Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.

abstract：:In Extended Data Fig. 5d of this Letter, the blots for anti-pS612 and anti-BAK1 were inadvertently duplicated. This figure has been corrected online. ...

journal_title：Nature

authors： Perraki A,DeFalco TA,Derbyshire P,Avila J,Séré D,Sklenar J,Qi X,Stransfeld L,Schwessinger B,Kadota Y,Macho AP,Jiang S,Couto D,Torii KU,Menke FLH,Zipfel C

更新日期：2018-11-01 00:00:00

abstract：:The cyanobacterium Prochlorococcus is the dominant oxygenic phototroph in the tropical and subtropical regions of the world's oceans. It can grow at a range of depths over which light intensities can vary by up to 4 orders of magnitude. This broad depth distribution has been hypothesized to stem from the coexistence o...

journal_title：Nature

authors： Moore LR,Rocap G,Chisholm SW

更新日期：1998-06-04 00:00:00

abstract：:After host entry through mucosal surfaces, human immunodeficiency virus-1 (HIV-1) disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally during the early stages of transmission and systemically during ...

journal_title：Nature

authors： Murooka TT,Deruaz M,Marangoni F,Vrbanac VD,Seung E,von Andrian UH,Tager AM,Luster AD,Mempel TR

更新日期：2012-10-11 00:00:00

abstract：:Regulation of transcription initiation by proteins binding at DNA sequences some distance from the promoter region itself seems to be a general phenomenon in both eukaryotes and prokaryotes. Proteins bound to an enhancer site in eukaryotes can turn on a distant gene, whereas efficient repression of some prokaryotic ge...

journal_title：Nature

authors： Dandanell G,Valentin-Hansen P,Larsen JE,Hammer K

更新日期：1987-02-26 00:00:00

abstract：:A type Ia supernova is thought to be a thermonuclear explosion of either a single carbon-oxygen white dwarf or a pair of merging white dwarfs. The explosion fuses a large amount of radioactive (56)Ni (refs 1-3). After the explosion, the decay chain from (56)Ni to (56)Co to (56)Fe generates γ-ray photons, which are rep...

journal_title：Nature

authors： Churazov E,Sunyaev R,Isern J,Knödlseder J,Jean P,Lebrun F,Chugai N,Grebenev S,Bravo E,Sazonov S,Renaud M

更新日期：2014-08-28 00:00:00

abstract：:Anti-cancer agents that have been made selective for tumour cells by exploiting the known differences in the availability of oxygen between normal and transformed cells are a promising development in cancer chemotherapy. We have recently suggested a new type of bioreductive activity which would depend on a two-electro...

journal_title：Nature

authors： Reynolds CA,King PM,Richards WG

更新日期：1988-07-07 00:00:00

abstract：:It is thought that in skeletal muscle excitation-contraction (EC) coupling, the release of Ca2+ from the sarcoplasmic reticulum is controlled by the dihydropyridine (DHP) receptor in the transverse tubular membrane, where it serves as the voltage sensor. We have shown previously that injection of an expression plasmid...

journal_title：Nature

authors： Tanabe T,Beam KG,Adams BA,Niidome T,Numa S

更新日期：1990-08-09 00:00:00

abstract：:What is it that defines an animal? The definition provided here, made on the basis of developmental biology, suggests methods for resolving phylogenetic problems. ...

journal_title：Nature

authors： Slack JM,Holland PW,Graham CF

更新日期：1993-02-11 00:00:00

abstract：:The 18-base-pair sequence element AGGTCGACCAGTACTCCG (the Sal box) signals termination of mouse ribosomal gene transcription. This sequence is recognized by a sequence-specific DNA-binding protein, TTF I, which mediates the termination of transcription by RNA polymerase I (pol I). Subsequently, the ends of the primary...

journal_title：Nature

authors： Kuhn A,Bartsch I,Grummt I

更新日期：1990-04-05 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...

journal_title：Nature

authors： Lovley DR,Woodward JC,Chapelle FH

更新日期：1994-07-14 00:00:00

abstract：:Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could res...

journal_title：Nature

authors： Toth PT,Bindokas VP,Bleakman D,Colmers WF,Miller RJ

更新日期：1993-08-12 00:00:00

abstract：:In the Caenorhabditis elegans hermaphrodite germ line, sperm and then oocytes are made from a common pool of germ-cell precursors. The decision to differentiate as a sperm or an oocyte is regulated by the sex-determining gene, fem-3. Expression of fem-3 in the hermaphrodite germ line directs spermatogenesis and must b...

journal_title：Nature

authors： Ahringer J,Kimble J

更新日期：1991-01-24 00:00:00

abstract：:Regulatory T cells (Treg cells), a distinct subset of CD4+ T cells, are necessary for the maintenance of immune self-tolerance and homeostasis1,2. Recent studies have demonstrated that Treg cells exhibit a unique metabolic profile, characterized by an increase in mitochondrial metabolism relative to other CD4+ effecto...

journal_title：Nature

authors： Weinberg SE,Singer BD,Steinert EM,Martinez CA,Mehta MM,Martínez-Reyes I,Gao P,Helmin KA,Abdala-Valencia H,Sena LA,Schumacker PT,Turka LA,Chandel NS

更新日期：2019-01-01 00:00:00

abstract：:Wolbachia is a common maternally inherited bacterial symbiont able to induce crossing sterilities known as cytoplasmic incompatibility (CI) in insects. Wolbachia-modified sperm are unable to complete fertilization of uninfected ova, but a rescue function allows infected eggs to develop normally. By providing a reprodu...

journal_title：Nature

authors： Sinkins SP,Walker T,Lynd AR,Steven AR,Makepeace BL,Godfray HC,Parkhill J

更新日期：2005-07-14 00:00:00

abstract：:The regulation of intracellular pH (pHi) is essential for normal cell function, and controlled changes in pHi may play a central role in cell activation. Sodium-dependent Cl-HCO3 exchange is the dominant mechanism of pHi regulation in the invertebrate cells examined, and also occurs in mammalian cells. The transporter...

journal_title：Nature

authors： Boron WF,Hogan E,Russell JM

更新日期：1988-03-17 00:00:00

abstract：:Genomes from all of the crucial bacterial pathogens of humans, plants and animals have now been sequenced, as have genomes from many of the important commensal, symbiotic and environmental microorganisms. Analysis of these sequences has revealed the forces that shape pathogen evolution and has brought to light unexpec...

journal_title：Nature

authors： Pallen MJ,Wren BW

更新日期：2007-10-18 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Narayan A

更新日期：2019-03-01 00:00:00

abstract：:Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...

journal_title：Nature

authors： de Vries JE,Mendelsohn J,Bont WS

更新日期：1980-02-07 00:00:00

abstract：:The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

journal_title：Nature

authors： Gros P,Ben Neriah YB,Croop JM,Housman DE

更新日期：1986-10-23 00:00:00

abstract：:Uridine at the first anticodon position (U34) of glutamate, lysine and glutamine transfer RNAs is universally modified by thiouridylase into 2-thiouridine (s2U34), which is crucial for precise translation by restricting codon-anticodon wobble during protein synthesis on the ribosome. However, it remains unclear how th...

journal_title：Nature

authors： Numata T,Ikeuchi Y,Fukai S,Suzuki T,Nureki O

更新日期：2006-07-27 00:00:00

abstract：:Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal t...

journal_title：Nature

authors： Wiesner T,Lee W,Obenauf AC,Ran L,Murali R,Zhang QF,Wong EW,Hu W,Scott SN,Shah RH,Landa I,Button J,Lailler N,Sboner A,Gao D,Murphy DA,Cao Z,Shukla S,Hollmann TJ,Wang L,Borsu L,Merghoub T,Schwartz GK,Postow MA

更新日期：2015-10-15 00:00:00

abstract：:Haemoglobin is the prototype of an allosteric protein in which cooperative behaviour depends on interaction between unlike subunits. Here we present haematological and biochemical evidence that electrostatic interactions are an important determinant of haemoglobin assembly. Individuals heterozygous for positively char...

journal_title：Nature

authors： Bunn HF,McDonald MJ

更新日期：1983-12-01 00:00:00

abstract：:Electronic devices have advanced from their heavy, bulky origins to become smart, mobile appliances. Nevertheless, they remain rigid, which precludes their intimate integration into everyday life. Flexible, textile and stretchable electronics are emerging research areas and may yield mainstream technologies. Rollable ...

journal_title：Nature

authors： Kaltenbrunner M,Sekitani T,Reeder J,Yokota T,Kuribara K,Tokuhara T,Drack M,Schwödiauer R,Graz I,Bauer-Gogonea S,Bauer S,Someya T

更新日期：2013-07-25 00:00:00

abstract：:53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...

journal_title：Nature

authors： Ghezraoui H,Oliveira C,Becker JR,Bilham K,Moralli D,Anzilotti C,Fischer R,Deobagkar-Lele M,Sanchiz-Calvo M,Fueyo-Marcos E,Bonham S,Kessler BM,Rottenberg S,Cornall RJ,Green CM,Chapman JR

更新日期：2018-08-01 00:00:00

abstract：:Supersolids are exotic materials combining the frictionless flow of a superfluid with the crystal-like periodic density modulation of a solid. The supersolid phase of matter was predicted 50 years ago1-3 for solid helium4-8. Ultracold quantum gases have recently been made to exhibit periodic order typical of a crystal...

journal_title：Nature

authors： Tanzi L,Roccuzzo SM,Lucioni E,Famà F,Fioretti A,Gabbanini C,Modugno G,Recati A,Stringari S

更新日期：2019-10-01 00:00:00

abstract：:Understanding the behaviour of the dielectric constant in ferroelectric thin films remains a challenging problem. These ferroelectric materials have high static dielectric constants, and so are important for their applications in high-storage-density capacitor structures such as dynamic random access memory (DRAM). Bu...

journal_title：Nature

authors： Sirenko AA,Bernhard C,Golnik A,Clark AM,Hao J,Si W,Xi XX

更新日期：2000-03-23 00:00:00

abstract：:The US Congress is well-known for tucking special provisions for favoured projects into budget bills. David Goldston explains why 'earmarks' for research and development have risen so dramatically in recent years. ...

journal_title：Nature

authors： Goldston D

更新日期：2007-06-07 00:00:00

abstract：:The TGF-beta/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. The signal originated by TGF-beta-like molecules appears to be transduced by a set of evolutionarily conserved proteins known as SMADs, which upon activation di...

journal_title：Nature

authors： Lagna G,Hata A,Hemmati-Brivanlou A,Massagué J

更新日期：1996-10-31 00:00:00