Abstract:
:Cation-selective P2X receptor channels were first described in sensory neurons where they are important for primary afferent neurotransmission and nociception. Here we report the cloning of a complementary DNA (P2X3) from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. We also found RNA for (P2X1)(ref. 7), (P2X2)(ref. 8) and P2X4 (ref. 9) in sensory neurons; channels expressed from individual cDNAs did not reproduce those of sensory ganglia. Coexpression of P2X3 with P2X2, but not other combinations, yielded ATP-activated currents that closely resembled those in sensory neurons. These properties could not be accounted for by addition of the two sets of channels, indicating that a new channel had formed by subunit heteropolymerization. Although in some tissues responses to ATP can be accounted for by homomeric channels, our results indicate that ATP-gated channels of sensory neurons may form by a specific heteropolymerization of P2X receptor subunits.
journal_name
Naturejournal_title
Natureauthors
Lewis C,Neidhart S,Holy C,North RA,Buell G,Surprenant Adoi
10.1038/377432a0subject
Has Abstractpub_date
1995-10-05 00:00:00pages
432-5issue
6548eissn
0028-0836issn
1476-4687journal_volume
377pub_type
杂志文章相关文献
NATURE文献大全abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07046-0
更新日期:2018-10-01 00:00:00
abstract::Particle physicists see neutrons as tiny massive particles with a confinement radius of about 0.7 fm and a distinct internal quark gluon structure. In quantum mechanics, neutrons are described by wave packets whose spatial extent may become ten orders of magnitude larger than the confinement radius, and can even reach...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00773
更新日期:2002-06-06 00:00:00
abstract::All of the DNA synthesis genes of budding yeast examined so far are periodically expressed and hence under cell-cycle control (Table 1). Expression occurs near the G1/S phase boundary and the genes seem to be coordinately regulated (reviewed in ref. 4). The upstream promoter sequences of these genes have only a hexame...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350247a0
更新日期:1991-03-21 00:00:00
abstract::Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in princi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10334
更新日期:2011-08-03 00:00:00
abstract::Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318377a0
更新日期:1985-11-28 00:00:00
abstract::'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308237a0
更新日期:1984-03-15 00:00:00
abstract::Polar molecules have a rich internal structure and long-range dipole-dipole interactions, making them useful for quantum-controlled applications and fundamental investigations. Their potential fully unfolds at ultracold temperatures, where various effects are predicted in many-body physics, quantum information science...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11595
更新日期:2012-11-22 00:00:00
abstract::Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature02624
更新日期:2004-05-27 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00393-6
更新日期:2019-02-01 00:00:00
abstract::The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature07425
更新日期:2008-11-06 00:00:00
abstract::Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anth...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01582
更新日期:2003-05-01 00:00:00
abstract::At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constitu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03029
更新日期:2004-12-23 00:00:00
abstract::In Dictyostelium discoideum, carbohydrate binding proteins (CBPs) or lectins have been implicated in the molecular basis of cellular cohesion. To determine the role of these CBPs, we have attempted to isolate structural gene mutants in which the CBPs have a defective affinity for carbohydrate ligands. We now report th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279215a0
更新日期:1979-05-17 00:00:00
abstract::A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/275496a0
更新日期:1978-10-12 00:00:00
abstract::Large-conductance Ca(2+)-gated K(+) (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. This group of channels can be activated synergistically by both voltage and intracellular Ca(2+), with the large carboxy-terminal intracellular portion being res...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09252
更新日期:2010-07-15 00:00:00
abstract::The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323728a0
更新日期:1986-10-23 00:00:00
abstract::The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase, as well as its ability to form unusual structures in...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/350569a0
更新日期:1991-04-18 00:00:00
abstract::First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/261459a0
更新日期:1976-06-10 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1062-1
更新日期:2019-04-01 00:00:00
abstract::Protecting the world's freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09440
更新日期:2010-09-30 00:00:00
abstract::Establishing the age at death of individuals is an important step in their identification and can be done with high precision up to adolescence by analysis of dentition, but it is more difficult in adults. Here we show that the amount of radiocarbon present in tooth enamel as a result of nuclear bomb testing during 19...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/437333a
更新日期:2005-09-15 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07589-2
更新日期:2018-12-01 00:00:00
abstract::The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmitted infections and major nosocomial infections. This syringe-shaped 3.5-MDa macromolecular ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20576
更新日期:2016-12-22 00:00:00
abstract::Little is known about the biochemical or functional nature of the proteins encoded by the bcl-2 gene, which undergoes chromosomal translocation in approximately 85% of follicular lymphoma, 20% of diffuse large cell lymphoma and 10% of chronic lymphocytic leukaemia of B cells. Translocation of bcl-2 sequences from chro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342195a0
更新日期:1989-11-09 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 信件
doi:10.1038/d41586-018-07308-x
更新日期:2018-11-01 00:00:00
abstract::Joining dissimilar materials such as plastics and metals in engineered structures remains a challenge1. Mechanical fastening, conventional welding and adhesive bonding are examples of techniques currently used for this purpose, but each of these methods presents its own set of problems2 such as formation of stress con...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2813-8
更新日期:2020-10-01 00:00:00
abstract::Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example, the association of membrane proteins with proteins on different cells (trans-interactions) can drive the oligomerization of proteins on t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10183
更新日期:2011-07-27 00:00:00
abstract::During cell division, sister chromosomes segregate from each other on a microtubule-based structure called the mitotic spindle. Proteins bind to the centromere, a region of chromosomal DNA, to form the kinetochore, which mediates chromosome attachment to the mitotic spindle microtubules. In the budding yeast Saccharom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359533a0
更新日期:1992-10-08 00:00:00
abstract::The retinotectal projection has long been studied experimentally and theoretically, as a model for the formation of topographic brain maps. Neighbouring retinal ganglion cells (RGCs) project their axons to neighbouring positions in the optic tectum, thus re-establishing a continuous neural representation of visual spa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06816
更新日期:2008-04-17 00:00:00
abstract::Zooxanthellae, endosymbiotic algae of reef-building corals, substantially contribute to the high gross primary production of coral reefs, but corals exude up to half of the carbon assimilated by their zooxanthellae as mucus. Here we show that released coral mucus efficiently traps organic matter from the water column ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02344
更新日期:2004-03-04 00:00:00