Microbiome: A bag of surprises.

abstract：:Observations of galaxies and primordial radiation suggest that the Universe is made mostly of non-luminous dark matter1,2. Several new types of fundamental particle have been proposed as candidates for dark matter3, such as weakly interacting massive particles (WIMPs)4,5. These particles would be expected to interact ...

journal_title：Nature

authors： COSINE-100 Collaboration.

更新日期：2018-12-01 00:00:00

abstract：:Monocular lid suture during the sensitive period early in the life of a kitten disrupts normal development of inputs from the two eyes to the visual cortex, causing a decrease in the fraction of cortical cells responding to the deprived eye. Such an ocular dominance shift has been assumed to depend on patterned visual...

journal_title：Nature

authors： Chapman B,Jacobson MD,Reiter HO,Stryker MP

更新日期：1986-11-13 00:00:00

abstract：:A single base-pair mutation (beta s) in codon 6 of the human beta-globin gene, causing a single amino-acid substitution, is the cause of sickle cell anaemia. The mutant haemoglobin molecule, HbS, polymerizes when deoxygenated and causes deformation of the erythrocytes to a characteristic 'sickled' shape. Sickling of c...

journal_title：Nature

authors： Greaves DR,Fraser P,Vidal MA,Hedges MJ,Ropers D,Luzzatto L,Grosveld F

更新日期：1990-01-11 00:00:00

abstract：:Surgical sectioning of the corpus callosum in epileptic patients has provided a unique opportunity to study separately the competence and processing capacities of the two cerebral hemispheres, each of which is able to perceive, think, memorize and learn independently and essentially outside the realm of awareness of t...

journal_title：Nature

authors： Sergent J

更新日期：1983-10-27 00:00:00

abstract：:The detection of horizontal disparities between the right and left retinal images is accepted as an important component in the visual perception of depth. It has occasionally been pointed out that a disparity will also occur in the vertical when a target is nearer to one eye than the other and could be used as a secon...

journal_title：Nature

authors： Westheimer G

更新日期：1984-02-16 00:00:00

abstract：:Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by difficulties in re...

journal_title：Nature

authors： Calvano SE,Xiao W,Richards DR,Felciano RM,Baker HV,Cho RJ,Chen RO,Brownstein BH,Cobb JP,Tschoeke SK,Miller-Graziano C,Moldawer LL,Mindrinos MN,Davis RW,Tompkins RG,Lowry SF,Inflamm and Host Response to Injury Large Scale

更新日期：2005-10-13 00:00:00

abstract：:Thomas et al. argue, contrary to Sala et al. that climate change poses an equal or greater threat to global biodiversity than land-use change. We contest this claim, however, on the grounds that Thomas et al. incorrectly apply species-area relationships. ...

journal_title：Nature

authors： Buckley LB,Roughgarden J

更新日期：2004-07-01 00:00:00

abstract：:Mammalian neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspartate (NMDA) or aspartate, (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate. An important aspect of NMDA receptors is their regulation by a variety of factors such...

journal_title：Nature

authors： Traynelis SF,Cull-Candy SG

更新日期：1990-05-24 00:00:00

abstract：:Limiting the increase of CO2 in the atmosphere is one of the largest challenges of our generation1. Because carbon capture and storage is one of the few viable technologies that can mitigate current CO2 emissions2, much effort is focused on developing solid adsorbents that can efficiently capture CO2 from flue gases e...

journal_title：Nature

authors： Boyd PG,Chidambaram A,García-Díez E,Ireland CP,Daff TD,Bounds R,Gładysiak A,Schouwink P,Moosavi SM,Maroto-Valer MM,Reimer JA,Navarro JAR,Woo TK,Garcia S,Stylianou KC,Smit B

更新日期：2019-12-01 00:00:00

abstract：:The reliable detection of single quantum particles has revolutionized the field of quantum optics and quantum information processing. For several years, researchers have aspired to extend such detection possibilities to larger-scale, strongly correlated quantum systems in order to record in situ images of a quantum fl...

journal_title：Nature

authors： Sherson JF,Weitenberg C,Endres M,Cheneau M,Bloch I,Kuhr S

更新日期：2010-09-02 00:00:00

abstract：:Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comp...

journal_title：Nature

authors： Ko K,Araúzo-Bravo MJ,Tapia N,Kim J,Lin Q,Bernemann C,Han DW,Gentile L,Reinhardt P,Greber B,Schneider RK,Kliesch S,Zenke M,Schöler HR

更新日期：2010-06-24 00:00:00

abstract：:Humans have engaged in endurance running for millions of years, but the modern running shoe was not invented until the 1970s. For most of human evolutionary history, runners were either barefoot or wore minimal footwear such as sandals or moccasins with smaller heels and little cushioning relative to modern running sh...

journal_title：Nature

authors： Lieberman DE,Venkadesan M,Werbel WA,Daoud AI,D'Andrea S,Davis IS,Mang'eni RO,Pitsiladis Y

更新日期：2010-01-28 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) is a mitogenically active polypeptide hormone produced by acutely proliferating neoplastic and embryonic tissues. Molecular cloning of TGF-alpha cDNA from human and rat has indicated that this factor is synthesized as part of a larger precursor, proTGF-alpha. An intriguing ...

journal_title：Nature

authors： Teixidó J,Gilmore R,Lee DC,Massagué J

更新日期：1987-04-30 00:00:00

abstract：:A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is co...

journal_title：Nature

authors： Amos LA,Baker TS

更新日期：1979-06-14 00:00:00

abstract：:The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result...

journal_title：Nature

authors： Santoro C,Mermod N,Andrews PC,Tjian R

更新日期：1988-07-21 00:00:00

abstract：:Elucidation of the nature of the gene interactions that underly the sterility of interspecific hybrids is important in evolutionary biology. The interactions between the heterospecific X and Y (or Z and W) chromosomes are often used as an explanation for two reasons. First, the fertility of the hybrids of the heteroga...

journal_title：Nature

authors： Johnson NA,Perez DE,Cabot EL,Hollocher H,Wu CI

更新日期：1992-08-27 00:00:00

abstract：:Temperature-dependent transition of conductance in ionic channels has been described in several membrane systems. We report here an abrupt change in the maximal rate of rise of the action potentials of the rat extensor digitorum longus (EDL) at 32 degrees C, indicating alteration in the functional characteristics of t...

journal_title：Nature

authors： Cheung DW,Daniel EE

更新日期：1980-01-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： DeRocher KA,Smeets PJM,Goodge BH,Zachman MJ,Balachandran PV,Stegbauer L,Cohen MJ,Gordon LM,Rondinelli JM,Kourkoutis LF,Joester D

更新日期：2020-08-01 00:00:00

abstract：:T-cell factor (TCF), a high-mobility-group domain protein, is the transcription factor activated by Wnt/Wingless signalling. When signalling occurs, TCF binds to its coactivator, beta-catenin/Armadillo, and stimulates the transcription of the target genes of Wnt/Wingless by binding to TCF-responsive enhancers. Inappro...

journal_title：Nature

authors： Waltzer L,Bienz M

更新日期：1998-10-01 00:00:00

abstract：:In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...

journal_title：Nature

authors： Haase SB,Reed SI

更新日期：1999-09-23 00:00:00

abstract：:Protein design provides a rigorous test of our knowledge about proteins and allows the creation of novel enzymes for biotechnological applications. Whereas progress has been made in designing proteins that mimic native proteins structurally, it is more difficult to design functional proteins. In comparison to recent s...

journal_title：Nature

authors： Yeung N,Lin YW,Gao YG,Zhao X,Russell BS,Lei L,Miner KD,Robinson H,Lu Y

更新日期：2009-12-24 00:00:00

abstract：:In contrast to microRNAs and Piwi-associated RNAs, short interfering RNAs (siRNAs) are seemingly dispensable for host-directed gene regulation in Drosophila. This notion is based on the fact that mutants lacking the core siRNA-generating enzyme Dicer-2 or the predominant siRNA effector Argonaute 2 are viable, fertile ...

journal_title：Nature

authors： Okamura K,Chung WJ,Ruby JG,Guo H,Bartel DP,Lai EC

更新日期：2008-06-05 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:The tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents. As p53 is a transcriptional activator that mediates gene induction after DNA damage, it has been proposed to be a genetic switch that activates apoptosis-mediator genes. Here we evaluate the role of p53 in DNA-dam...

journal_title：Nature

authors： Caelles C,Helmberg A,Karin M

更新日期：1994-07-21 00:00:00

abstract：:Recognition of objects or environmental landmarks is problematic because appearance can vary widely depending on illumination, viewing distance, angle of view and so on. Storing a separate image or 'template' for every possible view requires vast numbers to be stored and scanned, has a high probability of recognition ...

journal_title：Nature

authors： Dawkins MS,Woodington A

更新日期：2000-02-10 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:The mouse major transplantation antigens H-2K, H-2D and H-2L are highly polymorphic cell-surface glycoproteins which may serve as recognition elements in cell-cell interactions. Each antigen possesses a number of alloantigenic determinants defined by antisera of various specificities. Recently, monoclonal antibodies h...

journal_title：Nature

authors： Evans GA,Margulies DH,Shykind B,Seidman JG,Ozato K

更新日期：1982-12-23 00:00:00

abstract：:Nerve growth factor (NGF) activity was not detected by bioassay in irides killed immediately after excision but NGF appeared within 24 h in living irides placed in culture or grafted to a host eye. Furthermore, sensory and, although less effective, sympathetic denervation of irides in situ led within 10 days to the ap...

journal_title：Nature

authors： Ebendal T,Olson L,Seiger A,Hedlund KO

更新日期：1980-07-03 00:00:00

abstract：:Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge...

journal_title：Nature

authors： Kaiser TS,Poehn B,Szkiba D,Preussner M,Sedlazeck FJ,Zrim A,Neumann T,Nguyen LT,Betancourt AJ,Hummel T,Vogel H,Dorner S,Heyd F,von Haeseler A,Tessmar-Raible K

更新日期：2016-12-01 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00