Bacterial pathogenomics.

abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...

journal_title：Nature

authors： Foote M,Sepkoski JJ Jr

更新日期：1999-04-01 00:00:00

abstract：:Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control lifespan. Here we show that the hypothalamus is important for the development of whole-body ageing in mice, and that the un...

journal_title：Nature

authors： Zhang G,Li J,Purkayastha S,Tang Y,Zhang H,Yin Y,Li B,Liu G,Cai D

更新日期：2013-05-09 00:00:00

abstract：:Phylogenetic analysis of early tetrapod evolution has resulted in a consensus across diverse data sets in which the tetrapod stem group is a relatively homogenous collection of medium- to large-sized animals showing a progressive loss of 'fish' characters as they become increasingly terrestrial, whereas the crown grou...

journal_title：Nature

authors： Pardo JD,Szostakiwskyj M,Ahlberg PE,Anderson JS

更新日期：2017-06-29 00:00:00

abstract：:The mammalian microbiome has many important roles in health and disease, and genetic engineering is enabling the development of microbial therapeutics and diagnostics. A key determinant of the activity of both natural and engineered microorganisms in vivo is their location within the host organism. However, existing m...

journal_title：Nature

authors： Bourdeau RW,Lee-Gosselin A,Lakshmanan A,Farhadi A,Kumar SR,Nety SP,Shapiro MG

更新日期：2018-01-03 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory respons...

journal_title：Nature

authors： Carvelli J,Demaria O,Vély F,Batista L,Chouaki Benmansour N,Fares J,Carpentier S,Thibult ML,Morel A,Remark R,André P,Represa A,Piperoglou C,Explore COVID-19 IPH group.,Explore COVID-19 Marseille Immunopole group.,Cordier PY

更新日期：2020-12-01 00:00:00

abstract：:We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, reveali...

journal_title：Nature

authors： Keane TM,Goodstadt L,Danecek P,White MA,Wong K,Yalcin B,Heger A,Agam A,Slater G,Goodson M,Furlotte NA,Eskin E,Nellåker C,Whitley H,Cleak J,Janowitz D,Hernandez-Pliego P,Edwards A,Belgard TG,Oliver PL,McIntyre RE,

更新日期：2011-09-14 00:00:00

abstract：:It is possible to infer aspects of an organism's lifestyle from its gene content. Can the reverse also be done? Here we consider this issue by modelling evolution of the reduced genomes of endosymbiotic bacteria. The diversity of gene content in these bacteria may reflect both variation in selective forces and conting...

journal_title：Nature

authors： Pál C,Papp B,Lercher MJ,Csermely P,Oliver SG,Hurst LD

更新日期：2006-03-30 00:00:00

abstract：:To understand the processes that regulate the abundance and persistence of wild populations is a fundamental goal of ecology and a prerequisite for the management of living resources. Variable abundance data, however, make the demonstration of regulation processes challenging. A previously overlooked aspect in underst...

journal_title：Nature

authors： Minto C,Myers RA,Blanchard W

更新日期：2008-03-20 00:00:00

abstract：:The age of dense interstellar cloud cores, where stars and planets form, is a crucial parameter in star formation and difficult to measure. Some models predict rapid collapse, whereas others predict timescales of more than one million years (ref. 3). One possible approach to determining the age is through chemical cha...

journal_title：Nature

authors： Brünken S,Sipilä O,Chambers ET,Harju J,Caselli P,Asvany O,Honingh CE,Kamiński T,Menten KM,Stutzki J,Schlemmer S

更新日期：2014-12-11 00:00:00

abstract：:The angle between the spin of a star and the orbital planes of its planets traces the history of the planetary system. Exoplanets orbiting close to cool stars are expected to be on circular, aligned orbits because of strong tidal interactions with the stellar convective envelope. Spin-orbit alignment can be measured w...

journal_title：Nature

authors： Bourrier V,Lovis C,Beust H,Ehrenreich D,Henry GW,Astudillo-Defru N,Allart R,Bonfils X,Ségransan D,Delfosse X,Cegla HM,Wyttenbach A,Heng K,Lavie B,Pepe F

更新日期：2018-01-25 00:00:00

abstract：:Although freeze-fracture electron microscopy is normally analysed with the presumption that particles represent proteins embedded within the membrane, particles which appeared to represent inverted lipid micelles within membranes have been reported. I have now confirmed the occurrence of particles in protein-free lipo...

journal_title：Nature

authors： Miller RG

更新日期：1980-09-11 00:00:00

abstract：:The difficulty of working with the intact brain in vivo has led to the increasing use of nerve cell cultures in neurobiology. However, dissociated cells cannot be unambiguously identified by morphological criteria before the third week in culture, for it is not until then that the basic morphology and size of neurones...

journal_title：Nature

authors： Hooghe-Peters EL,Fowlkes BJ,Hooghe RJ

更新日期：1979-10-04 00:00:00

abstract：:Self-assembled polyhedral structures are common in biology. The coats of many viruses, for example, have a structure based on icosahedral symmetry. The preparation of synthetic polyhedral molecular assemblies represents a challenging problem, but supramolecular chemistry has now advanced to the point where the task ma...

journal_title：Nature

authors： Olenyuk B,Whiteford JA,Fechtenkötter A,Stang PJ

更新日期：1999-04-29 00:00:00

abstract：:Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologu...

journal_title：Nature

authors： Reed MB,Saliba KJ,Caruana SR,Kirk K,Cowman AF

更新日期：2000-02-24 00:00:00

abstract：:The existence in the ocean of deep western boundary currents, which connect the high-latitude regions where deep water is formed with upwelling regions as part of the global ocean circulation, was postulated more than 40 years ago. These ocean currents have been found adjacent to the continental slopes of all ocean ba...

journal_title：Nature

authors： Dengler M,Schott FA,Eden C,Brandt P,Fischer J,Zantopp RJ

更新日期：2004-12-23 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al. report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies deta...

journal_title：Nature

authors： Cram DS,Song B,Trounson AO

更新日期：2007-11-22 00:00:00

abstract：:The fundamental properties of neutron stars provide a direct test of the equation of state of cold nuclear matter, a relationship between pressure and density that is determined by the physics of the strong interactions between the particles that constitute the star. The most straightforward method of determining thes...

journal_title：Nature

authors： Cottam J,Paerels F,Mendez M

更新日期：2002-11-07 00:00:00

abstract：:THE cause of extinction of the woolly mammoth, Mammuthus primigenius (Blumenbach), is still debated. A major environmental change at the Pleistocene-Holocene boundary, hunting by early man, or both together are among the main explanations that have been suggested. But hardly anyone has doubted that mammoths had become...

journal_title：Nature

authors： Vartanyan SL,Garutt VE,Sher AV

更新日期：1993-03-25 00:00:00

abstract：:Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...

journal_title：Nature

authors： Nakai J,Dirksen RT,Nguyen HT,Pessah IN,Beam KG,Allen PD

更新日期：1996-03-07 00:00:00

abstract：:An analysis of 15 protein structures indicates: First, the loss of accessible surface area by monomeric proteins on folding-proportional to hydrophobic energy-is a simple function of molecular weight; second, the proportion of polar groups forming intramolecular hydrogen bonds is constant; and third, protein interiors...

journal_title：Nature

authors： Chothia C

更新日期：1975-03-27 00:00:00

abstract：:A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is co...

journal_title：Nature

authors： Amos LA,Baker TS

更新日期：1979-06-14 00:00:00

abstract：:Clouds on Titan result from the condensation of methane and ethane and, as on other planets, are primarily structured by circulation of the atmosphere. At present, cloud activity mainly occurs in the southern (summer) hemisphere, arising near the pole and at mid-latitudes from cumulus updrafts triggered by surface hea...

journal_title：Nature

authors： Rodriguez S,Le Mouélic S,Rannou P,Tobie G,Baines KH,Barnes JW,Griffith CA,Hirtzig M,Pitman KM,Sotin C,Brown RH,Buratti BJ,Clark RN,Nicholson PD

更新日期：2009-06-04 00:00:00

abstract：:Cells subjected to a heat shock, or a variety of other stresses increase the synthesis of a set of proteins, known as heat shock proteins. This response is apparently universal, occurring in the entire range from bacterial to mammalian cells. In Escherichia coli heat shock protein synthesis transiently increases follo...

journal_title：Nature

authors： Straus DB,Walter WA,Gross CA

更新日期：1987-09-24 00:00:00

abstract：:Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks. All type II topoisomerases described so far are members of a single protein family. We have cloned and sequenced the genes encoding the A and...

journal_title：Nature

authors： Bergerat A,de Massy B,Gadelle D,Varoutas PC,Nicolas A,Forterre P

更新日期：1997-03-27 00:00:00

abstract：:Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...

journal_title：Nature

authors： Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

更新日期：2018-01-11 00:00:00

abstract：:Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly und...

journal_title：Nature

authors： Afek A,Shi H,Rangadurai A,Sahay H,Senitzki A,Xhani S,Fang M,Salinas R,Mielko Z,Pufall MA,Poon GMK,Haran TE,Schumacher MA,Al-Hashimi HM,Gordân R

更新日期：2020-11-01 00:00:00

abstract：:Growth factors such as platelet-derived growth factor (PDGF) elicit the transcriptional activation of a large number of immediate early genes (many of which encode transcription factors), and ultimately DNA synthesis. Both AP1 and Myc are activated in fibroblasts in response to growth factor stimulation, and various e...

journal_title：Nature

authors： Barone MV,Courtneidge SA

更新日期：1995-11-30 00:00:00

abstract：:B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Dev...

journal_title：Nature

authors： Russell DM,Dembić Z,Morahan G,Miller JF,Bürki K,Nemazee D

更新日期：1991-11-28 00:00:00

abstract：:DNA repair by homologous recombination is highly suppressed in G1 cells to ensure that mitotic recombination occurs solely between sister chromatids. Although many homologous recombination factors are cell-cycle regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G...

journal_title：Nature

authors： Orthwein A,Noordermeer SM,Wilson MD,Landry S,Enchev RI,Sherker A,Munro M,Pinder J,Salsman J,Dellaire G,Xia B,Peter M,Durocher D

更新日期：2015-12-17 00:00:00