Abstract：
:Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses between type II and III lines to show that strain-specific differences in the modulation of host cell transcription are mediated by a putative protein kinase, ROP16. Upon invasion by the parasite, this polymorphic protein is released from the apical organelles known as rhoptries and injected into the host cell, where it ultimately affects the activation of signal transducer and activator of transcription (STAT) signalling pathways and consequent downstream effects on a key host cytokine, interleukin (IL)-12. Our findings provide a new mechanism for how an intracellular eukaryotic pathogen can interact with its host and reveal important differences in how different Toxoplasma lineages have evolved to exploit this interaction.
journal_name
Naturejournal_title
Natureauthors
Saeij JP,Coller S,Boyle JP,Jerome ME,White MW,Boothroyd JCdoi
10.1038/nature05395subject
Has Abstractpub_date
2007-01-18 00:00:00pages
324-7issue
7125eissn
0028-0836issn
1476-4687pii
nature05395journal_volume
445pub_type
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