Hidden morphological diversity among early tetrapods.

abstract：:Infertility resulting from a severe defect in sperm production affects 2% of men worldwide. Of these men with azoospermia, the absence of sperm in semen, one in eight carry de novo deletions for a specific region of the Y chromosome. A candidate gene for the Y-chromosome azoospermia factor (AZF) has been identified an...

journal_title：Nature

authors： Eberhart CG,Maines JZ,Wasserman SA

更新日期：1996-06-27 00:00:00

abstract：:Novel capsomeric complexes, pentamers and hexamers were detected as chemical entities in phage Q beta. Both were composed of identical protein subunits and stabilized by intermolecular disulphide bonds. Their numbers per particle were about 12 for pentamers and about 20 for hexamers--consistent with theoretical expect...

journal_title：Nature

authors： Takamatsu H,Iso K

更新日期：1982-08-26 00:00:00

abstract：:Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T cells. However, it is not known which proteases are required for antigen processing. To investigate this, we e...

journal_title：Nature

authors： Manoury B,Hewitt EW,Morrice N,Dando PM,Barrett AJ,Watts C

更新日期：1998-12-17 00:00:00

abstract：:Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly reg...

journal_title：Nature

authors： van Leyen K,Duvoisin RM,Engelhardt H,Wiedmann M

更新日期：1998-09-24 00:00:00

abstract：:Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana...

journal_title：Nature

authors： Schacherer J,Shapiro JA,Ruderfer DM,Kruglyak L

更新日期：2009-03-19 00:00:00

abstract：:Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various cancers. Commo...

journal_title：Nature

authors： Letessier A,Millot GA,Koundrioukoff S,Lachagès AM,Vogt N,Hansen RS,Malfoy B,Brison O,Debatisse M

更新日期：2011-02-03 00:00:00

abstract：: ...

journal_title：Nature

authors： Rios Rojas C

更新日期：2018-12-01 00:00:00

abstract：:In the chick embryo hindbrain, morphological segmentation into rhombomeres is matched by metameric patterns of early neuronal differentiation and axonogenesis. Boundaries between rhombomeres coincide with boundaries of expression of murine regulatory genes. By clonal analysis using intracellular marking, we show here ...

journal_title：Nature

authors： Fraser S,Keynes R,Lumsden A

更新日期：1990-03-29 00:00:00

abstract：:Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding...

journal_title：Nature

authors： Liu B,Xu Q,Wang Q,Feng S,Lai F,Wang P,Zheng F,Xiang Y,Wu J,Nie J,Qiu C,Xia W,Li L,Yu G,Lin Z,Xu K,Xiong Z,Kong F,Liu L,Huang C,Yu Y,Na J,Xie W

更新日期：2020-11-01 00:00:00

abstract：:Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands. However, coupled replication presents a largely unrecognized topological problem. Because DNA polymerase must travel a helical path during synthesis, the physical connection between leading- ...

journal_title：Nature

authors： Kurth I,Georgescu RE,O'Donnell ME

更新日期：2013-04-04 00:00:00

abstract：:The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes ...

journal_title：Nature

authors： De Rubeis S,He X,Goldberg AP,Poultney CS,Samocha K,Cicek AE,Kou Y,Liu L,Fromer M,Walker S,Singh T,Klei L,Kosmicki J,Shih-Chen F,Aleksic B,Biscaldi M,Bolton PF,Brownfeld JM,Cai J,Campbell NG,Carracedo A,Chahrour

更新日期：2014-11-13 00:00:00

abstract：:China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...

journal_title：Nature

authors： Piao S,Ciais P,Huang Y,Shen Z,Peng S,Li J,Zhou L,Liu H,Ma Y,Ding Y,Friedlingstein P,Liu C,Tan K,Yu Y,Zhang T,Fang J

更新日期：2010-09-02 00:00:00

abstract：:The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease. Accordingly, neurons invest considerable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain proteostasis an...

journal_title：Nature

authors： Melentijevic I,Toth ML,Arnold ML,Guasp RJ,Harinath G,Nguyen KC,Taub D,Parker JA,Neri C,Gabel CV,Hall DH,Driscoll M

更新日期：2017-02-16 00:00:00

abstract：:The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...

journal_title：Nature

authors： Ptashne M,Gann A

更新日期：1997-04-10 00:00:00

abstract：:Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop nat...

journal_title：Nature

authors： Sullivan NJ,Sanchez A,Rollin PE,Yang ZY,Nabel GJ

更新日期：2000-11-30 00:00:00

abstract：:Compartments in food webs are subgroups of taxa in which many strong interactions occur within the subgroups and few weak interactions occur between the subgroups. Theoretically, compartments increase the stability in networks, such as food webs. Compartments have been difficult to detect in empirical food webs becaus...

journal_title：Nature

authors： Krause AE,Frank KA,Mason DM,Ulanowicz RE,Taylor WW

更新日期：2003-11-20 00:00:00

abstract：:It is well established that the osteoclast is formed by fusion of post-mitotic, mononuclear precursors derived from circulating progenitor cells. However, the precise haematopoietic origin of the osteoclast is unknown. We have investigated this here by fractionating mouse bone marrow and isolating haematopoietic stem ...

journal_title：Nature

authors： Scheven BA,Visser JW,Nijweide PJ

更新日期：1986-05-01 00:00:00

abstract：:Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...

journal_title：Nature

authors： van 't Veer LJ,Dai H,van de Vijver MJ,He YD,Hart AA,Mao M,Peterse HL,van der Kooy K,Marton MJ,Witteveen AT,Schreiber GJ,Kerkhoven RM,Roberts C,Linsley PS,Bernards R,Friend SH

更新日期：2002-01-31 00:00:00

abstract：:Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...

journal_title：Nature

authors： Yang XD,Korn H,Faber DS

更新日期：1990-12-06 00:00:00

abstract：:A quantum internet that connects remote quantum processors1,2 should enable a number of revolutionary applications such as distributed quantum computing. Its realization will rely on entanglement of remote quantum memories over long distances. Despite enormous progress3-12, at present the maximal physical separation a...

journal_title：Nature

authors： Yu Y,Ma F,Luo XY,Jing B,Sun PF,Fang RZ,Yang CW,Liu H,Zheng MY,Xie XP,Zhang WJ,You LX,Wang Z,Chen TY,Zhang Q,Bao XH,Pan JW

更新日期：2020-02-01 00:00:00

abstract：:The neuronal structure and connectivity underlying receptive field organisation of cells in the cat visual cortex have been investigated. Intracellular recordings were made using a micropipette filled with a histochemical marker, which was injected into the cells after their receptive fields had been characterised. Th...

journal_title：Nature

authors： Gilbert CD,Wiesel TN

更新日期：1979-07-12 00:00:00

abstract：:A balance between pro- and anti-inflammatory mechanisms at mucosal interfaces, which are sites of constitutive exposure to microbes and non-microbial foreign substances, allows for efficient protection against pathogens yet prevents adverse inflammatory responses associated with allergy, asthma and intestinal inflamma...

journal_title：Nature

authors： Josefowicz SZ,Niec RE,Kim HY,Treuting P,Chinen T,Zheng Y,Umetsu DT,Rudensky AY

更新日期：2012-02-08 00:00:00

abstract：:Bivalve molluscs, the primary vectors of paralytic shellfish poisoning (PSP) in humans, show marked inter-species variation in their capacity to accumulate PSP toxins (PSTs) which has a neural basis. PSTs cause human fatalities by blocking sodium conductance in nerve fibres. Here we identify a molecular basis for inte...

journal_title：Nature

authors： Bricelj VM,Connell L,Konoki K,Macquarrie SP,Scheuer T,Catterall WA,Trainer VL

更新日期：2005-04-07 00:00:00

abstract：:Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...

journal_title：Nature

authors： Nakatsu T,Ichiyama S,Hiratake J,Saldanha A,Kobashi N,Sakata K,Kato H

更新日期：2006-03-16 00:00:00

abstract：:The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...

journal_title：Nature

authors： Zachow KR,Ostrow RS,Bender M,Watts S,Okagaki T,Pass F,Faras AJ

更新日期：1982-12-23 00:00:00

abstract：:The ATP-dependent chromatin assembly and remodelling factor (ACF) functions to generate regularly spaced nucleosomes, which are required for heritable gene silencing. The mechanism by which ACF mobilizes nucleosomes remains poorly understood. Here we report a single-molecule FRET study that monitors the remodelling of...

journal_title：Nature

authors： Blosser TR,Yang JG,Stone MD,Narlikar GJ,Zhuang X

更新日期：2009-12-24 00:00:00

abstract：:Insulin stimulates glucose uptake in muscle and adipocytes by signalling the translocation of GLUT4 glucose transporters from intracellular membranes to the cell surface. The translocation of GLUT4 may involve signalling pathways that are both independent of and dependent on phosphatidylinositol-3-OH kinase (PI(3)K). ...

journal_title：Nature

authors： Bose A,Guilherme A,Robida SI,Nicoloro SM,Zhou QL,Jiang ZY,Pomerleau DP,Czech MP

更新日期：2002-12-19 00:00:00

abstract：:It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...

journal_title：Nature

authors： Cook DL,Hales CN

更新日期：1984-09-20 00:00:00

abstract：:What is it that defines an animal? The definition provided here, made on the basis of developmental biology, suggests methods for resolving phylogenetic problems. ...

journal_title：Nature

authors： Slack JM,Holland PW,Graham CF

更新日期：1993-02-11 00:00:00

abstract：:The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a s...

journal_title：Nature

authors： Calos MP

更新日期：1978-08-24 00:00:00