Abstract：
:Monocular lid suture during the sensitive period early in the life of a kitten disrupts normal development of inputs from the two eyes to the visual cortex, causing a decrease in the fraction of cortical cells responding to the deprived eye. Such an ocular dominance shift has been assumed to depend on patterned visual experience, because no change in cortical physiology is produced by inequalities between the two eyes in retinal illumination or temporally modulated diffuse light stimulation. A higher-level process, involving gating signals from areas outside striate cortex, has been proposed to ensure that sustained changes in synaptic efficacy occur only in response to behaviourally significant visual inputs. To test whether such a process is necessary for ocular dominance plasticity, we treated 4-week-old kittens with visual deprivation and monocular tetrodotoxin (TTX) injections to create an imbalance in the electrical activities of the two retinas in the absence of patterned vision. After 1 week of treatment we determined the ocular dominance distribution of single units in primary visual cortex. In all kittens studied, a significant ocular dominance shift was found. In addition to this physiological change, there was an anatomical change in the lateral geniculate nucleus, where cells were larger in laminae receiving input from the more active eye. Our results indicate that patterned vision is not necessary for visual cortical plasticity, and that an imbalance in spontaneous retinal activity alone can produce a significant ocular dominance shift.
journal_name
Naturejournal_title
Natureauthors
Chapman B,Jacobson MD,Reiter HO,Stryker MPdoi
10.1038/324154a0subject
Has Abstractpub_date
1986-11-13 00:00:00pages
154-6issue
6093eissn
0028-0836issn
1476-4687journal_volume
324pub_type
杂志文章相关文献
NATURE文献大全abstract：:The origins of religion and of complex societies represent evolutionary puzzles1-8. The 'moralizing gods' hypothesis offers a solution to both puzzles by proposing that belief in morally concerned supernatural agents culturally evolved to facilitate cooperation among strangers in large-scale societies9-13. Although pr...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/s41586-019-1043-4
更新日期：2019-04-01 00:00:00
abstract：:The observation that a few species in ecological communities are exceptionally abundant, whereas most are rare, prompted the development of species abundance models. Nevertheless, despite the large literature on the commonness and rarity of species inspired by these pioneering studies, some widespread empirical patter...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01547
更新日期：2003-04-17 00:00:00
abstract：:Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known as TP53) influences a range of cellular metabolic processes, including glycolysis, oxidative phosphorylation, glutamino...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11743
更新日期：2013-01-24 00:00:00
abstract：:Fungi are the principal degraders of biomass in terrestrial ecosystems and establish important interactions with plants and animals. However, our current understanding of fungal evolutionary diversity is incomplete and is based upon species amenable to growth in culture. These culturable fungi are typically yeast or f...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09984
更新日期：2011-05-11 00:00:00
abstract：:The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09278
更新日期：2010-08-05 00:00:00
abstract：:Information--be it classical or quantum--is measured by the amount of communication needed to convey it. In the classical case, if the receiver has some prior information about the messages being conveyed, less communication is needed. Here we explore the concept of prior quantum information: given an unknown quantum ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03909
更新日期：2005-08-04 00:00:00
abstract：:Neptune has five narrow ring arcs, spanning about 40 degrees in longitude, which are apparently confined against the rapid azimuthal and radial spreading that normally results from inter-particle collisions. A gravitational resonance based on the vertical motion of the nearby neptunian moon Galatea was proposed to exp...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417045a
更新日期：2002-05-02 00:00:00
abstract：:During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature09228
更新日期：2010-06-10 00:00:00
abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417087a
更新日期：2002-05-02 00:00:00
abstract：:Leks have traditionally been considered as arenas where males compete to attract females and secure matings. Thus, direct fitness benefits mediated through competition between males to fertilize females have been considered to be the primary force driving the evolution of lekking behaviour. Inclusive fitness benefits ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35042562
更新日期：2000-11-16 00:00:00
abstract：:This corrects the article DOI: 10.1038/nature21725. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/nature23659
更新日期：2017-08-31 00:00:00
abstract：:Secretory-protein translocation into the endoplasmic reticulum (ER) is thought to be catalysed by integral membrane proteins. Genetic selections uncovered three Saccharomyces cerevisiae genes (SEC61, SEC62 and SEC63), mutations in which block import of precursor proteins into the ER lumen in vivo and in vitro. The DNA...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/349806a0
更新日期：1991-02-28 00:00:00
abstract：:Control of protein synthesis is associated with changes in the ratio of intracellular Na+ to K+ in the cultured embryonic chick lens. Correlations of intracellular Na+/K+ ratios with crystallin synthesis and cataract formation in vitro suggest that the Na+/K+ ratio may have an important role in the regulation of prote...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/270406a0
更新日期：1977-12-01 00:00:00
abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10382
更新日期：2011-09-04 00:00:00
abstract：:Transposable elements of DNA that are structurally defined and genetically discrete units seem to have an important role in the evolution of bacterial plasmids. Recombination occurring at the termini of such elements can result in the joining together of unrelated DNA segments that lack extensive nucleotide sequence h...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/263731a0
更新日期：1976-10-28 00:00:00
abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35081193
更新日期：2001-06-14 00:00:00
abstract：:The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35015572
更新日期：2000-06-15 00:00:00
abstract：:Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constituti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/23738
更新日期：1999-08-26 00:00:00
abstract：:Multicomponent reactions are relied on in both academic and industrial synthetic organic chemistry owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2060-z
更新日期：2020-04-01 00:00:00
abstract：:There have been many reports that eukaryotic cells contain ring-shaped 19S or 20S particles which are composed of numerous polypeptide subunits ranging in size between 25 and 35 kilodaltons. Because these particles seemed to copurify with inactive mRNA, they were assumed to function in regulating mRNA translation and ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/331192a0
更新日期：1988-01-14 00:00:00
abstract：:Observations from Earth-orbiting satellites have been a key component in monitoring climate change for the past two decades. This has become possible with the availability of air temperatures from the Microwave Sounding Unit (MSU) since 1979, sea surface temperatures from the Advanced Very High Resolution Radiometer (...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35000184
更新日期：2000-01-27 00:00:00
abstract：:Excitatory amino acids (EAAs) are important neurotransmitters in the vertebrate central nervous system. Electrophysiological and ligand-binding studies indicate that at least three different receptor subtypes for EAAs exist--N-methyl-D-aspartate, kainate and quisqualate receptor subtypes--on the basis of the preferred...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/342684a0
更新日期：1989-12-07 00:00:00
abstract：:A popular metaphor for the representation of numbers in the brain is the 'mental number line', in which numbers are represented in a continuous, quantity-based analogical format. Here we show that patients with hemispatial neglect misplace the midpoint of a numerical interval when asked to bisect it (for example, stat...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417138a
更新日期：2002-05-09 00:00:00
abstract：:Sodium channels in plasma membranes can be blocked by a large variety of toxins and local anaesthetics. This property, however, is not confined to relatively large molecules. For instance, extracellularly applied small ions like hydrogen may also prevent the passive transport of permeant cations across open Na+ channe...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/287062a0
更新日期：1980-09-04 00:00:00
abstract：:The proton-activated chloride channel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell death and tissue injury1-3. PAC has recently been shown to represent a novel and evolutionarily conserved protein family4,5. Here we present two cryo-electron microscopy structures of human...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2875-7
更新日期：2020-12-01 00:00:00
abstract：:Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding of gene function in the post-genomic era. Proteomics can be divided into three main areas: (1) protein micro-characterization for large-scale identification of proteins and their post-translational modifications; (2) 'differ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/35015709
更新日期：2000-06-15 00:00:00
abstract：:The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/347776a0
更新日期：1990-10-25 00:00:00
abstract：:Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35050141
更新日期：2000-12-21 00:00:00
abstract：:Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11661
更新日期：2013-01-10 00:00:00
abstract：:Framework cavities are the largest but least explored coral reef habitat. Previous dive studies of caverns, spaces below plate corals, rubble and artificial cavities suggest that cavity-dwelling (coelobite) filter-feeders are important in the trophodynamics of reefs. Quantitative community data are lacking, however, a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35099547
更新日期：2001-10-18 00:00:00
