::Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310138a0
更新日期:1984-07-12 00:00:00
abstract::Cryptochromes are blue/ultraviolet-A light receptors that mediate various light responses in plants and animals. But the initial photochemical reaction of cryptochrome is still unclear. For example, although most photoreceptors are known to undergo light-dependent protein modification such as phosphorylation, no blue-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00815
更新日期:2002-06-13 00:00:00
abstract::Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an eff...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-019-1841-8
更新日期:2019-12-01 00:00:00
abstract::Many marine invertebrates and fish respond to hydrostatic pressure in order to regulate their depth and synchronize their behaviour to tidal cycles. Here we investigate the effect of hydrostatic pressure on the vestibular hair cells located in the labyrinth of the dogfish Scyliorhinus canicula, and find that it modula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415495a
更新日期:2002-01-31 00:00:00
abstract::Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01766
更新日期:2003-07-10 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07046-0
更新日期:2018-10-01 00:00:00
abstract::An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/427802a
更新日期:2004-02-26 00:00:00
abstract::Quasicrystals are unique structures with long-range order but no periodicity. Their properties have intrigued scientists ever since their discovery and initial theoretical analysis. The lack of periodicity excludes the possibility of describing quasicrystal structures with well-established analytical tools, including ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04722
更新日期:2006-04-27 00:00:00
abstract::Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- a...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35025236
更新日期:2000-09-14 00:00:00
abstract::Sexual differences in the extent and type of parental care lie at the heart of sexual selection theory, and evolution resulting from parental conflict has produced some striking behavioural and morphological adaptations. In a study of male pregnancy in Gulf pipefish, Paczolt and Jones showed that more eggs were transf...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09275
更新日期:2010-08-26 00:00:00
abstract::Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature06156
更新日期:2007-08-23 00:00:00
abstract::The evolution of the middle ear is central to the discussion of how the first tetrapods adapted to life on land as well as their phylogeny. Here I report the discovery of the stapes of Acanthostega gunnari, from the Upper Devonian of east Greenland. This is the earliest tetrapod stapes so far described, and it throws ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342425a0
更新日期:1989-11-23 00:00:00
abstract::A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/355409a0
更新日期:1992-01-30 00:00:00
abstract::Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2388-4
更新日期:2020-06-01 00:00:00
abstract::Magnetars are neutron stars with X-ray and soft γ-ray outbursts thought to be powered by intense internal magnetic fields. Like conventional neutron stars in the form of radio pulsars, magnetars exhibit 'glitches' during which angular momentum is believed to be transferred between the solid outer crust and the superfl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12159
更新日期:2013-05-30 00:00:00
abstract::The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344068a0
更新日期:1990-03-01 00:00:00
abstract::In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent neurotrophic factor for dopamine neurons described so far is the glial...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05957
更新日期:2007-07-05 00:00:00
abstract::Lecithin is a major structural component of biological membranes. Because of their amphipathic nature, lecithin and related phospholipids tend to aggregate as bilayer structures in which the hydrophilic head groups are orientated towards the surface and the hydrophobic hydrocarbon chains towards the interior. A detail...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/281499a0
更新日期:1979-10-11 00:00:00
abstract::The germ-cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote. We have previously demonstrated that, by using cytokines, embryonic stem cells and induced pluripotent stem cells can be induced into epiblast-like cells (EpiLCs) and then in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12417
更新日期:2013-09-12 00:00:00
abstract::The medial entorhinal cortex (MEC) is part of the brain's circuit for dynamic representation of self-location. The metric of this representation is provided by grid cells, cells with spatial firing fields that tile environments in a periodic hexagonal pattern. Limited anatomical sampling has obscured whether the grid ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11649
更新日期:2012-12-06 00:00:00
abstract::Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287147a0
更新日期:1980-09-11 00:00:00
abstract::Caste differentiation and division of labour are the hallmarks of insect societies and at the root of their ecological success. Kin selection predicts that caste determination should result from environmentally induced differences in gene expression, a prediction largely supported by empirical data. However, two excep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01744
更新日期:2003-07-17 00:00:00
abstract::In nature, organisms are exposed to chronic low-dose ultraviolet light (CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA repair by the nucleotide excision repair pathway and for checkpoin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07580
更新日期:2009-01-29 00:00:00
abstract::When electrons are subject to a large external magnetic field, the conventional charge quantum Hall effect dictates that an electronic excitation gap is generated in the sample bulk, but metallic conduction is permitted at the boundary. Recent theoretical models suggest that certain bulk insulators with large spin-orb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06843
更新日期:2008-04-24 00:00:00
abstract::Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24620
更新日期:2017-11-30 00:00:00
abstract::One of us has previously reported that treatment of the Keilin and Hartree heart-muscle preparation with 2,3-dimercaptopropanol (BAL), in the presence of air, leads to the complete inactivation of the succinate oxidase system with little if any effect on the activities of succinate dehydrogenase (until more than half ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288717a0
更新日期:1980-12-25 00:00:00
abstract::T lymphocytes, essential for the generation of a normal immune response, require the presence of the lymphokine interleukin-2 (IL-2) in order to proliferate. Cells that respond to IL-2 possess a surface receptor glycoprotein specific for this lymphokine. We have recently purified and chemically characterized the IL-2 ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/312768a0
更新日期:1984-12-20 00:00:00
abstract::Planetary aurorae are formed by energetic charged particles streaming along the planet's magnetic field lines into the upper atmosphere from the surrounding space environment. Earth's main auroral oval is formed through interactions with the solar wind, whereas that at Jupiter is formed through interactions with plasm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07077
更新日期:2008-06-19 00:00:00
abstract::The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/366654a0
更新日期:1993-12-16 00:00:00
abstract::p60src, the transforming protein of Rous sarcoma virus (RSV), is a protein kinase that has a strict specificity for tyrosine. The phosphorylation of cellular proteins by p60src (ref. 4) results in transformation. Recently, Barker and Dayhoff discovered that residues 259-485 of p60src have 22% sequence identity with re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310589a0
更新日期:1984-08-16 00:00:00