Antarctic voyage will explore ocean hidden under ice for 100,000 years.

abstract：:IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than p...

journal_title：Nature

authors： Sutton BJ,Gould HJ

更新日期：1993-12-02 00:00:00

abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...

journal_title：Nature

authors： Mochizuki K,Matsumoto M,Ohmine I

更新日期：2013-06-20 00:00:00

abstract：:'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...

journal_title：Nature

authors： Sutcliffe JG,Milner RJ,Gottesfeld JM,Lerner RA

更新日期：1984-03-15 00:00:00

abstract：:Peroxisomes are among the intracellular organelles of eukaryotic cells that contain specialized sets of enzymes with specific functions. Little is known of membranous components involved in assembly of the intracellular compartments. We isolated two peroxisome-deficient and mutually complementary, Chinese hamster ovar...

journal_title：Nature

authors： Tsukamoto T,Miura S,Fujiki Y

更新日期：1991-03-07 00:00:00

abstract：:Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...

journal_title：Nature

authors： Winklbauer R,Medina A,Swain RK,Steinbeisser H

更新日期：2001-10-25 00:00:00

abstract：:Type 2 diabetes (T2D) is a result of complex gene-environment interactions, and several risk factors have been identified, including age, family history, diet, sedentary lifestyle and obesity. Statistical models that combine known risk factors for T2D can partly identify individuals at high risk of developing the dise...

journal_title：Nature

authors： Karlsson FH,Tremaroli V,Nookaew I,Bergström G,Behre CJ,Fagerberg B,Nielsen J,Bäckhed F

更新日期：2013-06-06 00:00:00

abstract：:The nuclear bulge is a region with a radius of about 200 parsecs around the centre of the Milky Way. It contains stars with ages ranging from a few million years to over a billion years, yet its star-formation history and the triggering process for star formation remain to be resolved. Recently, episodic star formatio...

journal_title：Nature

authors： Matsunaga N,Kawadu T,Nishiyama S,Nagayama T,Kobayashi N,Tamura M,Bono G,Feast MW,Nagata T

更新日期：2011-08-24 00:00:00

abstract：:The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...

journal_title：Nature

authors： Baleja JD,Marmorstein R,Harrison SC,Wagner G

更新日期：1992-04-02 00:00:00

abstract：:A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...

journal_title：Nature

authors： Human Microbiome Project Consortium.

更新日期：2012-06-13 00:00:00

abstract：:Change history: In this Letter, the received date should be 20 December 2017, instead of 27 April 2018. This has been corrected online. ...

journal_title：Nature

authors： Humphreys PC,Kalb N,Morits JPJ,Schouten RN,Vermeulen RFL,Twitchen DJ,Markham M,Hanson R

更新日期：2018-10-01 00:00:00

abstract：:Following the introduction of silicon-based integrated circuitry over three decades ago, the integration density of such circuits has doubled every 12 to 18 months: this observation is known as Moore's law. For this historical trend to continue, significant challenges need to be overcome in several key technological a...

journal_title：Nature

authors： Peercy PS

更新日期：2000-08-31 00:00:00

abstract：:Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...

journal_title：Nature

authors： Michaloglou C,Vredeveld LC,Soengas MS,Denoyelle C,Kuilman T,van der Horst CM,Majoor DM,Shay JW,Mooi WJ,Peeper DS

更新日期：2005-08-04 00:00:00

abstract：:The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...

journal_title：Nature

authors： Wang KC,Koprivica V,Kim JA,Sivasankaran R,Guo Y,Neve RL,He Z

更新日期：2002-06-27 00:00:00

abstract：:Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 t...

journal_title：Nature

authors： Santamaría D,Barrière C,Cerqueira A,Hunt S,Tardy C,Newton K,Cáceres JF,Dubus P,Malumbres M,Barbacid M

更新日期：2007-08-16 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...

journal_title：Nature

authors： Piscitelli CL,Krishnamurthy H,Gouaux E

更新日期：2010-12-23 00:00:00

abstract：:Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine re...

journal_title：Nature

authors： Garris PA,Kilpatrick M,Bunin MA,Michael D,Walker QD,Wightman RM

更新日期：1999-03-04 00:00:00

abstract：:Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metaz...

journal_title：Nature

authors： Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.

更新日期：2009-07-16 00:00:00

abstract：:The clinical benefit for patients with diverse types of metastatic cancers that has been observed upon blockade of the interaction between PD-1 and PD-L1 has highlighted the importance of this inhibitory axis in the suppression of tumour-specific T-cell responses. Notwithstanding the key role of PD-L1 expression by ce...

journal_title：Nature

authors： Mezzadra R,Sun C,Jae LT,Gomez-Eerland R,de Vries E,Wu W,Logtenberg MEW,Slagter M,Rozeman EA,Hofland I,Broeks A,Horlings HM,Wessels LFA,Blank CU,Xiao Y,Heck AJR,Borst J,Brummelkamp TR,Schumacher TNM

更新日期：2017-09-07 00:00:00

abstract：:At early stages of the mammalian visual cortex, neurons with similar stimulus selectivities are vertically arrayed through the thickness of the cortical sheet and clustered in patches or bands across the surface. This organization, referred to as a 'column', has been found with respect to one-dimensional stimulus para...

journal_title：Nature

authors： Fujita I,Tanaka K,Ito M,Cheng K

更新日期：1992-11-26 00:00:00

abstract：:The peptide GsMTx4, isolated from the venom of the tarantula Grammostola spatulata, is a selective inhibitor of stretch-activated cation channels (SACs). The mechanism of inhibition remains unknown; but both GsMTx4 and its enantiomer, enGsMTx4, modify the gating of SACs, thus violating a trademark of the traditional l...

journal_title：Nature

authors： Suchyna TM,Tape SE,Koeppe RE 2nd,Andersen OS,Sachs F,Gottlieb PA

更新日期：2004-07-08 00:00:00

abstract：:Complex topological configurations are fertile ground for exploring emergent phenomena and exotic phases in condensed-matter physics. For example, the recent discovery of polarization vortices and their associated complex-phase coexistence and response under applied electric fields in superlattices of (PbTiO3)n/(SrTiO...

journal_title：Nature

authors： Das S,Tang YL,Hong Z,Gonçalves MAP,McCarter MR,Klewe C,Nguyen KX,Gómez-Ortiz F,Shafer P,Arenholz E,Stoica VA,Hsu SL,Wang B,Ophus C,Liu JF,Nelson CT,Saremi S,Prasad B,Mei AB,Schlom DG,Íñiguez J,García-Fernández P

更新日期：2019-04-01 00:00:00

abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

journal_title：Nature

authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

更新日期：2016-02-11 00:00:00

abstract：:In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...

journal_title：Nature

authors： Belote JM,Lucchesi JC

更新日期：1980-06-19 00:00:00

abstract：:Molecular-scale manipulation of electronic and ionic charge accumulation in materials is the backbone of electrochemical energy storage1-4. Layered van der Waals (vdW) crystals are a diverse family of materials into which mobile ions can electrochemically intercalate into the interlamellar gaps of the host atomic latt...

journal_title：Nature

authors： Bediako DK,Rezaee M,Yoo H,Larson DT,Zhao SYF,Taniguchi T,Watanabe K,Brower-Thomas TL,Kaxiras E,Kim P

更新日期：2018-06-01 00:00:00

abstract：:Calcium permeability of basophil and mast cell membranes is stimulated on allergen binding to its specific membrane-bound IgE. This entry of Ca2+ ions into the cell triggers the degranulation and secretion process. Disodium cromoglycate (cromolyn DSCG), the disodium salt of 1,3-bis(-2-carboxychromon-5-yloxy)-2-hydroxy...

journal_title：Nature

authors： Mazurek N,Berger G,Pecht I

更新日期：1980-08-14 00:00:00

abstract：:Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoprotein...

journal_title：Nature

authors： Ou WJ,Cameron PH,Thomas DY,Bergeron JJ

更新日期：1993-08-26 00:00:00

abstract：:The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...

journal_title：Nature

authors： Richardson JD,Kasper JC,Wang C,Belcher JW,Lazarus AJ

更新日期：2008-07-03 00:00:00

abstract：:The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...

journal_title：Nature

authors： Pellegrini L,Tan S,Richmond TJ

更新日期：1995-08-10 00:00:00

abstract：:Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...

journal_title：Nature

authors： Dilley RL,Verma P,Cho NW,Winters HD,Wondisford AR,Greenberg RA

更新日期：2016-11-03 00:00:00

abstract：:Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low temperatures typical of shallow crusted faults ...

journal_title：Nature

authors： van der Pluijm BA,Hall CM,Vrolijk PJ,Pevear DR,Covey MC

更新日期：2001-07-12 00:00:00