Abstract:
:Fusion of biological membranes is mediated by specific lipid-interacting proteins that induce the formation and expansion of an initial fusion pore. Here we report the crystal structure of the ectodomain of the Semliki Forest virus fusion glycoprotein E1 in its low-pH-induced trimeric form. E1 adopts a folded-back conformation that, in the final post-fusion form of the full-length protein, would bring the fusion peptide loop and the transmembrane anchor to the same end of a stable protein rod. The observed conformation of the fusion peptide loop is compatible with interactions only with the outer leaflet of the lipid bilayer. Crystal contacts between fusion peptide loops of adjacent E1 trimers, together with electron microscopy observations, suggest that in an early step of membrane fusion, an intermediate assembly of five trimers creates two opposing nipple-like deformations in the viral and target membranes, leading to formation of the fusion pore.
journal_name
Naturejournal_title
Natureauthors
Gibbons DL,Vaney MC,Roussel A,Vigouroux A,Reilly B,Lepault J,Kielian M,Rey FAdoi
10.1038/nature02239keywords:
subject
Has Abstractpub_date
2004-01-22 00:00:00pages
320-5issue
6972eissn
0028-0836issn
1476-4687pii
nature02239journal_volume
427pub_type
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