Abstract:
:During attempts to select nonsecretory variants from 0.467.3, and Epstein-Barr virus-transformed human lymphoblastoid cell line that secretes small amounts of IgM lambda, we exposed the cells to UV light. Cells that survived the irradiation were subcultured and their supernatants were screened for immunoglobulin production by an enzyme-linked immunosorbent assay (ELISA). Although stable nonsecretory variants were not isolated, we report here that an immunoglobulin class switch occurred in the UV-treated cell population. All survivors were found to produce large quantities of IgG lambda. Some cell cultures also produced the original IgM lambda. The UV-light-induced class switch was regularly reproducible with this target cell line.
journal_name
Naturejournal_title
Natureauthors
Rosén A,Klein Gdoi
10.1038/306189a0subject
Has Abstractpub_date
1983-11-10 00:00:00pages
189-90issue
5939eissn
0028-0836issn
1476-4687journal_volume
306pub_type
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