Abstract:
:Growth factors such as platelet-derived growth factor (PDGF) elicit the transcriptional activation of a large number of immediate early genes (many of which encode transcription factors), and ultimately DNA synthesis. Both AP1 and Myc are activated in fibroblasts in response to growth factor stimulation, and various experiments suggest their importance in proliferation. Src family kinases are required for PDGF (and other growth factors) to induce DNA synthesis. We have examined which transcription factors, when constitutively expressed, 'rescue' the block elicited by dominant negative Src. We report here that Myc, but not Fos and/or Jun, was able to rescue the block. In contrast, Fos and Jun, but not Myc, rescued the block induced by dominant negative Ras. Our data suggest that Src kinases control the transcriptional activation of Myc.
journal_name
Naturejournal_title
Natureauthors
Barone MV,Courtneidge SAdoi
10.1038/378509a0subject
Has Abstractpub_date
1995-11-30 00:00:00pages
509-12issue
6556eissn
0028-0836issn
1476-4687journal_volume
378pub_type
杂志文章相关文献
NATURE文献大全abstract::The Milankovitch theory states that global climate variability on orbital timescales from tens to hundreds of thousands of years is dominated by the summer insolation at high northern latitudes. The supporting evidence includes reconstructed air temperatures in Antarctica that are nearly in phase with boreal summer in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09825
更新日期:2011-03-03 00:00:00
abstract::The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07731
更新日期:2009-04-09 00:00:00
abstract::Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363179a0
更新日期:1993-05-13 00:00:00
abstract::Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation-unlike all other histone modifications-was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking o...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature04048
更新日期:2005-08-25 00:00:00
abstract::Phase and antigenic variation of pilin expression in Neisseria gonorrhoeae result from recombination events in which variant sequences from one of the silent loci (pilS) are transferred to the expression locus (pilE). Such rearrangements were originally thought to be gene conversions, but findings showing that phase v...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338651a0
更新日期:1989-04-20 00:00:00
abstract::The tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents. As p53 is a transcriptional activator that mediates gene induction after DNA damage, it has been proposed to be a genetic switch that activates apoptosis-mediator genes. Here we evaluate the role of p53 in DNA-dam...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370220a0
更新日期:1994-07-21 00:00:00
abstract::Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10074
更新日期:2011-05-12 00:00:00
abstract::Germinal centres are specialized structures wherein B lymphocytes undergo clonal expansion, class switch recombination, antibody gene diversification and affinity maturation. Three to four antigen-specific B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-centre centroblas...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05573
更新日期:2007-03-01 00:00:00
abstract::Hydrophobic signal-sequences direct the transfer of secretory proteins across the inner membrane of prokaryotes and the endoplasmic reticulum membranes of eukaryotes. In mammalian cells, signal-sequences are recognized by the 54K protein (M(r) 54,000) of the signal recognition particle (SRP) which is believed to hold ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359741a0
更新日期:1992-10-22 00:00:00
abstract::'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308237a0
更新日期:1984-03-15 00:00:00
abstract::The enzyme isopenicillin N synthetase (IPS) catalyses the oxidative condensation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (LLD-ACV) to isopenicillin N, which is a central reaction in the pathway to clinically important penicillins and cephalosporins. Here we report the cloning, characterization and expressi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318191a0
更新日期:1985-11-14 00:00:00
abstract::The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353521a0
更新日期:1991-10-10 00:00:00
abstract::This corrects the article DOI: 10.1038/nature21725. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/nature23659
更新日期:2017-08-31 00:00:00
abstract::Phosphorylation of membrane components is thought to be an important process in membrane function. Phosphorylated proteins and a special class of phospholipids, the (poly)phosphoinositides (poly PI), are implicated in the regulation of membrane permeability and synaptic transmission in neurones. For many years, protei...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286623a0
更新日期:1980-08-07 00:00:00
abstract::The development of colloidal quantum dots has led to practical applications of quantum confinement, such as in solution-processed solar cells, lasers and as biological labels. Further scientific and technological advances should be achievable if these colloidal quantum systems could be electronically coupled in a gene...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02695
更新日期:2004-07-08 00:00:00
abstract::Humans and other animals must often make decisions on the basis of imperfect evidence. Statisticians use measures such as P values to assign degrees of confidence to propositions, but little is known about how the brain computes confidence estimates about decisions. We explored this issue using behavioural analysis an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07200
更新日期:2008-09-11 00:00:00
abstract::Regulation of transcription initiation by proteins binding at DNA sequences some distance from the promoter region itself seems to be a general phenomenon in both eukaryotes and prokaryotes. Proteins bound to an enhancer site in eukaryotes can turn on a distant gene, whereas efficient repression of some prokaryotic ge...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325823a0
更新日期:1987-02-26 00:00:00
abstract::Macroscopic mechanical oscillators have been coaxed into a regime of quantum behaviour by direct refrigeration or a combination of refrigeration and laser-like cooling. This result supports the idea that mechanical oscillators may perform useful functions in the processing of quantum information with superconducting c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11915
更新日期:2013-03-14 00:00:00
abstract::Mitochondrial cytochrome oxidase is a functionally complex, membrane-bound respiratory enzyme which catalyses both the reduction of O2 to water and proton-pumping. During respiration, an exogenous donor, cytochrome c, donates four electrons to O2 bound at the bimetallic haem alpha 3 Fe-Cu centre within the enzyme. The...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338776a0
更新日期:1989-04-27 00:00:00
abstract::Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21039
更新日期:2017-02-09 00:00:00
abstract::Microbes comprise the majority of extant organisms, yet much remains to be learned about the nature and driving forces of microbial diversification. Our understanding of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns of genetic exchange, particularly if analyses target...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05624
更新日期:2007-03-29 00:00:00
abstract::Crystal structures of insulin have been determined in various distinct forms, the relevance of which to receptor recognition has long been the subject of speculation. Recently the crystal structure of an inactive insulin analogue has been determined and, surprisingly, found to have a conformation identical to native i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/354238a0
更新日期:1991-11-21 00:00:00
abstract::Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13608
更新日期:2014-09-04 00:00:00
abstract::Four incorrect figure citations in this Letter have been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0560-x
更新日期:2018-11-01 00:00:00
abstract::The satellites Rhea and Dione orbit within the magnetosphere of Saturn, where they are exposed to particle irradiation from trapped ions. A similar situation applies to the galilean moons Europa, Ganymede and Callisto, which reside within Jupiter's radiation belts. All of these satellites have surfaces rich in water i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40348
更新日期:1997-07-03 00:00:00
abstract::The discovery that atrial extracts have potent diuretic and natriuretic properties revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial na...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326697a0
更新日期:1987-04-16 00:00:00
abstract::Mature cortical pyramidal neurons receive excitatory inputs onto small protrusions emanating from their dendrites called spines. Spines undergo activity-dependent remodelling, stabilization and pruning during development, and similar structural changes can be triggered by learning and changes in sensory experiences. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09986
更新日期:2011-06-02 00:00:00
abstract::The antigen CD10 (common acute lymphoblastic leukaemia antigen), which is the zinc metalloprotease, neutral endopeptidase 24.11 (also known as NEP or 'enkephalinase'), is expressed by acute lymphoblastic leukaemias, normal lymphoid progenitors, mature polymorphonuclear leukocytes and certain nonhaematopoietic cells. C...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347394a0
更新日期:1990-09-27 00:00:00
abstract::Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/440163a
更新日期:2006-03-09 00:00:00
abstract::Leukaemia inhibitory factor (LIF) has a variety of effects on different cell types in vitro, inhibiting the differentiation of embryonic stem cells and promoting the survival and/or proliferation of primitive haematopoietic precursors and primordial germ cells. Here we show that LIF-deficient mice derived by gene targ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363361a0
更新日期:1993-05-27 00:00:00