Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.

abstract：:Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs ...

journal_title：Nature

authors： Myung K,Chen C,Kolodner RD

更新日期：2001-06-28 00:00:00

abstract：:To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...

journal_title：Nature

authors： Beck JR,Muralidharan V,Oksman A,Goldberg DE

更新日期：2014-07-31 00:00:00

abstract：:The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We i...

journal_title：Nature

authors： Elliott LT,Sharp K,Alfaro-Almagro F,Shi S,Miller KL,Douaud G,Marchini J,Smith SM

更新日期：2018-10-01 00:00:00

abstract：:Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the maturation or repair of the functional 3' end of tRNAs by means of the addition of the essential nucleotides CCA. However, it is unclear how tRNA nucleotidyltransferases polymerize CCA onto the 3' terminus of immature tRNAs without using...

journal_title：Nature

authors： Xiong Y,Steitz TA

更新日期：2004-08-05 00:00:00

abstract：:Originally described by Lugaresi et al. in 1986 (ref. 1), fatal familial insomnia (FFI) is a rare inherited neurological disease characterized by the subacute progression of intractable insomnia and other autonomic abnormalities, cerebellar and pyramidal signs, myoclonus and dementia; neuropathologically, the major fe...

journal_title：Nature

authors： Tateishi J,Brown P,Kitamoto T,Hoque ZM,Roos R,Wollman R,Cervenáková L,Gajdusek DC

更新日期：1995-08-03 00:00:00

abstract：:Living organisms rely on simultaneous reactions catalysed by mutually compatible and selective enzymes to synthesize complex natural products and other metabolites. To combine the advantages of these biological systems with the reactivity of artificial chemical catalysts, chemists have devised sequential, concurrent, ...

journal_title：Nature

authors： Litman ZC,Wang Y,Zhao H,Hartwig JF

更新日期：2018-08-01 00:00:00

abstract：:Pyroptosis is a form of cell death that is critical for immunity. It can be induced by the canonical caspase-1 inflammasomes or by activation of caspase-4, -5 and -11 by cytosolic lipopolysaccharide. The caspases cleave gasdermin D (GSDMD) in its middle linker to release autoinhibition on its gasdermin-N domain, which...

journal_title：Nature

authors： Wang Y,Gao W,Shi X,Ding J,Liu W,He H,Wang K,Shao F

更新日期：2017-07-06 00:00:00

abstract：:The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...

journal_title：Nature

authors： Settleman J,Albright CF,Foster LC,Weinberg RA

更新日期：1992-09-10 00:00:00

abstract：:Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...

journal_title：Nature

authors： Kong X,Kuilman T,Shahrabi A,Boshuizen J,Kemper K,Song JY,Niessen HWM,Rozeman EA,Geukes Foppen MH,Blank CU,Peeper DS

更新日期：2017-10-12 00:00:00

abstract：:The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...

journal_title：Nature

authors： Wang KC,Koprivica V,Kim JA,Sivasankaran R,Guo Y,Neve RL,He Z

更新日期：2002-06-27 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-02-01 00:00:00

abstract：:Introduced in its contemporary form in 1946 (ref. 1), but with roots that go back to the eighteenth century, the gravity law is the prevailing framework with which to predict population movement, cargo shipping volume and inter-city phone calls, as well as bilateral trade flows between nations. Despite its widespread ...

journal_title：Nature

authors： Simini F,González MC,Maritan A,Barabási AL

更新日期：2012-02-26 00:00:00

abstract：:Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies. Many MLL-fusion partners are members of the super elongation complex (SEC), a critical regulator of transcriptional elongation, suggesting ...

journal_title：Nature

authors： Dawson MA,Prinjha RK,Dittmann A,Giotopoulos G,Bantscheff M,Chan WI,Robson SC,Chung CW,Hopf C,Savitski MM,Huthmacher C,Gudgin E,Lugo D,Beinke S,Chapman TD,Roberts EJ,Soden PE,Auger KR,Mirguet O,Doehner K,Delwel R,

更新日期：2011-10-02 00:00:00

abstract：: ...

journal_title：Nature

authors： Schiermeier Q

更新日期：2019-02-01 00:00:00

abstract：:More than twenty types of retinal ganglion cells conduct visual information from the eye to the rest of the brain. Each retinal ganglion cell type tessellates the retina in a regular mosaic, so that every point in visual space is processed for visual primitives such as contrast and motion. This information flows to tw...

journal_title：Nature

authors： Feinberg EH,Meister M

更新日期：2015-03-12 00:00:00

abstract：:Mechanotransduction has an important role in physiology. Biological processes including sensing touch and sound waves require as-yet-unidentified cation channels that detect pressure. Mouse Piezo1 (MmPiezo1) and MmPiezo2 (also called Fam38a and Fam38b, respectively) induce mechanically activated cationic currents in c...

journal_title：Nature

authors： Coste B,Xiao B,Santos JS,Syeda R,Grandl J,Spencer KS,Kim SE,Schmidt M,Mathur J,Dubin AE,Montal M,Patapoutian A

更新日期：2012-02-19 00:00:00

abstract：:We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness...

journal_title：Nature

authors： Le Chatelier E,Nielsen T,Qin J,Prifti E,Hildebrand F,Falony G,Almeida M,Arumugam M,Batto JM,Kennedy S,Leonard P,Li J,Burgdorf K,Grarup N,Jørgensen T,Brandslund I,Nielsen HB,Juncker AS,Bertalan M,Levenez F,Pons N,

更新日期：2013-08-29 00:00:00

abstract：:The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...

journal_title：Nature

authors： Pin JP,Bettler B

更新日期：2016-12-01 00:00:00

abstract：:Cation-selective P2X receptor channels were first described in sensory neurons where they are important for primary afferent neurotransmission and nociception. Here we report the cloning of a complementary DNA (P2X3) from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. We also found...

journal_title：Nature

authors： Lewis C,Neidhart S,Holy C,North RA,Buell G,Surprenant A

更新日期：1995-10-05 00:00:00

abstract：:T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment1. The function of T cells is tightly regulated by a combinational co-stimulatory signal, and dominance of negative co-stimulation results in T cell dysfunction2. However, the molecular m...

journal_title：Nature

authors： Liu X,Wang Y,Lu H,Li J,Yan X,Xiao M,Hao J,Alekseev A,Khong H,Chen T,Huang R,Wu J,Zhao Q,Wu Q,Xu S,Wang X,Jin W,Yu S,Wang Y,Wei L,Wang A,Zhong B,Ni L,Liu X,Nurieva R,Ye L,Tian Q,Bian XW,Dong C

更新日期：2019-03-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Pappalardo JL,Hafler DA

更新日期：2019-02-01 00:00:00

abstract：:Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM cells generated by viral infection of the skin differentially ex...

journal_title：Nature

authors： Pan Y,Tian T,Park CO,Lofftus SY,Mei S,Liu X,Luo C,O'Malley JT,Gehad A,Teague JE,Divito SJ,Fuhlbrigge R,Puigserver P,Krueger JG,Hotamisligil GS,Clark RA,Kupper TS

更新日期：2017-03-09 00:00:00

abstract：:Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...

journal_title：Nature

authors： Jonsson P,Bandlamudi C,Cheng ML,Srinivasan P,Chavan SS,Friedman ND,Rosen EY,Richards AL,Bouvier N,Selcuklu SD,Bielski CM,Abida W,Mandelker D,Birsoy O,Zhang L,Zehir A,Donoghue MTA,Baselga J,Offit K,Scher HI,O'Reill

更新日期：2019-07-01 00:00:00

abstract：:Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various cancers. Commo...

journal_title：Nature

authors： Letessier A,Millot GA,Koundrioukoff S,Lachagès AM,Vogt N,Hansen RS,Malfoy B,Brison O,Debatisse M

更新日期：2011-02-03 00:00:00

abstract：:Expression of Ets2, a proto-oncogene and transcription factor, occurs in a variety of cell types. During murine development it is highly expressed in newly forming cartilage, including in the skull precursor cells and vertebral primordia. Ets2 is located on human chromosome 21 (ref. 8) and is overexpressed in Down's s...

journal_title：Nature

authors： Sumarsono SH,Wilson TJ,Tymms MJ,Venter DJ,Corrick CM,Kola R,Lahoud MH,Papas TS,Seth A,Kola I

更新日期：1996-02-08 00:00:00

abstract：:Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...

journal_title：Nature

authors： Hynes TR,Kautz RA,Goodman MA,Gill JF,Fox RO

更新日期：1989-05-04 00:00:00

abstract：:Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating, better understanding of the mechanisms underlying obesity-associated cancer...

journal_title：Nature

authors： Yoshimoto S,Loo TM,Atarashi K,Kanda H,Sato S,Oyadomari S,Iwakura Y,Oshima K,Morita H,Hattori M,Honda K,Ishikawa Y,Hara E,Ohtani N

更新日期：2013-07-04 00:00:00

abstract：:Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an ep...

journal_title：Nature

authors： De Joussineau C,Soulé J,Martin M,Anguille C,Montcourrier P,Alexandre D

更新日期：2003-12-04 00:00:00

abstract：:A 7-A resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, alpha-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the s...

journal_title：Nature

authors： Henderson R,Unwin PN

更新日期：1975-09-04 00:00:00

abstract：:The mitotic recombination behaviour of a duplication of the his4 region on chromosome III in the yeast Saccharomyces cerevisiae was studied. The major recombination event between the duplicated segments is gene conversion unassociated with reciprocal recombination. The rad52-1 mutation preferentially decreases mitotic...

journal_title：Nature

authors： Jackson JA,Fink GR

更新日期：1981-07-23 00:00:00