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Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae.

Abstract：

:Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana. Here we report a nucleotide-level survey of genomic variation in a diverse collection of 63 Saccharomyces cerevisiae strains sampled from different ecological niches (beer, bread, vineyards, immunocompromised individuals, various fermentations and nature) and from locations on different continents. We hybridized genomic DNA from each strain to whole-genome tiling microarrays and detected 1.89 million single nucleotide polymorphisms, which were grouped into 101,343 distinct segregating sites. We also identified 3,985 deletion events of length >200 base pairs among the surveyed strains. We analysed the genome-wide patterns of nucleotide polymorphism and deletion variants, and measured the extent of linkage disequilibrium in S. cerevisiae. These results and the polymorphism resource we have generated lay the foundation for genome-wide association studies in yeast. We also examined the population structure of S. cerevisiae, providing support for multiple domestication events as well as insight into the origins of pathogenic strains.

journal_name

Nature

journal_title

Nature

authors

Schacherer J,Shapiro JA,Ruderfer DM,Kruglyak L

doi

10.1038/nature07670

subject

Has Abstract

pub_date

2009-03-19 00:00:00

pages

342-5

issue

7236

eissn

0028-0836

issn

1476-4687

pii

nature07670

journal_volume

458

pub_type

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