Abstract:
:Variation in ways in which proteins can identify and lock on to genes due for transcription is illuminated by studies of the Arc repressor, which has a beta-sheet, rather than alpha-helical, recognition motif.
journal_name
Naturejournal_title
Natureauthors
Riddihough Gdoi
10.1038/368082a0subject
Has Abstractpub_date
1994-03-03 00:00:00pages
82issue
6466eissn
0028-0836issn
1476-4687journal_volume
368pub_type
杂志文章相关文献
NATURE文献大全abstract::It is well established that the osteoclast is formed by fusion of post-mitotic, mononuclear precursors derived from circulating progenitor cells. However, the precise haematopoietic origin of the osteoclast is unknown. We have investigated this here by fractionating mouse bone marrow and isolating haematopoietic stem ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321079a0
更新日期:1986-05-01 00:00:00
abstract::Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35003242
更新日期:2000-01-13 00:00:00
abstract::When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289810a0
更新日期:1981-02-26 00:00:00
abstract::The existence in the ocean of deep western boundary currents, which connect the high-latitude regions where deep water is formed with upwelling regions as part of the global ocean circulation, was postulated more than 40 years ago. These ocean currents have been found adjacent to the continental slopes of all ocean ba...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03134
更新日期:2004-12-23 00:00:00
abstract::The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05042
更新日期:2006-08-24 00:00:00
abstract::The discovery of four new Xenoturbella species from deep waters of the eastern Pacific Ocean is reported here. The genus and two nominal species were described from the west coast of Sweden, but their taxonomic placement remains unstable. Limited evidence placed Xenoturbella with molluscs, but the tissues can be conta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16545
更新日期:2016-02-04 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder which affects approximately 1 in 3,300 males, making it the most common of the neuromuscular dystrophies. The biochemical basis of the disease is unknown and as yet no effective treatment is available. A small number of females are also affected with ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318672a0
更新日期:1985-12-19 00:00:00
abstract::Capacitors are a mainstay of electronic integrated circuits and devices, where they perform essential functions such as storing electrical charge, and blocking direct current while allowing alternating currents to propagate. Because they are often the largest components in circuits, extensive efforts are directed at r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05148
更新日期:2006-10-12 00:00:00
abstract::Modern agriculture has accelerated biological methane and nitrogen cycling on a global scale. Freshwater sediments often receive increased downward fluxes of nitrate from agricultural runoff and upward fluxes of methane generated by anaerobic decomposition. In theory, prokaryotes should be capable of using nitrate to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04617
更新日期:2006-04-13 00:00:00
abstract::Exploring visual illusions reveals fundamental principles of cortical processing. Illusory motion perception of non-moving stimuli was described almost a century ago by Gestalt psychologists. However, the underlying neuronal mechanisms remain unknown. To explore cortical mechanisms underlying the 'line-motion' illusio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02396
更新日期:2004-03-25 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are curre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2575-3
更新日期:2020-09-01 00:00:00
abstract::During cell division, remodelling of the nuclear envelope enables chromosome segregation by the mitotic spindle1. The reformation of sealed nuclei requires ESCRTs (endosomal sorting complexes required for transport) and LEM2, a transmembrane ESCRT adaptor2-4. Here we show how the ability of LEM2 to condense on microtu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2232-x
更新日期:2020-06-01 00:00:00
abstract::The uranyl ion (UO22+; U(VI) oxidation state) is the most common form of uranium found in terrestrial and aquatic environments and is a central component in nuclear fuel processing and waste remediation efforts. Uranyl capture from either seawater or nuclear waste has been well studied and typically relies on extremel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1926-4
更新日期:2020-01-01 00:00:00
abstract::Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. Recent molecular genetic studies have indicated that amyl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331528a0
更新日期:1988-02-11 00:00:00
abstract::A fundamental tenet of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles. Although several exceptions to this principle are known, all represent specialized cases that are mechanistically rest...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03380
更新日期:2005-03-24 00:00:00
abstract::The embryos and larvae of stalked crinoids, which are considered the most basal group of extant echinoderms, have not previously been described. In contrast, much is known about the development of the more accessible stalkless crinoids (feather stars), which are phylogenetically derived from stalked forms. Here we des...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01236
更新日期:2003-01-09 00:00:00
abstract::An increase in free calcium triggers catecholamine secretion from chromaffin cells and calmodulin is strongly implicated as the intracellular Ca2+ receptor. In our recent studies of calmodulin action in the chromaffin cell, micromolar Ca2+ concentrations resulted in calmodulin and cytosolic proteins becoming bound to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301432a0
更新日期:1983-02-03 00:00:00
abstract::Muscle force is generated by myosin crossbridges interacting with actin. As estimated from stiffness and equatorial X-ray diffraction of muscle and muscle fibres, most myosin crossbridges are attached to actin during isometric contraction, but a much smaller fraction is bound stereospecifically. To determine the fract...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40651
更新日期:1997-07-10 00:00:00
abstract::Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35101621
更新日期:2001-10-25 00:00:00
abstract::Dynamic access to genetic information is central to organismal development and environmental response. Consequently, genomic processes must be regulated by mechanisms that alter genome function relatively rapidly. Conventional chromatin immunoprecipitation (ChIP) experiments measure transcription factor occupancy, but...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10985
更新日期:2012-04-11 00:00:00
abstract::The "Gardner hypothesis" suggests that an excess of childhood leukaemia near a nuclear reprocessing plant is caused by paternal exposure to ionizing radiation. But the evidence shows that this explanation is wrong. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/367678a0
更新日期:1994-02-24 00:00:00
abstract::A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352301a0
更新日期:1991-07-25 00:00:00
abstract::The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1917-5
更新日期:2020-01-01 00:00:00
abstract::The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11092
更新日期:2012-05-30 00:00:00
abstract::Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/371717a0
更新日期:1994-10-20 00:00:00
abstract::Non-impulsive seismic radiation or 'tremor' has long been observed at volcanoes and more recently around subduction zones. Although the number of observations of non-volcanic tremor is steadily increasing, the causative mechanism remains unclear. Some have attributed non-volcanic tremor to the movement of fluids, whil...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06017
更新日期:2007-08-02 00:00:00
abstract::Rapid warming over the past 50 years on the Antarctic Peninsula is associated with the collapse of a number of ice shelves and accelerating glacier mass loss. In contrast, warming has been comparatively modest over West Antarctica and significant changes have not been observed over most of East Antarctica, suggesting ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11391
更新日期:2012-09-06 00:00:00
abstract::Geochemical and sedimentological evidence suggest that the rapid climate warming oscillations of the last ice age, the Dansgaard-Oeschger cycles, were coupled to fluctuations in North Atlantic meridional overturning circulation through its regulation of poleward heat flux. The balance between cold meltwater from the n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05121
更新日期:2006-10-05 00:00:00
abstract::During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14561
更新日期:2015-06-25 00:00:00
abstract::Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329599a0
更新日期:1987-10-15 00:00:00