Abstract:
:Temperature-dependent transition of conductance in ionic channels has been described in several membrane systems. We report here an abrupt change in the maximal rate of rise of the action potentials of the rat extensor digitorum longus (EDL) at 32 degrees C, indicating alteration in the functional characteristics of the sodium channels. Tetrodotoxin (TTX) and imidazole were used to investigate further the change in properties of the sodium channels with respect to temperature. TTX is known for its specificity in blocking sodium channels. It has been proposed that the guanidinium group of the TTX molecule is essential for its activity. Other guanidinium compounds have also been shown to be effective in blocking the sodium channels. In this study, imidazole, a compound structurally similar to guanidine, was also tested. We find that TTX and imidazole affect the maximal rate of rise of the action potential in a temperature-dependent manner.
journal_name
Naturejournal_title
Natureauthors
Cheung DW,Daniel EEdoi
10.1038/283485a0subject
Has Abstractpub_date
1980-01-31 00:00:00pages
485-6issue
5746eissn
0028-0836issn
1476-4687journal_volume
283pub_type
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